Antimicrobial Peptides and Their Assemblies
Antibiotic resistance requires alternatives to fight multi-drug resistant strains. Antimicrobial peptides (AMPs) act by disrupting or solubilizing microbial cell walls or membranes in accordance with mechanisms difficult to counteract from the microbe’s point of view. In this review, structure–activ...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Future Pharmacology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-9879/3/4/47 |
| _version_ | 1797381006176550912 |
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| author | Ana Maria Carmona-Ribeiro |
| author_facet | Ana Maria Carmona-Ribeiro |
| author_sort | Ana Maria Carmona-Ribeiro |
| collection | DOAJ |
| description | Antibiotic resistance requires alternatives to fight multi-drug resistant strains. Antimicrobial peptides (AMPs) act by disrupting or solubilizing microbial cell walls or membranes in accordance with mechanisms difficult to counteract from the microbe’s point of view. In this review, structure–activity relationships for AMPs and their assemblies are discussed, considering not only their self-assembly but also their interactions with their carriers for optimal delivery or their combinations with other complementary antimicrobials or moieties covalently bound to their chemical structure. The effect of the formulations on AMP activity is also evaluated, revealing a myriad of possibilities. Depending on the interaction forces between the AMP, the carrier, or the elements added to the formulations, AMP activity can be reduced, enhanced, or remain unaffected. Approaches protecting AMPs against proteolysis may also reduce their activity. |
| first_indexed | 2024-03-08T20:45:09Z |
| format | Article |
| id | doaj.art-d8425dbe238c4ca99c8b1f080fb85f6a |
| institution | Directory Open Access Journal |
| issn | 2673-9879 |
| language | English |
| last_indexed | 2024-03-08T20:45:09Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Future Pharmacology |
| spelling | doaj.art-d8425dbe238c4ca99c8b1f080fb85f6a2023-12-22T14:10:16ZengMDPI AGFuture Pharmacology2673-98792023-10-013476378810.3390/futurepharmacol3040047Antimicrobial Peptides and Their AssembliesAna Maria Carmona-Ribeiro0Biocolloids Laboratory, Biochemistry Department, Chemistry Institute, São Paulo State University, Avenida Professor Lineu Prestes, 748, Butantan, São Paulo 05508-000, BrazilAntibiotic resistance requires alternatives to fight multi-drug resistant strains. Antimicrobial peptides (AMPs) act by disrupting or solubilizing microbial cell walls or membranes in accordance with mechanisms difficult to counteract from the microbe’s point of view. In this review, structure–activity relationships for AMPs and their assemblies are discussed, considering not only their self-assembly but also their interactions with their carriers for optimal delivery or their combinations with other complementary antimicrobials or moieties covalently bound to their chemical structure. The effect of the formulations on AMP activity is also evaluated, revealing a myriad of possibilities. Depending on the interaction forces between the AMP, the carrier, or the elements added to the formulations, AMP activity can be reduced, enhanced, or remain unaffected. Approaches protecting AMPs against proteolysis may also reduce their activity.https://www.mdpi.com/2673-9879/3/4/47AMPs approved in the clinicAMP degradation and toxicitymechanisms of actionAMP self-assembliesAMPs combined with other antimicrobialsAMP delivery |
| spellingShingle | Ana Maria Carmona-Ribeiro Antimicrobial Peptides and Their Assemblies Future Pharmacology AMPs approved in the clinic AMP degradation and toxicity mechanisms of action AMP self-assemblies AMPs combined with other antimicrobials AMP delivery |
| title | Antimicrobial Peptides and Their Assemblies |
| title_full | Antimicrobial Peptides and Their Assemblies |
| title_fullStr | Antimicrobial Peptides and Their Assemblies |
| title_full_unstemmed | Antimicrobial Peptides and Their Assemblies |
| title_short | Antimicrobial Peptides and Their Assemblies |
| title_sort | antimicrobial peptides and their assemblies |
| topic | AMPs approved in the clinic AMP degradation and toxicity mechanisms of action AMP self-assemblies AMPs combined with other antimicrobials AMP delivery |
| url | https://www.mdpi.com/2673-9879/3/4/47 |
| work_keys_str_mv | AT anamariacarmonaribeiro antimicrobialpeptidesandtheirassemblies |