Species-specific roles for the MAFA and MAFB transcription factors in regulating islet β cell identity

Species-specific roles for the MAFA and MAFB transcription factors in regulating islet β cell identity

Type 2 diabetes (T2D) is associated with compromised identity of insulin-producing pancreatic islet β cells, characterized by inappropriate production of other islet cell–enriched hormones. Here, we examined how hormone misexpression was influenced by the MAFA and MAFB transcription factors, closely...

Полное описание

Библиографические подробности
Главные авторы: Jeeyeon Cha, Xin Tong, Emily M. Walker, Tehila Dahan, Veronica A. Cochrane, Sudipta Ashe, Ronan Russell, Anna B. Osipovich, Alex M. Mawla, Min Guo, Jin-hua Liu, Zachary A. Loyd, Mark O. Huising, Mark A. Magnuson, Matthias Hebrok, Yuval Dor, Roland Stein
Формат: Статья
Язык:English
Опубликовано: American Society for Clinical investigation 2023-08-01
Серии:JCI Insight
Предметы:
Cell biology
Endocrinology
Online-ссылка:https://doi.org/10.1172/jci.insight.166386

Internet

https://doi.org/10.1172/jci.insight.166386

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