Aberrant expression and localization of the RAP1 shelterin protein contribute to age-related phenotypes
Short telomeres induce a DNA damage response (DDR) that evokes apoptosis and senescence in human cells. An extant question is the contribution of telomere dysfunction-induced DDR to the phenotypes observed in aging and telomere biology disorders. One candidate is RAP1, a telomere-associated protein...
Main Authors: | Amanda J. Stock, Ross A. McDevitt, Chandrakala Puligilla, Yajun Wang, Yongqing Zhang, Kun Wang, Chongkui Sun, Kevin G. Becker, Elin Lehrmann, William H. Wood, Yi Gong, Mohammad Aqdas, Myong-Hee Sung, Victoria Hoffmann, Chengyu Liu, Myriam Gorospe, Lea Harrington, Luigi Ferrucci, Yie Liu |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2022-11-01
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Series: | PLoS Genetics |
Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9704629/?tool=EBI |
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