Prepuberal insulin secretory indices are long-term predictors of short adult stature in cystic fibrosis
Objective: Diabetes is a frequent comorbidity in cystic fibrosis (CF), rela ted to multiple unfavorable outcomes. During the progression of β-cell dysfunction to diabetes, insulin deficiency could possibly reduce the anabolic support to grow ev en in the absence of significant glycemic derangements....
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Bioscientifica
2022-05-01
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| Series: | Endocrine Connections |
| Subjects: | |
| Online Access: | https://ec.bioscientifica.com/view/journals/ec/11/5/EC-22-0056.xml |
| _version_ | 1818210773940305920 |
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| author | Alberto Battezzati Andrea Foppiani Gianfranco Alicandro Arianna Bisogno Arianna Biffi Giorgio Bedogni Simona Bertoli Giulia De Carlo Erica Nazzari Carla Colombo |
| author_facet | Alberto Battezzati Andrea Foppiani Gianfranco Alicandro Arianna Bisogno Arianna Biffi Giorgio Bedogni Simona Bertoli Giulia De Carlo Erica Nazzari Carla Colombo |
| author_sort | Alberto Battezzati |
| collection | DOAJ |
| description | Objective: Diabetes is a frequent comorbidity in cystic fibrosis (CF), rela ted to multiple unfavorable outcomes. During the progression of β-cell dysfunction to diabetes, insulin deficiency could possibly reduce the anabolic support to grow ev en in the absence of significant glycemic derangements. To test this hypothesis, w e evaluated whether prepuberal insulin secretory indices are independent predictors of adult height.
Design: Observational cohort study.
Research design and methods: A longitudinal analysis of 66 CF patients (33 females) from an ongoing cohort received at prepuberal age (median age of 12 years) modified 3-h oral glucose tolerance tests with 30-min insulin and C-peptide sampling, modeling of insulin secretory and sensitivity parameters, anthropometric evaluation. The latter was repeated when adults after a median follow-up of 9 years.
Results: In alternative models, we found a positive association with eit her basal insulin secretion (mean 0.22, 95% CI 0.01, 0.44 z-scores) or prepuberal β-cell glucose sensitivity (mean 0.23, 95% CI 0.00, 0.46 z-scores) and adult height, while total insulin secretion was negatively related to adult height (mean −0.36, 95% CI −0.57, −0.15 z-scores or mean −0.42, 95% CI −0.69, −0.16 z-scores, respectively). The high total insulin secretion of low adult height patients was mainly due to late (>60 min) secretio n and was associated with a worse glucose response during OGTT.
Conclusions: Abnormal insulin secretion associated with high glucose respons e during OGTT predicts a decrease in adult height z-score. Our results s uggest that insulin secretory defects in CF affect growth prior to the development of fasting hyperglycemia. |
| first_indexed | 2024-12-12T05:21:56Z |
| format | Article |
| id | doaj.art-d84258a4d2ac45fd875da8286fac12da |
| institution | Directory Open Access Journal |
| issn | 2049-3614 |
| language | English |
| last_indexed | 2024-12-12T05:21:56Z |
| publishDate | 2022-05-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrine Connections |
| spelling | doaj.art-d84258a4d2ac45fd875da8286fac12da2022-12-22T00:36:36ZengBioscientificaEndocrine Connections2049-36142022-05-01115110https://doi.org/10.1530/EC-22-0056Prepuberal insulin secretory indices are long-term predictors of short adult stature in cystic fibrosisAlberto Battezzati0Andrea Foppiani1Gianfranco Alicandro2Arianna Bisogno3Arianna Biffi4Giorgio Bedogni5Simona Bertoli6Giulia De Carlo7Erica Nazzari8Carla Colombo9International Center for the Assessment of Nutritional Status, DeFENS, University of Milan, Milan, ItalyInternational Center for the Assessment of Nutritional Status, DeFENS, University of Milan, Milan, ItalyCystic Fibrosis Center, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca’ Granda, Ospedale Maggiore Policlinico, University of Milan, Milan, ItalyCystic Fibrosis Center, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca’ Granda, Ospedale Maggiore Policlinico, University of Milan, Milan, ItalyCystic