CAPECITABINE IN THE TREATMENT OF BRAIN METASTATIC LESION IN PATIENTS WITH BREAST CANCER
The paper considers the experience with capecitabine in 67 patients with brain metastatic lesion from breast cancer. The immediate efficacy of capecitabine and the results of therapy with the agent were analyzed in the groups of its use alone and in combination with radiotherapy both for therapeutic...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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ABV-press
2015-04-01
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| Series: | Опухоли головы и шеи |
| Subjects: | |
| Online Access: | https://ogsh.abvpress.ru/jour/article/view/86 |
| _version_ | 1797876246028222464 |
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| author | E. A. Moskvina V. A. Gorbunova D. R. Naskhletashvili A. Kh. Bekyashev S. V. Medvedev S. B. Peterson |
| author_facet | E. A. Moskvina V. A. Gorbunova D. R. Naskhletashvili A. Kh. Bekyashev S. V. Medvedev S. B. Peterson |
| author_sort | E. A. Moskvina |
| collection | DOAJ |
| description | The paper considers the experience with capecitabine in 67 patients with brain metastatic lesion from breast cancer. The immediate efficacy of capecitabine and the results of therapy with the agent were analyzed in the groups of its use alone and in combination with radiotherapy both for therapeutic purposes and as an adjuvant regimen. In the chemoradiation therapy group, the objective effects in the brain were 73 %. The median time to progression was 12.27 months. In the monochemotherapy group, the objective effects were 30 %. The median time to progression was 4 months. The results of the investigation show that capecitabine has pronounced antitumor activity and moderate toxicity. Combination treatment is the method of choice. |
| first_indexed | 2024-04-10T02:00:13Z |
| format | Article |
| id | doaj.art-d85ad686fabd41758317eb4702f940bb |
| institution | Directory Open Access Journal |
| issn | 2222-1468 2411-4634 |
| language | Russian |
| last_indexed | 2024-04-10T02:00:13Z |
| publishDate | 2015-04-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли головы и шеи |
| spelling | doaj.art-d85ad686fabd41758317eb4702f940bb2023-03-13T08:43:17ZrusABV-pressОпухоли головы и шеи2222-14682411-46342015-04-0103596210.17650/2222-1468-2012-0-3-59-6286CAPECITABINE IN THE TREATMENT OF BRAIN METASTATIC LESION IN PATIENTS WITH BREAST CANCERE. A. Moskvina0V. A. Gorbunova1D. R. Naskhletashvili2A. Kh. Bekyashev3S. V. Medvedev4S. B. Peterson5ФГБНУ «Российский онкологический научный центр им. Н.Н. Блохина» РАМН, МоскваФГБНУ «Российский онкологический научный центр им. Н.Н. Блохина» РАМН, МоскваФГБНУ «Российский онкологический научный центр им. Н.Н. Блохина» РАМН, МоскваФГБНУ «Российский онкологический научный центр им. Н.Н. Блохина» РАМН, Москва; ГБОУ ДПО «Российская медицинская академия последипломного образования» Минздрава России, МоскваФГБНУ «Российский онкологический научный центр им. Н.Н. Блохина» РАМН, МоскваФГБНУ «Российский онкологический научный центр им. Н.Н. Блохина» РАМН, МоскваThe paper considers the experience with capecitabine in 67 patients with brain metastatic lesion from breast cancer. The immediate efficacy of capecitabine and the results of therapy with the agent were analyzed in the groups of its use alone and in combination with radiotherapy both for therapeutic purposes and as an adjuvant regimen. In the chemoradiation therapy group, the objective effects in the brain were 73 %. The median time to progression was 12.27 months. In the monochemotherapy group, the objective effects were 30 %. The median time to progression was 4 months. The results of the investigation show that capecitabine has pronounced antitumor activity and moderate toxicity. Combination treatment is the method of choice.https://ogsh.abvpress.ru/jour/article/view/86метастазы в головном мозгерак молочной железыкапецитабинлучевая терапия |
| spellingShingle | E. A. Moskvina V. A. Gorbunova D. R. Naskhletashvili A. Kh. Bekyashev S. V. Medvedev S. B. Peterson CAPECITABINE IN THE TREATMENT OF BRAIN METASTATIC LESION IN PATIENTS WITH BREAST CANCER Опухоли головы и шеи метастазы в головном мозге рак молочной железы капецитабин лучевая терапия |
| title | CAPECITABINE IN THE TREATMENT OF BRAIN METASTATIC LESION IN PATIENTS WITH BREAST CANCER |
| title_full | CAPECITABINE IN THE TREATMENT OF BRAIN METASTATIC LESION IN PATIENTS WITH BREAST CANCER |
| title_fullStr | CAPECITABINE IN THE TREATMENT OF BRAIN METASTATIC LESION IN PATIENTS WITH BREAST CANCER |
| title_full_unstemmed | CAPECITABINE IN THE TREATMENT OF BRAIN METASTATIC LESION IN PATIENTS WITH BREAST CANCER |
| title_short | CAPECITABINE IN THE TREATMENT OF BRAIN METASTATIC LESION IN PATIENTS WITH BREAST CANCER |
| title_sort | capecitabine in the treatment of brain metastatic lesion in patients with breast cancer |
| topic | метастазы в головном мозге рак молочной железы капецитабин лучевая терапия |
| url | https://ogsh.abvpress.ru/jour/article/view/86 |
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