Investigation of In Vitro Cytocompatibility of Zinc-Containing Coatings Developed on Medical Magnesium Alloys
In a neutral solution, we investigated the effects of Na<sub>2</sub>[ZnEDTA] concentrations at 0, 6, 12, 18, and 24 g/L on surface morphology, chemical composition, degradation resistance, and in vitro cytocompatibility of micro-arc oxidation (MAO) coatings developed on WE43 (Mg-Y-Nd-Zr)...
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MDPI AG
2023-12-01
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| Online Access: | https://www.mdpi.com/1996-1944/17/1/209 |
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| author | Yun Wang Yuzhi Liu Yuanyuan Zhu Fanglei Yu Rongfang Zhao Xinying Lai Haijun Jiang Tianhong Xu Ying Zhao Rongfa Zhang |
| author_facet | Yun Wang Yuzhi Liu Yuanyuan Zhu Fanglei Yu Rongfang Zhao Xinying Lai Haijun Jiang Tianhong Xu Ying Zhao Rongfa Zhang |
| author_sort | Yun Wang |
| collection | DOAJ |
| description | In a neutral solution, we investigated the effects of Na<sub>2</sub>[ZnEDTA] concentrations at 0, 6, 12, 18, and 24 g/L on surface morphology, chemical composition, degradation resistance, and in vitro cytocompatibility of micro-arc oxidation (MAO) coatings developed on WE43 (Mg-Y-Nd-Zr) magnesium alloys. The results show that the enhanced Na<sub>2</sub>[ZnEDTA] concentration increased the Zn amount but slightly decreased the degradation resistance of MAO-treated coatings. Among the zinc-containing MAO samples, the fabricated sample in the base solution added 6 g/L Na<sub>2</sub>[ZnEDTA] exhibits the smallest corrosion current density (6.84 × 10<sup>−7</sup> A·cm<sup>−2</sup>), while the sample developed in the solution added 24 g/L Na<sub>2</sub>[ZnEDTA] and contains the highest Zn content (3.64 wt.%) but exhibits the largest corrosion current density (1.39 × 10<sup>−6</sup> A·cm<sup>−2</sup>). Compared to untreated WE43 magnesium alloys, zinc-containing MAO samples promote initial cell adhesion and spreading and reveal enhanced cell viability. Coating degradation resistance plays a more important role in osseogenic ability than Zn content. Among the untreated WE43 magnesium alloys and the treated MAO samples, the sample developed in the base solution with 6 g/L Na<sub>2</sub>[ZnEDTA] reveals the highest ALP expression at 14 d. Our results indicate that the MAO samples formed in the solution with Na<sub>2</sub>[ZnEDTA] promoted degradation resistance and osseogenesis differentiation of the WE43 magnesium alloys, suggesting potential clinic applications. |
| first_indexed | 2024-03-08T15:02:51Z |
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| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-08T15:02:51Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
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| series | Materials |
| spelling | doaj.art-d8526aac464e450d9417c004c1ff25962024-01-10T15:02:59ZengMDPI AGMaterials1996-19442023-12-0117120910.3390/ma17010209Investigation of In Vitro Cytocompatibility of Zinc-Containing Coatings Developed on Medical Magnesium AlloysYun Wang0Yuzhi Liu1Yuanyuan Zhu2Fanglei Yu3Rongfang Zhao4Xinying Lai5Haijun Jiang6Tianhong Xu7Ying Zhao8Rongfa Zhang9School of Materials and Energy, Jiangxi Science and Technology Normal University, Nanchang 330013, ChinaShenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, ChinaSchool of Materials and Energy, Jiangxi Science and Technology Normal University, Nanchang 330013, ChinaZhejiang Canwell Medical Co., Ltd., Jinhua 321000, ChinaSchool of Materials and Energy, Jiangxi Science and Technology Normal University, Nanchang 330013, ChinaSchool of Materials and Energy, Jiangxi Science and Technology Normal University, Nanchang 330013, ChinaSchool of Materials and Energy, Jiangxi Science and Technology Normal University, Nanchang 330013, ChinaSchool of Materials and Energy, Jiangxi Science and Technology Normal University, Nanchang 330013, ChinaShenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, ChinaSchool of Materials and Energy, Jiangxi Science and Technology Normal University, Nanchang 330013, ChinaIn a neutral solution, we investigated the effects of Na<sub>2</sub>[ZnEDTA] concentrations at 0, 6, 12, 18, and 24 g/L on surface morphology, chemical composition, degradation resistance, and in vitro cytocompatibility of micro-arc oxidation (MAO) coatings developed on WE43 (Mg-Y-Nd-Zr) magnesium alloys. The results show that the enhanced Na<sub>2</sub>[ZnEDTA] concentration increased the Zn amount but slightly decreased the degradation resistance of MAO-treated coatings. Among the zinc-containing MAO samples, the fabricated sample in the base solution added 6 g/L Na<sub>2</sub>[ZnEDTA] exhibits the smallest corrosion current density (6.84 × 10<sup>−7</sup> A·cm<sup>−2</sup>), while the sample developed in the solution added 24 g/L Na<sub>2</sub>[ZnEDTA] and contains the highest Zn content (3.64 wt.%) but exhibits the largest corrosion current density (1.39 × 10<sup>−6</sup> A·cm<sup>−2</sup>). Compared to untreated WE43 magnesium alloys, zinc-containing MAO samples promote initial cell adhesion and spreading and reveal enhanced cell viability. Coating degradation resistance plays a more important role in osseogenic ability than Zn content. Among the untreated WE43 magnesium alloys and the treated MAO samples, the sample developed in the base solution with 6 g/L Na<sub>2</sub>[ZnEDTA] reveals the highest ALP expression at 14 d. Our results indicate that the MAO samples formed in the solution with Na<sub>2</sub>[ZnEDTA] promoted degradation resistance and osseogenesis differentiation of the WE43 magnesium alloys, suggesting potential clinic applications.https://www.mdpi.com/1996-1944/17/1/209magnesium alloysMAO treatmentzinc-containing coatingsin vitro cytocompatibilitydegradation resistance |
| spellingShingle | Yun Wang Yuzhi Liu Yuanyuan Zhu Fanglei Yu Rongfang Zhao Xinying Lai Haijun Jiang Tianhong Xu Ying Zhao Rongfa Zhang Investigation of In Vitro Cytocompatibility of Zinc-Containing Coatings Developed on Medical Magnesium Alloys Materials magnesium alloys MAO treatment zinc-containing coatings in vitro cytocompatibility degradation resistance |
| title | Investigation of In Vitro Cytocompatibility of Zinc-Containing Coatings Developed on Medical Magnesium Alloys |
| title_full | Investigation of In Vitro Cytocompatibility of Zinc-Containing Coatings Developed on Medical Magnesium Alloys |
| title_fullStr | Investigation of In Vitro Cytocompatibility of Zinc-Containing Coatings Developed on Medical Magnesium Alloys |
| title_full_unstemmed | Investigation of In Vitro Cytocompatibility of Zinc-Containing Coatings Developed on Medical Magnesium Alloys |
| title_short | Investigation of In Vitro Cytocompatibility of Zinc-Containing Coatings Developed on Medical Magnesium Alloys |
| title_sort | investigation of in vitro cytocompatibility of zinc containing coatings developed on medical magnesium alloys |
| topic | magnesium alloys MAO treatment zinc-containing coatings in vitro cytocompatibility degradation resistance |
| url | https://www.mdpi.com/1996-1944/17/1/209 |
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