Early effects of insulin therapy on cholesterol synthesis and absorption markers in patients with type 2 diabetes
Summary: Background & aim: Metabolic abnormalities in type 2 diabetes affect the production and the clearance of plasma lipoproteins. Although the improvement of low-density lipoprotein cholesterol, triglyceride, and high-density lipoprotein cholesterol levels are important targets in diabe...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-04-01
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| Series: | Clinical Nutrition Open Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667268523000062 |
| _version_ | 1797846385325768704 |
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| author | Yuji Yamaguchi Kyoko Tanimura-Inagaki Izumi Fukuda Hitoshi Sugihara Shinichi Oikawa |
| author_facet | Yuji Yamaguchi Kyoko Tanimura-Inagaki Izumi Fukuda Hitoshi Sugihara Shinichi Oikawa |
| author_sort | Yuji Yamaguchi |
| collection | DOAJ |
| description | Summary: Background & aim: Metabolic abnormalities in type 2 diabetes affect the production and the clearance of plasma lipoproteins. Although the improvement of low-density lipoprotein cholesterol, triglyceride, and high-density lipoprotein cholesterol levels are important targets in diabetes, it is not established how changes occur in the production and clearance of plasma lipoproteins in the treatment of diabetes. Serum non-cholesterol sterols are introduced as practical markers to assess endogenous cholesterol synthesis and intestinal cholesterol absorption. This study aimed to investigate the effects of insulin therapy on cholesterol synthesis and absorption markers in patients with type 2 diabetes. Methods: This was a single-center, prospective, 2-week, longitudinal pilot study. Patients with type 2 diabetes who were admitted to start insulin therapy without using lipid-lowering agents were recruited. On the day of hospitalization, the patients discontinued all oral hypoglycemic agents and started with basal-bolus insulin therapy. Cholesterol synthesis (lathosterol) and absorption (campesterol, sitosterol, and cholestanol) markers were assessed at baseline and after 2 weeks of insulin treatment. Results: In eighteen subjects, the mean age of the patients was 56 ± 10 years (mean ± SD). At baseline, body mass index was 24.3 ± 5.0 kg/m2, and HbA1c was 11.6 ± 1.7%. After 2 weeks of insulin therapy, total cholesterol (from 205 ± 48 to 184 ± 43 mg/dL, p = 0.004), lathosterol (from 2.6 ± 1.3 to 2.0 ± 0.7 μg/mL, p = 0.001), campesterol (from 4.3 ± 2.7 to 3.0 ± 2.1 μg/mL, p < 0.0001), and sitosterol (from 2.4 ± 1.6 to 1.7 ± 1.4 μg/mL, p < 0.0001) were significantly decreased, and cholestanol (from 2.5 ± 1.0 to 2.3 ± 0.8 μg/mL, p = 0.05) tended to decrease. Conclusion: This study showed that insulin therapy reduces cholesterol synthesis and absorption markers in patients with type 2 diabetes hospitalized within 2 weeks. The decrease in cholesterol synthesis and absorption seems to be useful for improving lipid metabolism and reducing the risk of atherosclerosis. Further randomized controlled studies are required to confirm the efficacy of insulin therapy for cholesterol synthesis and absorption markers. |
| first_indexed | 2024-04-09T17:54:06Z |
| format | Article |
| id | doaj.art-d8486f26d0184feb9194f1e161329775 |
| institution | Directory Open Access Journal |
| issn | 2667-2685 |
| language | English |
| last_indexed | 2024-04-09T17:54:06Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical Nutrition Open Science |
| spelling | doaj.art-d8486f26d0184feb9194f1e1613297752023-04-15T05:55:39ZengElsevierClinical Nutrition Open Science2667-26852023-04-01486474Early effects of insulin therapy on cholesterol synthesis and absorption markers in patients with type 2 diabetesYuji Yamaguchi0Kyoko Tanimura-Inagaki1Izumi Fukuda2Hitoshi Sugihara3Shinichi Oikawa4Department of Endocrinology, Metabolism and Nephrology, Graduate School of Medicine, Nippon Medical School, Tokyo, JapanDepartment of Endocrinology, Metabolism and Nephrology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan; Corresponding author. Department of Endocrinology, Metabolism and Nephrology, Graduate School of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan. Fax: +81 3 5814 6864.Department