Severity of thyroid eye disease and type-2 diabetes mellitus: Is there a correlation?
Purpose: To study the correlation between thyroid eye disease (TED) with type-2 diabetes mellitus. Methods: A cross-sectional cohort study was conducted from Jan 2018 to Dec 2018, in patients presenting with thyroid eye disease to orbit and oculoplasty clinic of a tertiary eye care hospital. A total...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | Indian Journal of Ophthalmology |
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| Online Access: | http://www.ijo.in/article.asp?issn=0301-4738;year=2020;volume=68;issue=6;spage=1127;epage=1131;aulast=Ramamurthy |
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| author | Lakshmi B Ramamurthy Viji Rangarajan Neha Srirao Bindu Malini Renu Bansal Kavitha Yuvarajan |
| author_facet | Lakshmi B Ramamurthy Viji Rangarajan Neha Srirao Bindu Malini Renu Bansal Kavitha Yuvarajan |
| author_sort | Lakshmi B Ramamurthy |
| collection | DOAJ |
| description | Purpose: To study the correlation between thyroid eye disease (TED) with type-2 diabetes mellitus. Methods: A cross-sectional cohort study was conducted from Jan 2018 to Dec 2018, in patients presenting with thyroid eye disease to orbit and oculoplasty clinic of a tertiary eye care hospital. A total of 105 patients were included in the study. All patients underwent detailed ophthalmic evaluation and thyroid eye disease workup. Patients were categorized into mild, moderate, and severe/sight-threatening TED based on EUGOGO classification. Systemic history of diabetes was noted. RBS was done in all patients. Results: Mild disease was noted 61 patients of which 11 were diabetics, moderate in 26 patients (8 diabetics), and severe disease in 18 patients (14 diabetics). All patients were treated accordingly. Among the TED patients, the percentage of diabetic patients was noted to be in increasing order toward the severity spectrum of TED. The prevalence of severe TED was found to be much higher in diabetic patients accounting upto 77.77% of 18 patients. A statistically significant correlation was noted (P = 0.014) between severe TED and type-2 diabetes mellitus. In addition, early onset of thyroid eye disease was noted in type-2 diabetes patients. Even though female preponderance was noted, severe TED was more in men (66.6%). Conclusion: An autoimmune etiology for the association of thyroid and type-1diabetes has been well established. This study shows that type-2 diabetic patients can have more severity in the clinical presentation of TED. Therefore, the presence of type-2 DM in patients with TED can be a predictive factor for onset, progression, and severity of disease. Hence, a high concern of interest among treating ophthalmologists and endocrinologists regarding this entity would help in early prediction and decreased morbidity among such patients. |
| first_indexed | 2024-12-10T08:55:26Z |
| format | Article |
| id | doaj.art-d85881a4b7b54813ba3e3a07b8815bc1 |
| institution | Directory Open Access Journal |
| issn | 0301-4738 1998-3689 |
| language | English |
| last_indexed | 2024-12-10T08:55:26Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj.art-d85881a4b7b54813ba3e3a07b8815bc12022-12-22T01:55:26ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892020-01-016861127113110.4103/ijo.IJO_1443_19Severity of thyroid eye disease and type-2 diabetes mellitus: Is there a correlation?Lakshmi B RamamurthyViji RangarajanNeha SriraoBindu MaliniRenu BansalKavitha YuvarajanPurpose: To study the correlation between thyroid eye disease (TED) with type-2 diabetes mellitus. Methods: A cross-sectional cohort study was conducted from Jan 2018 to Dec 2018, in patients presenting with thyroid eye disease to orbit and oculoplasty clinic of a tertiary eye care hospital. A total of 105 patients were included in the study. All patients underwent detailed ophthalmic evaluation and thyroid eye disease workup. Patients were categorized into mild, moderate, and severe/sight-threatening TED based on EUGOGO classification. Systemic history of diabetes was noted. RBS was done in all patients. Results: Mild disease was noted 61 patients of which 11 were diabetics, moderate in 26 patients (8 diabetics), and severe disease in 18 patients (14 diabetics). All patients were treated accordingly. Among the TED patients, the percentage of diabetic patients was noted to be in increasing order toward the severity spectrum of TED. The prevalence of severe TED was found to be much higher in diabetic patients accounting upto 77.77% of 18 patients. A statistically significant correlation was noted (P = 0.014) between severe TED and type-2 diabetes mellitus. In addition, early onset of thyroid eye disease was noted in type-2 diabetes patients. Even though female preponderance was noted, severe TED was more in men (66.6%). Conclusion: An autoimmune etiology for the association of thyroid and type-1diabetes has been well established. This study shows that type-2 diabetic patients can have more severity in the clinical presentation of TED. Therefore, the presence of type-2 DM in patients with TED can be a predictive factor for onset, progression, and severity of disease. Hence, a high concern of interest among treating ophthalmologists and endocrinologists regarding this entity would help in early prediction and decreased morbidity among such patients.http://www.ijo.in/article.asp?issn=0301-4738;year=2020;volume=68;issue=6;spage=1127;epage=1131;aulast=Ramamurthydiabetes mellitusthyroid eye diseasethyroid-related orbitopathytype-2 dm |
| spellingShingle | Lakshmi B Ramamurthy Viji Rangarajan Neha Srirao Bindu Malini Renu Bansal Kavitha Yuvarajan Severity of thyroid eye disease and type-2 diabetes mellitus: Is there a correlation? Indian Journal of Ophthalmology diabetes mellitus thyroid eye disease thyroid-related orbitopathy type-2 dm |
| title | Severity of thyroid eye disease and type-2 diabetes mellitus: Is there a correlation? |
| title_full | Severity of thyroid eye disease and type-2 diabetes mellitus: Is there a correlation? |
| title_fullStr | Severity of thyroid eye disease and type-2 diabetes mellitus: Is there a correlation? |
| title_full_unstemmed | Severity of thyroid eye disease and type-2 diabetes mellitus: Is there a correlation? |
| title_short | Severity of thyroid eye disease and type-2 diabetes mellitus: Is there a correlation? |
| title_sort | severity of thyroid eye disease and type 2 diabetes mellitus is there a correlation |
| topic | diabetes mellitus thyroid eye disease thyroid-related orbitopathy type-2 dm |
| url | http://www.ijo.in/article.asp?issn=0301-4738;year=2020;volume=68;issue=6;spage=1127;epage=1131;aulast=Ramamurthy |
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