GPR65 sensing tumor-derived lactate induces HMGB1 release from TAM via the cAMP/PKA/CREB pathway to promote glioma progression

GPR65 sensing tumor-derived lactate induces HMGB1 release from TAM via the cAMP/PKA/CREB pathway to promote glioma progression

Abstract Background Lactate has emerged as a critical regulator within the tumor microenvironment, including glioma. However, the precise mechanisms underlying how lactate influences the communication between tumor cells and tumor-associated macrophages (TAMs), the most abundant immune cells in glio...

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Bibliographic Details
Main Authors: Chaolong Yan, Zijiang Yang, Pin Chen, Yuyang Yeh, Chongjing Sun, Tao Xie, Wei Huang, Xiaobiao Zhang
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Glioma
Lactate
Tumor-associated macrophage (TAM)
GPR65
HMGB1
Online Access:https://doi.org/10.1186/s13046-024-03025-8

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