Identifying gene variants underlying the pathogenesis of diabetic retinopathy based on integrated genomic and transcriptomic analysis of clinical extreme phenotypes

Identifying gene variants underlying the pathogenesis of diabetic retinopathy based on integrated genomic and transcriptomic analysis of clinical extreme phenotypes

Diabetic retinopathy (DR) is a common complication and the leading cause of blindness in patients with type 2 diabetes. DR has been shown to be closely correlated with blood glucose levels and the duration of diabetes. However, the onset and progression of DR also display clinical heterogeneity. We...

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Bibliographic Details
Main Authors: Qiaoling Song, Yuchao Zhang, Minghui Zhang, Xiaoli Ma, Qianyue Zhang, Chenyang Zhao, Zhongwen Zhang, Huichen Zhao, Wenchao Hu, Xinxin Zhang, Xiwen Ren, Ming An, Jinbo Yang, Yuantao Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Genetics
Subjects:
diabetic retinopathy
exome sequencing
rare variants
pathogenic mutation
RNA-seq analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.929049/full

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https://www.frontiersin.org/articles/10.3389/fgene.2022.929049/full

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