Synbiological systems for complex natural products biosynthesis
Natural products (NPs) continue to play a pivotal role in drug discovery programs. The rapid development of synthetic biology has conferred the strategies of NPs production. Synthetic biology is a new engineering discipline that aims to produce desirable products by rationally programming the biolog...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2016-12-01
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| Series: | Synthetic and Systems Biotechnology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405805X16300412 |
| _version_ | 1797204969606086656 |
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| author | Jianhua Li Hailin Meng Yong Wang |
| author_facet | Jianhua Li Hailin Meng Yong Wang |
| author_sort | Jianhua Li |
| collection | DOAJ |
| description | Natural products (NPs) continue to play a pivotal role in drug discovery programs. The rapid development of synthetic biology has conferred the strategies of NPs production. Synthetic biology is a new engineering discipline that aims to produce desirable products by rationally programming the biological parts and manipulating the pathways. However, there is still a challenge for integrating a heterologous pathway in chassis cells for overproduction purpose due to the limited characterized parts, modules incompatibility, and cell tolerance towards product. Enormous endeavors have been taken for mentioned issues. Herein, in this review, the progresses in naturally discovering novel biological parts and rational design of synthetic biological parts are reviewed, combining with the advanced assembly technologies, pathway engineering, and pathway optimization in global network guidance. The future perspectives are also presented. |
| first_indexed | 2024-04-24T08:43:40Z |
| format | Article |
| id | doaj.art-d85977e0a2104954bd3f28a5d9b16fd6 |
| institution | Directory Open Access Journal |
| issn | 2405-805X |
| language | English |
| last_indexed | 2024-04-24T08:43:40Z |
| publishDate | 2016-12-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Synthetic and Systems Biotechnology |
| spelling | doaj.art-d85977e0a2104954bd3f28a5d9b16fd62024-04-16T14:48:58ZengKeAi Communications Co., Ltd.Synthetic and Systems Biotechnology2405-805X2016-12-011422122910.1016/j.synbio.2016.08.002Synbiological systems for complex natural products biosynthesisJianhua Li0Hailin Meng1Yong Wang2Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, ChinaBioengineering Research Center, Guangzhou Institute of Advanced Technology, Chinese Academy of Sciences, Guangzhou 511458, ChinaKey Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, ChinaNatural products (NPs) continue to play a pivotal role in drug discovery programs. The rapid development of synthetic biology has conferred the strategies of NPs production. Synthetic biology is a new engineering discipline that aims to produce desirable products by rationally programming the biological parts and manipulating the pathways. However, there is still a challenge for integrating a heterologous pathway in chassis cells for overproduction purpose due to the limited characterized parts, modules incompatibility, and cell tolerance towards product. Enormous endeavors have been taken for mentioned issues. Herein, in this review, the progresses in naturally discovering novel biological parts and rational design of synthetic biological parts are reviewed, combining with the advanced assembly technologies, pathway engineering, and pathway optimization in global network guidance. The future perspectives are also presented.http://www.sciencedirect.com/science/article/pii/S2405805X16300412Natural productsSynbiological systemSynthetic biologyBiological partsSystematic optimization |
| spellingShingle | Jianhua Li Hailin Meng Yong Wang Synbiological systems for complex natural products biosynthesis Synthetic and Systems Biotechnology Natural products Synbiological system Synthetic biology Biological parts Systematic optimization |
| title | Synbiological systems for complex natural products biosynthesis |
| title_full | Synbiological systems for complex natural products biosynthesis |
| title_fullStr | Synbiological systems for complex natural products biosynthesis |
| title_full_unstemmed | Synbiological systems for complex natural products biosynthesis |
| title_short | Synbiological systems for complex natural products biosynthesis |
| title_sort | synbiological systems for complex natural products biosynthesis |
| topic | Natural products Synbiological system Synthetic biology Biological parts Systematic optimization |
| url | http://www.sciencedirect.com/science/article/pii/S2405805X16300412 |
| work_keys_str_mv | AT jianhuali synbiologicalsystemsforcomplexnaturalproductsbiosynthesis AT hailinmeng synbiologicalsystemsforcomplexnaturalproductsbiosynthesis AT yongwang synbiologicalsystemsforcomplexnaturalproductsbiosynthesis |