Inferring host gene subnetworks involved in viral replication.
Systematic, genome-wide loss-of-function experiments can be used to identify host factors that directly or indirectly facilitate or inhibit the replication of a virus in a host cell. We present an approach that combines an integer linear program and a diffusion kernel method to infer the pathways th...
Main Authors: | Deborah Chasman, Brandi Gancarz, Linhui Hao, Michael Ferris, Paul Ahlquist, Mark Craven |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-05-01
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Series: | PLoS Computational Biology |
Online Access: | http://europepmc.org/articles/PMC4038467?pdf=render |
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