Supramolecular co-assembled hybrid hydrogels for antibacterial therapy
Bacterial infections arising from antibiotic-resistant strains represent a formidable global health threat. In the realm of antibacterial therapies, supramolecular hydrogels stand out with unique advantages owing to their adaptable and flexible non-covalent interactions with diverse biomolecules. Th...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2024-12-01
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| Series: | Supramolecular Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667240524000023 |
| _version_ | 1797351521386496000 |
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| author | Zakia Riaz Sravan Baddi Chuan-Liang Feng |
| author_facet | Zakia Riaz Sravan Baddi Chuan-Liang Feng |
| author_sort | Zakia Riaz |
| collection | DOAJ |
| description | Bacterial infections arising from antibiotic-resistant strains represent a formidable global health threat. In the realm of antibacterial therapies, supramolecular hydrogels stand out with unique advantages owing to their adaptable and flexible non-covalent interactions with diverse biomolecules. Their ability to encapsulate a variety of biologically active agents through co-assembly further amplifies their efficacy, endowing these hybrid hydrogels with a spectrum of functionalities within a unified system. Various functionalities encompass self-healing, injectability, tissue adhesion, facile drug loading, controlled release mechanisms, biocompatibility, antibacterial properties, and antioxidative attributes. This review article delves into two categories of supramolecular antibacterial hydrogels: i) those with intrinsic antibacterial attributes and ii) supramolecular co-assembled hybrid hydrogels formed through the integration of hydrogels with an assortment of active antibacterial agents, including various nanomaterials, antibiotics, biologically active compounds derived from natural sources, and antibacterial polymers. The anticipated role of supramolecular co-assembled hybrid hydrogels, coupled with contemporary medical technologies and devices, is paramount in the development of highly effective and secure platforms for antibacterial therapy. Furthermore, review addresses the current challenges in the realm of antibacterial hydrogels while elucidating prospective future advancements in this field. |
| first_indexed | 2024-03-08T13:01:41Z |
| format | Article |
| id | doaj.art-d84468e0322b48e08673012f5c276aba |
| institution | Directory Open Access Journal |
| issn | 2667-2405 |
| language | English |
| last_indexed | 2024-03-08T13:01:41Z |
| publishDate | 2024-12-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Supramolecular Materials |
| spelling | doaj.art-d84468e0322b48e08673012f5c276aba2024-01-19T05:03:34ZengKeAi Communications Co., Ltd.Supramolecular Materials2667-24052024-12-013100064Supramolecular co-assembled hybrid hydrogels for antibacterial therapyZakia Riaz0Sravan Baddi1Chuan-Liang Feng2State Key Lab of Metal Matrix Composites, Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Materials Science and Engineering, Shanghai Jiaotong University, Dongchuan Rd 800, 200240 Shanghai, ChinaCorresponding authors.; State Key Lab of Metal Matrix Composites, Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Materials Science and Engineering, Shanghai Jiaotong University, Dongchuan Rd 800, 200240 Shanghai, ChinaCorresponding authors.; State Key Lab of Metal Matrix Composites, Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Materials Science and Engineering, Shanghai Jiaotong University, Dongchuan Rd 800, 200240 Shanghai, ChinaBacterial infections arising from antibiotic-resistant strains represent a formidable global health threat. In the realm of antibacterial therapies, supramolecular hydrogels stand out with unique advantages owing to their adaptable and flexible non-covalent interactions with diverse biomolecules. Their ability to encapsulate a variety of biologically active agents through co-assembly further amplifies their efficacy, endowing these hybrid hydrogels with a spectrum of functionalities within a unified system. Various functionalities encompass self-healing, injectability, tissue adhesion, facile drug loading, controlled release mechanisms, biocompatibility, antibacterial properties, and antioxidative attributes. This review article delves into two categories of supramolecular antibacterial hydrogels: i) those with intrinsic antibacterial attributes and ii) supramolecular co-assembled hybrid hydrogels formed through the integration of hydrogels with an assortment of active antibacterial agents, including various nanomaterials, antibiotics, biologically active compounds derived from natural sources, and antibacterial polymers. The anticipated role of supramolecular co-assembled hybrid hydrogels, coupled with contemporary medical technologies and devices, is paramount in the development of highly effective and secure platforms for antibacterial therapy. Furthermore, review addresses the current challenges in the realm of antibacterial hydrogels while elucidating prospective future advancements in this field.http://www.sciencedirect.com/science/article/pii/S2667240524000023Supramolecular hybrid hydrogelAntibacterial agentsCo-assemblyNon-covalent interactionBiomedical applications |
| spellingShingle | Zakia Riaz Sravan Baddi Chuan-Liang Feng Supramolecular co-assembled hybrid hydrogels for antibacterial therapy Supramolecular Materials Supramolecular hybrid hydrogel Antibacterial agents Co-assembly Non-covalent interaction Biomedical applications |
| title | Supramolecular co-assembled hybrid hydrogels for antibacterial therapy |
| title_full | Supramolecular co-assembled hybrid hydrogels for antibacterial therapy |
| title_fullStr | Supramolecular co-assembled hybrid hydrogels for antibacterial therapy |
| title_full_unstemmed | Supramolecular co-assembled hybrid hydrogels for antibacterial therapy |
| title_short | Supramolecular co-assembled hybrid hydrogels for antibacterial therapy |
| title_sort | supramolecular co assembled hybrid hydrogels for antibacterial therapy |
| topic | Supramolecular hybrid hydrogel Antibacterial agents Co-assembly Non-covalent interaction Biomedical applications |
| url | http://www.sciencedirect.com/science/article/pii/S2667240524000023 |
| work_keys_str_mv | AT zakiariaz supramolecularcoassembledhybridhydrogelsforantibacterialtherapy AT sravanbaddi supramolecularcoassembledhybridhydrogelsforantibacterialtherapy AT chuanliangfeng supramolecularcoassembledhybridhydrogelsforantibacterialtherapy |