Fibrosis Center, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca’ Granda, Ospedale Maggiore Policlinico, University of Milan, Milan, ItalyCystic Fibrosis Center, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca’ Granda, Ospedale Maggiore Policlinico, University of Milan, Milan, ItalyDepartment of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy; Internal Medicine, S. Maria delle Croci Hospital, AUSL Romagna, Ravenna, ItalyInternational Center for the Assessment of Nutritional Status, DeFENS, University of Milan, Milan, ItalyInternational Center for the Assessment of Nutritional Status, DeFENS, University of Milan, Milan, ItalyCystic Fibrosis Center, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca’ Granda, Ospedale Maggiore Policlinico, University of Milan, Milan, ItalyCystic Fibrosis Center, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca’ Granda, Ospedale Maggiore Policlinico, University of Milan, Milan, ItalyObjective: Diabetes is a frequent comorbidity in cystic fibrosis (CF), rela ted to multiple unfavorable outcomes. During the progression of β-cell dysfunction to diabetes, insulin deficiency could possibly reduce the anabolic support to grow ev en in the absence of significant glycemic derangements. To test this hypothesis, w e evaluated whether prepuberal insulin secretory indices are independent predictors of adult height. Design: Observational cohort study. Research design and methods: A longitudinal analysis of 66 CF patients (33 females) from an ongoing cohort received at prepuberal age (median age of 12 years) modified 3-h oral glucose tolerance tests with 30-min insulin and C-peptide sampling, modeling of insulin secretory and sensitivity parameters, anthropometric evaluation. The latter was repeated when adults after a median follow-up of 9 years. Results: In alternative models, we found a positive association with eit her basal insulin secretion (mean 0.22, 95% CI 0.01, 0.44 z-scores) or prepuberal β-cell glucose sensitivity (mean 0.23, 95% CI 0.00, 0.46 z-scores) and adult height, while total insulin secretion was negatively related to adult height (mean −0.36, 95% CI −0.57, −0.15 z-scores or mean −0.42, 95% CI −0.69, −0.16 z-scores, respectively). The high total insulin secretion of low adult height patients was mainly due to late (>60 min) secretio n and was associated with a worse glucose response during OGTT. Conclusions: Abnormal insulin secretion associated with high glucose respons e during OGTT predicts a decrease in adult height z-score. Our results s uggest that insulin secretory defects in CF affect growth prior to the development of fasting hyperglycemia.https://ec.bioscientifica.com/view/journals/ec/11/5/EC-22-0056.xmlcystic fibrosisoral glucose tolerance testinsulin secretionbeta cell glucose sensitivity |
| spellingShingle | Alberto Battezzati Andrea Foppiani Gianfranco Alicandro Arianna Bisogno Arianna Biffi Giorgio Bedogni Simona Bertoli Giulia De Carlo Erica Nazzari Carla Colombo Prepuberal insulin secretory indices are long-term predictors of short adult stature in cystic fibrosis Endocrine Connections cystic fibrosis oral glucose tolerance test insulin secretion beta cell glucose sensitivity |
| title | Prepuberal insulin secretory indices are long-term predictors of short adult stature in cystic fibrosis |
| title_full | Prepuberal insulin secretory indices are long-term predictors of short adult stature in cystic fibrosis |
| title_fullStr | Prepuberal insulin secretory indices are long-term predictors of short adult stature in cystic fibrosis |
| title_full_unstemmed | Prepuberal insulin secretory indices are long-term predictors of short adult stature in cystic fibrosis |
| title_short | Prepuberal insulin secretory indices are long-term predictors of short adult stature in cystic fibrosis |
| title_sort | prepuberal insulin secretory indices are long term predictors of short adult stature in cystic fibrosis |
| topic | cystic fibrosis oral glucose tolerance test insulin secretion beta cell glucose sensitivity |
| url | https://ec.bioscientifica.com/view/journals/ec/11/5/EC-22-0056.xml |
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