Interaction between mitochondrial NADH dehydrogenase subunit-2 5178 C > A and clinical risk factors on the susceptibility of essential hypertension in Chinese population
Abstract Background The mitochondrial genotype 5178 cytosine/adenine (5178 C > A) within the NADH dehydrogenase subunit-2 gene (ND2) was proved to associate with longevity and predispose resistance to adult-onset diseases. This study aimed to confirm the interactive effects between ND 25178 C >...
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| Format: | Article |
| Language: | English |
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BMC
2019-07-01
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| Series: | BMC Medical Genetics |
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| Online Access: | http://link.springer.com/article/10.1186/s12881-019-0838-3 |
| _version_ | 1818741539222847488 |
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| author | Xi Chen Xiang-Yu He Chao Zhu Yusong Zhang Zongbin Li Yuqi Liu Yuxiao Zhang Tong Yin Yang Li |
| author_facet | Xi Chen Xiang-Yu He Chao Zhu Yusong Zhang Zongbin Li Yuqi Liu Yuxiao Zhang Tong Yin Yang Li |
| author_sort | Xi Chen |
| collection | DOAJ |
| description | Abstract Background The mitochondrial genotype 5178 cytosine/adenine (5178 C > A) within the NADH dehydrogenase subunit-2 gene (ND2) was proved to associate with longevity and predispose resistance to adult-onset diseases. This study aimed to confirm the interactive effects between ND 25178 C > A and clinical risk factors on the susceptibility of essential hypertension in Chinese general population. Materials and Methods The relationship between the ND2 5178 C > A variation and the risk of hypertension was investigated in 817 hypertensives and 821 matched normotensives. The interactive effects between ND2 5178 C > A and clinical risk factors were evaluated. Results The ND2 5178 A allele was more frequent in normotensives than in hypertensives (32.64% vs. 24.24%; adjusted OR: 0.62, 95% CI: 0.49–0.79, P = 1.3 × 10− 4). After stratification, the significant association between ND2 5178 C > A and hypertension was found only in current smokers (OR: 0.44, 95% CI: 0.31–0.62), but not in non-current smokers (p < 0.01 for interaction). Smoking status (OR: 1.51, 95% CI: 1.11–2.06) and high triglycerides (OR: 1.57, 95% CI: 1.10–2.24) were found independently associated with hypertension only in carriers of 5178 C allele but not in carriers of 5178 A allele. Conclusions In conclusion, ND2 5178 A allele could confer a lower risk for essential hypertension in Chinese by the interaction with smoking status. The higher risk of hypertension imposed by smoking and high TG may be altered by ND2 5178 A allele. |
| first_indexed | 2024-12-18T01:58:14Z |
| format | Article |
| id | doaj.art-d842d3bad0424bcfa81d58d50af6a3d2 |
| institution | Directory Open Access Journal |
| issn | 1471-2350 |
| language | English |
| last_indexed | 2024-12-18T01:58:14Z |
| publishDate | 2019-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medical Genetics |
| spelling | doaj.art-d842d3bad0424bcfa81d58d50af6a3d22022-12-21T21:24:52ZengBMCBMC Medical Genetics1471-23502019-07-012011710.1186/s12881-019-0838-3Interaction between mitochondrial NADH dehydrogenase subunit-2 5178 C > A and clinical risk factors on the susceptibility of essential hypertension in Chinese populationXi Chen0Xiang-Yu He1Chao Zhu2Yusong Zhang3Zongbin Li4Yuqi Liu5Yuxiao Zhang6Tong Yin7Yang Li8Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Ophthalmology, 958 Hospital of PLA ARMYDepartment of Cardiology, Beijing Friendship Hospital, Capital Medical UniversityDepartment of Cardiology, General Hospital of Chinese People’s Liberation ArmyDepartment of Cardiology, General Hospital of Chinese People’s Liberation ArmyDepartment of Cardiology, General Hospital of Chinese People’s Liberation ArmyDepartment of Cardiology, General Hospital of Chinese People’s Liberation ArmyDepartment of Cardiology, General Hospital of Chinese People’s Liberation ArmyDepartment of Cardiology, General Hospital of Chinese People’s Liberation ArmyAbstract Background The mitochondrial genotype 5178 cytosine/adenine (5178 C > A) within the NADH dehydrogenase subunit-2 gene (ND2) was proved to associate with longevity and predispose resistance to adult-onset diseases. This study aimed to confirm the interactive effects between ND 25178 C > A and clinical risk factors on the susceptibility of essential hypertension in Chinese general population. Materials and Methods The relationship between the ND2 5178 C > A variation and the risk of hypertension was investigated in 817 hypertensives and 821 matched normotensives. The interactive effects between ND2 5178 C > A and clinical risk factors were evaluated. Results The ND2 5178 A allele was more frequent in normotensives than in hypertensives (32.64% vs. 24.24%; adjusted OR: 0.62, 95% CI: 0.49–0.79, P = 1.3 × 10− 4). After stratification, the significant association between ND2 5178 C > A and hypertension was found only in current smokers (OR: 0.44, 95% CI: 0.31–0.62), but not in non-current smokers (p < 0.01 for interaction). Smoking status (OR: 1.51, 95% CI: 1.11–2.06) and high triglycerides (OR: 1.57, 95% CI: 1.10–2.24) were found independently associated with hypertension only in carriers of 5178 C allele but not in carriers of 5178 A allele. Conclusions In conclusion, ND2 5178 A allele could confer a lower risk for essential hypertension in Chinese by the interaction with smoking status. The higher risk of hypertension imposed by smoking and high TG may be altered by ND2 5178 A allele.http://link.springer.com/article/10.1186/s12881-019-0838-3HypertensionMitochondriaNADH dehydrogenase subunit 2VariationInteraction |
| spellingShingle | Xi Chen Xiang-Yu He Chao Zhu Yusong Zhang Zongbin Li Yuqi Liu Yuxiao Zhang Tong Yin Yang Li Interaction between mitochondrial NADH dehydrogenase subunit-2 5178 C > A and clinical risk factors on the susceptibility of essential hypertension in Chinese population BMC Medical Genetics Hypertension Mitochondria NADH dehydrogenase subunit 2 Variation Interaction |
| title | Interaction between mitochondrial NADH dehydrogenase subunit-2 5178 C > A and clinical risk factors on the susceptibility of essential hypertension in Chinese population |
| title_full | Interaction between mitochondrial NADH dehydrogenase subunit-2 5178 C > A and clinical risk factors on the susceptibility of essential hypertension in Chinese population |
| title_fullStr | Interaction between mitochondrial NADH dehydrogenase subunit-2 5178 C > A and clinical risk factors on the susceptibility of essential hypertension in Chinese population |
| title_full_unstemmed | Interaction between mitochondrial NADH dehydrogenase subunit-2 5178 C > A and clinical risk factors on the susceptibility of essential hypertension in Chinese population |
| title_short | Interaction between mitochondrial NADH dehydrogenase subunit-2 5178 C > A and clinical risk factors on the susceptibility of essential hypertension in Chinese population |
| title_sort | interaction between mitochondrial nadh dehydrogenase subunit 2 5178 c a and clinical risk factors on the susceptibility of essential hypertension in chinese population |
| topic | Hypertension Mitochondria NADH dehydrogenase subunit 2 Variation Interaction |
| url | http://link.springer.com/article/10.1186/s12881-019-0838-3 |
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