Association between Maternal Serum 25-Hydroxyvitamin D Concentrations and the Risk of Preterm Birth in Central Sudan: A Case–Control Study
There are few published studies on the association between vitamin D concentrations and preterm birth (PB) in sub-Saharan Africa. The current study aimed to assess the association between 25-hydroxyvitamin D (25[OH)] D) levels and PB. A matched case–control study (60 women in each arm) was conducted...
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MDPI AG
2022-02-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/4/891 |
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| author | Somia K. Abdelrahiem Manal E. Sharif Nadiah ALhabardi Osama Al-Wutayd Ishag Adam |
| author_facet | Somia K. Abdelrahiem Manal E. Sharif Nadiah ALhabardi Osama Al-Wutayd Ishag Adam |
| author_sort | Somia K. Abdelrahiem |
| collection | DOAJ |
| description | There are few published studies on the association between vitamin D concentrations and preterm birth (PB) in sub-Saharan Africa. The current study aimed to assess the association between 25-hydroxyvitamin D (25[OH)] D) levels and PB. A matched case–control study (60 women in each arm) was conducted in Medani maternity hospital in central Sudan. The cases were women with spontaneous PB, and healthy women with term deliveries were the controls. The clinical/medical and obstetric history was gathered using a questionnaire. The enzyme-linked immunosorbent assay was used to measure the serum 25(OH)D levels. Women with PB had significantly lower median (interquartile range) 25(OH)D concentrations compared with the controls (18.4 (7.3) ng/mL vs. 20.2 (16.5) ng/mL, <i>p</i> = 0.001). Forty-two (70.0%) women with PB and 29 (48.3%) women in the control group had vitamin D deficiency (25(OH)D level ≤ 20 ng/mL). The results of the multivariable logistic regression showed that the 25(OH)D concentrations were negatively associated with PB (adjusted odds ratio (aOR) = 0.92, 95% confidence interval (CI) = 0.87–0.97). Vitamin D-deficient pregnant women were at a higher risk of PB (aOR = 2.69, 95% CI = 1.17–6.23). Low 25(OH)D concentrations were found at the time the variable was determined in women with spontaneous PB and were an independent risk factor for PB. |
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| issn | 2072-6643 |
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| last_indexed | 2024-03-09T21:18:16Z |
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| series | Nutrients |
| spelling | doaj.art-d844f9e78e5e47029bb55204ed8791892023-11-23T21:30:00ZengMDPI AGNutrients2072-66432022-02-0114489110.3390/nu14040891Association between Maternal Serum 25-Hydroxyvitamin D Concentrations and the Risk of Preterm Birth in Central Sudan: A Case–Control StudySomia K. Abdelrahiem0Manal E. Sharif1Nadiah ALhabardi2Osama Al-Wutayd3Ishag Adam4Department of Obstetrics and Gynecology, University of Gezira, Sudan. P.O. Box 20, Wad Medani 21111, SudanCollege of Medicine, King Khalid University, Abha 61421, Saudi ArabiaDepartment of Obstetrics and Gynecology, Unaizah College of Medicine and Medical Sciences, Qassim University, Unaizah 56219, Saudi ArabiaDepartment of Family and Community Medicine, Unaizah College of Medicine and Medical Sciences, Qassim University, Unaizah 56219, Saudi ArabiaDepartment of Obstetrics and Gynecology, Unaizah College of Medicine and Medical Sciences, Qassim University, Unaizah 56219, Saudi ArabiaThere are few published studies on the association between vitamin D concentrations and preterm birth (PB) in sub-Saharan Africa. The current study aimed to assess the association between 25-hydroxyvitamin D (25[OH)] D) levels and PB. A matched case–control study (60 women in each arm) was conducted in Medani maternity hospital in central Sudan. The cases were women with spontaneous PB, and healthy women with term deliveries were the controls. The clinical/medical and obstetric history was gathered using a questionnaire. The enzyme-linked immunosorbent assay was used to measure the serum 25(OH)D levels. Women with PB had significantly lower median (interquartile range) 25(OH)D concentrations compared with the controls (18.4 (7.3) ng/mL vs. 20.2 (16.5) ng/mL, <i>p</i> = 0.001). Forty-two (70.0%) women with PB and 29 (48.3%) women in the control group had vitamin D deficiency (25(OH)D level ≤ 20 ng/mL). The results of the multivariable logistic regression showed that the 25(OH)D concentrations were negatively associated with PB (adjusted odds ratio (aOR) = 0.92, 95% confidence interval (CI) = 0.87–0.97). Vitamin D-deficient pregnant women were at a higher risk of PB (aOR = 2.69, 95% CI = 1.17–6.23). Low 25(OH)D concentrations were found at the time the variable was determined in women with spontaneous PB and were an independent risk factor for PB.https://www.mdpi.com/2072-6643/14/4/891preterm birthpregnancyvitamin25(OH)DSudan |
| spellingShingle | Somia K. Abdelrahiem Manal E. Sharif Nadiah ALhabardi Osama Al-Wutayd Ishag Adam Association between Maternal Serum 25-Hydroxyvitamin D Concentrations and the Risk of Preterm Birth in Central Sudan: A Case–Control Study Nutrients preterm birth pregnancy vitamin 25(OH)D Sudan |
| title | Association between Maternal Serum 25-Hydroxyvitamin D Concentrations and the Risk of Preterm Birth in Central Sudan: A Case–Control Study |
| title_full | Association between Maternal Serum 25-Hydroxyvitamin D Concentrations and the Risk of Preterm Birth in Central Sudan: A Case–Control Study |
| title_fullStr | Association between Maternal Serum 25-Hydroxyvitamin D Concentrations and the Risk of Preterm Birth in Central Sudan: A Case–Control Study |
| title_full_unstemmed | Association between Maternal Serum 25-Hydroxyvitamin D Concentrations and the Risk of Preterm Birth in Central Sudan: A Case–Control Study |
| title_short | Association between Maternal Serum 25-Hydroxyvitamin D Concentrations and the Risk of Preterm Birth in Central Sudan: A Case–Control Study |
| title_sort | association between maternal serum 25 hydroxyvitamin d concentrations and the risk of preterm birth in central sudan a case control study |
| topic | preterm birth pregnancy vitamin 25(OH)D Sudan |
| url | https://www.mdpi.com/2072-6643/14/4/891 |
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