Mitochondria as a target in cancer treatment
Abstract Mitochondria are biosynthetic, bioenergetic, and signaling organelles existing in almost all eukaryotic cells, and their dysregulated function has been proved to be essential for tumorigenesis, tumor development, and tumor metastasis. In this short review, first, we briefly summarize the hi...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-09-01
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| Series: | MedComm |
| Online Access: | https://doi.org/10.1002/mco2.16 |
| _version_ | 1818496337939791872 |
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| author | Yu'e Liu Yufeng Shi |
| author_facet | Yu'e Liu Yufeng Shi |
| author_sort | Yu'e Liu |
| collection | DOAJ |
| description | Abstract Mitochondria are biosynthetic, bioenergetic, and signaling organelles existing in almost all eukaryotic cells, and their dysregulated function has been proved to be essential for tumorigenesis, tumor development, and tumor metastasis. In this short review, first, we briefly summarize the historic misunderstanding of mitochondria in tumors, and then come up with a current view that mitochondria play a pivotal role in tumor cells; second, we review how tumor cells rewind mitochondrial function for their oncogenic purpose via known or unknown mechanisms by key oncogenes or tumor suppressors; third, we go through reagents and strategies currently available targeting mitochondria when treating tumors. Recently, merging data suggest that slow cycling cancer cells/cancer stem cells have distinctive mitochondrial metabolism comparing to bulk tumor cells and mitochondria inhibitors seem to be promising to target them, which are resistant to traditional radio and chemotherapies. We thus discuss role of mitochondria in these cancer stem cells and summarize mitochondria as a target from different aspects. |
| first_indexed | 2024-12-10T18:31:59Z |
| format | Article |
| id | doaj.art-d8518dd6131e4f4683c94273a179fe01 |
| institution | Directory Open Access Journal |
| issn | 2688-2663 |
| language | English |
| last_indexed | 2024-12-10T18:31:59Z |
| publishDate | 2020-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | MedComm |
| spelling | doaj.art-d8518dd6131e4f4683c94273a179fe012022-12-22T01:37:55ZengWileyMedComm2688-26632020-09-011212913910.1002/mco2.16Mitochondria as a target in cancer treatmentYu'e Liu0Yufeng Shi1Tongji University Cancer Center Shanghai Tenth People's Hospital of Tongji University School of Medicine Tongji University Shanghai ChinaTongji University Cancer Center Shanghai Tenth People's Hospital of Tongji University School of Medicine Tongji University Shanghai ChinaAbstract Mitochondria are biosynthetic, bioenergetic, and signaling organelles existing in almost all eukaryotic cells, and their dysregulated function has been proved to be essential for tumorigenesis, tumor development, and tumor metastasis. In this short review, first, we briefly summarize the historic misunderstanding of mitochondria in tumors, and then come up with a current view that mitochondria play a pivotal role in tumor cells; second, we review how tumor cells rewind mitochondrial function for their oncogenic purpose via known or unknown mechanisms by key oncogenes or tumor suppressors; third, we go through reagents and strategies currently available targeting mitochondria when treating tumors. Recently, merging data suggest that slow cycling cancer cells/cancer stem cells have distinctive mitochondrial metabolism comparing to bulk tumor cells and mitochondria inhibitors seem to be promising to target them, which are resistant to traditional radio and chemotherapies. We thus discuss role of mitochondria in these cancer stem cells and summarize mitochondria as a target from different aspects.https://doi.org/10.1002/mco2.16 |
| spellingShingle | Yu'e Liu Yufeng Shi Mitochondria as a target in cancer treatment MedComm |
| title | Mitochondria as a target in cancer treatment |
| title_full | Mitochondria as a target in cancer treatment |
| title_fullStr | Mitochondria as a target in cancer treatment |
| title_full_unstemmed | Mitochondria as a target in cancer treatment |
| title_short | Mitochondria as a target in cancer treatment |
| title_sort | mitochondria as a target in cancer treatment |
| url | https://doi.org/10.1002/mco2.16 |
| work_keys_str_mv | AT yueliu mitochondriaasatargetincancertreatment AT yufengshi mitochondriaasatargetincancertreatment |