Formation and glomerular deposition of immune complexes in mice administered bovine serum albumin: Evaluation of dose, frequency, and biomarkers

Formation and glomerular deposition of immune complexes in mice administered bovine serum albumin: Evaluation of dose, frequency, and biomarkers

In preclinical toxicity studies, species-foreign proteins administered to animals frequently leads to formation of anti-drug antibodies (ADA). Such antibodies may form circulating immune complexes (CIC) with the administered protein. These CIC can activate the classical complement pathway, thereby f...

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Bibliographic Details
Main Authors: Lykke Boysen, Birgitte M. Viuff, Lone H. Landsy, Shari A. Price, James T. Raymond, Jens Lykkesfeldt, Brian Lauritzen
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Journal of Immunotoxicology
Subjects:
mouse
immunogenicity
immune complex
bovine serum albumin
complement
Online Access:http://dx.doi.org/10.1080/1547691X.2019.1680776

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