The Potential Role of Osteopontin and Furin in Worsening Disease Outcomes in COVID-19 Patients with Pre-Existing Diabetes
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the ongoing coronavirus disease 2019 (COVID-19) pandemic, with more than 50 million cases reported globally. Findings have consistently identified an increased severity of SARS-CoV-2 infection in individuals with diabe...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-11-01
|
| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/9/11/2528 |
| _version_ | 1827701650727370752 |
|---|---|
| author | Yvonne Adu-Agyeiwaah Maria B. Grant Alexander G. Obukhov |
| author_facet | Yvonne Adu-Agyeiwaah Maria B. Grant Alexander G. Obukhov |
| author_sort | Yvonne Adu-Agyeiwaah |
| collection | DOAJ |
| description | The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the ongoing coronavirus disease 2019 (COVID-19) pandemic, with more than 50 million cases reported globally. Findings have consistently identified an increased severity of SARS-CoV-2 infection in individuals with diabetes. Osteopontin, a cytokine-like matrix-associated phosphoglycoprotein, is elevated in diabetes and drives the expression of furin, a proprotein convertase implicated in the proteolytic processing and activation of several precursors, including chemokines, growth factors, hormones, adhesion molecules, and receptors. Elevated serum furin is a signature of diabetes mellitus progression and is associated with a dysmetabolic phenotype and increased risk of diabetes-linked premature mortality. Additionally, furin plays an important role in enhancing the infectivity of SARS-CoV-2 by promoting its entry and replication in the host cell. Here, we hypothesize that diabetes-induced osteopontin and furin protein upregulation results in worse outcomes in diabetic patients with SARS-CoV-2 infection owing to the roles of these protein in promoting viral infection and increasing metabolic dysfunction. Thus, targeting the osteopontin-furin axis may be a plausible strategy for reducing mortality in SARS-CoV-2 patients with diabetes. |
| first_indexed | 2024-03-10T14:38:18Z |
| format | Article |
| id | doaj.art-d841b027c8d7410c91e5528d8d24356c |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T14:38:18Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-d841b027c8d7410c91e5528d8d24356c2023-11-20T22:01:15ZengMDPI AGCells2073-44092020-11-01911252810.3390/cells9112528The Potential Role of Osteopontin and Furin in Worsening Disease Outcomes in COVID-19 Patients with Pre-Existing DiabetesYvonne Adu-Agyeiwaah0Maria B. Grant1Alexander G. Obukhov2Department of Ophthalmology and Visual Sciences, School of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USADepartment of Ophthalmology and Visual Sciences, School of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USADepartment of Anatomy, Cell Biology & Physiology, The Indiana University School of Medicine, Indiana University, Indianapolis, IN 46202, USAThe novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the ongoing coronavirus disease 2019 (COVID-19) pandemic, with more than 50 million cases reported globally. Findings have consistently identified an increased severity of SARS-CoV-2 infection in individuals with diabetes. Osteopontin, a cytokine-like matrix-associated phosphoglycoprotein, is elevated in diabetes and drives the expression of furin, a proprotein convertase implicated in the proteolytic processing and activation of several precursors, including chemokines, growth factors, hormones, adhesion molecules, and receptors. Elevated serum furin is a signature of diabetes mellitus progression and is associated with a dysmetabolic phenotype and increased risk of diabetes-linked premature mortality. Additionally, furin plays an important role in enhancing the infectivity of SARS-CoV-2 by promoting its entry and replication in the host cell. Here, we hypothesize that diabetes-induced osteopontin and furin protein upregulation results in worse outcomes in diabetic patients with SARS-CoV-2 infection owing to the roles of these protein in promoting viral infection and increasing metabolic dysfunction. Thus, targeting the osteopontin-furin axis may be a plausible strategy for reducing mortality in SARS-CoV-2 patients with diabetes.https://www.mdpi.com/2073-4409/9/11/2528coronavirusosteopontinfurindiabetesACE2 |
| spellingShingle | Yvonne Adu-Agyeiwaah Maria B. Grant Alexander G. Obukhov The Potential Role of Osteopontin and Furin in Worsening Disease Outcomes in COVID-19 Patients with Pre-Existing Diabetes Cells coronavirus osteopontin furin diabetes ACE2 |
| title | The Potential Role of Osteopontin and Furin in Worsening Disease Outcomes in COVID-19 Patients with Pre-Existing Diabetes |
| title_full | The Potential Role of Osteopontin and Furin in Worsening Disease Outcomes in COVID-19 Patients with Pre-Existing Diabetes |
| title_fullStr | The Potential Role of Osteopontin and Furin in Worsening Disease Outcomes in COVID-19 Patients with Pre-Existing Diabetes |
| title_full_unstemmed | The Potential Role of Osteopontin and Furin in Worsening Disease Outcomes in COVID-19 Patients with Pre-Existing Diabetes |
| title_short | The Potential Role of Osteopontin and Furin in Worsening Disease Outcomes in COVID-19 Patients with Pre-Existing Diabetes |
| title_sort | potential role of osteopontin and furin in worsening disease outcomes in covid 19 patients with pre existing diabetes |
| topic | coronavirus osteopontin furin diabetes ACE2 |
| url | https://www.mdpi.com/2073-4409/9/11/2528 |
| work_keys_str_mv | AT yvonneaduagyeiwaah thepotentialroleofosteopontinandfurininworseningdiseaseoutcomesincovid19patientswithpreexistingdiabetes AT mariabgrant thepotentialroleofosteopontinandfurininworseningdiseaseoutcomesincovid19patientswithpreexistingdiabetes AT alexandergobukhov thepotentialroleofosteopontinandfurininworseningdiseaseoutcomesincovid19patientswithpreexistingdiabetes AT yvonneaduagyeiwaah potentialroleofosteopontinandfurininworseningdiseaseoutcomesincovid19patientswithpreexistingdiabetes AT mariabgrant potentialroleofosteopontinandfurininworseningdiseaseoutcomesincovid19patientswithpreexistingdiabetes AT alexandergobukhov potentialroleofosteopontinandfurininworseningdiseaseoutcomesincovid19patientswithpreexistingdiabetes |