RNA Binding Proteins in the miRNA Pathway
microRNAs (miRNAs) are short ~22 nucleotides (nt) ribonucleic acids which post-transcriptionally regulate gene expression. miRNAs are key regulators of all cellular processes, and the correct expression of miRNAs in an organism is crucial for proper development and cellular function. As a result, th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-12-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1422-0067/17/1/31 |
| _version_ | 1811283032397578240 |
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| author | Patrick Connerty Alireza Ahadi Gyorgy Hutvagner |
| author_facet | Patrick Connerty Alireza Ahadi Gyorgy Hutvagner |
| author_sort | Patrick Connerty |
| collection | DOAJ |
| description | microRNAs (miRNAs) are short ~22 nucleotides (nt) ribonucleic acids which post-transcriptionally regulate gene expression. miRNAs are key regulators of all cellular processes, and the correct expression of miRNAs in an organism is crucial for proper development and cellular function. As a result, the miRNA biogenesis pathway is highly regulated. In this review, we outline the basic steps of miRNA biogenesis and miRNA mediated gene regulation focusing on the role of RNA binding proteins (RBPs). We also describe multiple mechanisms that regulate the canonical miRNA pathway, which depends on a wide range of RBPs. Moreover, we hypothesise that the interaction between miRNA regulation and RBPs is potentially more widespread based on the analysis of available high-throughput datasets. |
| first_indexed | 2024-04-13T02:03:17Z |
| format | Article |
| id | doaj.art-d85724d937034a8fa4418682e5d1c735 |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-13T02:03:17Z |
| publishDate | 2015-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-d85724d937034a8fa4418682e5d1c7352022-12-22T03:07:33ZengMDPI AGInternational Journal of Molecular Sciences1422-00672015-12-011713110.3390/ijms17010031ijms17010031RNA Binding Proteins in the miRNA PathwayPatrick Connerty0Alireza Ahadi1Gyorgy Hutvagner2Faculty of Science 1, University of Technology, Sydney, NSW 2007, AustraliaFaculty of Engineering and Information technology 2, University of Technology, Sydney, NSW 2007, AustraliaFaculty of Engineering and Information technology 2, University of Technology, Sydney, NSW 2007, AustraliamicroRNAs (miRNAs) are short ~22 nucleotides (nt) ribonucleic acids which post-transcriptionally regulate gene expression. miRNAs are key regulators of all cellular processes, and the correct expression of miRNAs in an organism is crucial for proper development and cellular function. As a result, the miRNA biogenesis pathway is highly regulated. In this review, we outline the basic steps of miRNA biogenesis and miRNA mediated gene regulation focusing on the role of RNA binding proteins (RBPs). We also describe multiple mechanisms that regulate the canonical miRNA pathway, which depends on a wide range of RBPs. Moreover, we hypothesise that the interaction between miRNA regulation and RBPs is potentially more widespread based on the analysis of available high-throughput datasets.http://www.mdpi.com/1422-0067/17/1/31miRNARNA binding proteinDroshaDicerArgonautecross-linking and immonoprecipitation (CLIP) |
| spellingShingle | Patrick Connerty Alireza Ahadi Gyorgy Hutvagner RNA Binding Proteins in the miRNA Pathway International Journal of Molecular Sciences miRNA RNA binding protein Drosha Dicer Argonaute cross-linking and immonoprecipitation (CLIP) |
| title | RNA Binding Proteins in the miRNA Pathway |
| title_full | RNA Binding Proteins in the miRNA Pathway |
| title_fullStr | RNA Binding Proteins in the miRNA Pathway |
| title_full_unstemmed | RNA Binding Proteins in the miRNA Pathway |
| title_short | RNA Binding Proteins in the miRNA Pathway |
| title_sort | rna binding proteins in the mirna pathway |
| topic | miRNA RNA binding protein Drosha Dicer Argonaute cross-linking and immonoprecipitation (CLIP) |
| url | http://www.mdpi.com/1422-0067/17/1/31 |
| work_keys_str_mv | AT patrickconnerty rnabindingproteinsinthemirnapathway AT alirezaahadi rnabindingproteinsinthemirnapathway AT gyorgyhutvagner rnabindingproteinsinthemirnapathway |