of Endocrinology, Metabolism and Nephrology, Graduate School of Medicine, Nippon Medical School, Tokyo, JapanDepartment of Endocrinology, Metabolism and Nephrology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan; IVY Clinic, Ibaraki, JapanDepartment of Endocrinology, Metabolism and Nephrology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan; Diabetes and Lifestyle Disease Center, Fukujuji Hospital, Tokyo JapanSummary: Background & aim: Metabolic abnormalities in type 2 diabetes affect the production and the clearance of plasma lipoproteins. Although the improvement of low-density lipoprotein cholesterol, triglyceride, and high-density lipoprotein cholesterol levels are important targets in diabetes, it is not established how changes occur in the production and clearance of plasma lipoproteins in the treatment of diabetes. Serum non-cholesterol sterols are introduced as practical markers to assess endogenous cholesterol synthesis and intestinal cholesterol absorption. This study aimed to investigate the effects of insulin therapy on cholesterol synthesis and absorption markers in patients with type 2 diabetes. Methods: This was a single-center, prospective, 2-week, longitudinal pilot study. Patients with type 2 diabetes who were admitted to start insulin therapy without using lipid-lowering agents were recruited. On the day of hospitalization, the patients discontinued all oral hypoglycemic agents and started with basal-bolus insulin therapy. Cholesterol synthesis (lathosterol) and absorption (campesterol, sitosterol, and cholestanol) markers were assessed at baseline and after 2 weeks of insulin treatment. Results: In eighteen subjects, the mean age of the patients was 56 ± 10 years (mean ± SD). At baseline, body mass index was 24.3 ± 5.0 kg/m2, and HbA1c was 11.6 ± 1.7%. After 2 weeks of insulin therapy, total cholesterol (from 205 ± 48 to 184 ± 43 mg/dL, p = 0.004), lathosterol (from 2.6 ± 1.3 to 2.0 ± 0.7 μg/mL, p = 0.001), campesterol (from 4.3 ± 2.7 to 3.0 ± 2.1 μg/mL, p < 0.0001), and sitosterol (from 2.4 ± 1.6 to 1.7 ± 1.4 μg/mL, p < 0.0001) were significantly decreased, and cholestanol (from 2.5 ± 1.0 to 2.3 ± 0.8 μg/mL, p = 0.05) tended to decrease. Conclusion: This study showed that insulin therapy reduces cholesterol synthesis and absorption markers in patients with type 2 diabetes hospitalized within 2 weeks. The decrease in cholesterol synthesis and absorption seems to be useful for improving lipid metabolism and reducing the risk of atherosclerosis. Further randomized controlled studies are required to confirm the efficacy of insulin therapy for cholesterol synthesis and absorption markers.http://www.sciencedirect.com/science/article/pii/S2667268523000062Basal-bolus insulin therapyCholesterol synthesis markersCholesterol absorption markersType 2 diabetesPoor glycemic control |
| spellingShingle | Yuji Yamaguchi Kyoko Tanimura-Inagaki Izumi Fukuda Hitoshi Sugihara Shinichi Oikawa Early effects of insulin therapy on cholesterol synthesis and absorption markers in patients with type 2 diabetes Clinical Nutrition Open Science Basal-bolus insulin therapy Cholesterol synthesis markers Cholesterol absorption markers Type 2 diabetes Poor glycemic control |
| title | Early effects of insulin therapy on cholesterol synthesis and absorption markers in patients with type 2 diabetes |
| title_full | Early effects of insulin therapy on cholesterol synthesis and absorption markers in patients with type 2 diabetes |
| title_fullStr | Early effects of insulin therapy on cholesterol synthesis and absorption markers in patients with type 2 diabetes |
| title_full_unstemmed | Early effects of insulin therapy on cholesterol synthesis and absorption markers in patients with type 2 diabetes |
| title_short | Early effects of insulin therapy on cholesterol synthesis and absorption markers in patients with type 2 diabetes |
| title_sort | early effects of insulin therapy on cholesterol synthesis and absorption markers in patients with type 2 diabetes |
| topic | Basal-bolus insulin therapy Cholesterol synthesis markers Cholesterol absorption markers Type 2 diabetes Poor glycemic control |
| url | http://www.sciencedirect.com/science/article/pii/S2667268523000062 |
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