Transitioning between preparatory and precisely sequenced neuronal activity in production of a skilled behavior
Precise neural sequences are associated with the production of well-learned skilled behaviors. Yet, how neural sequences arise in the brain remains unclear. In songbirds, premotor projection neurons in the cortical song nucleus HVC are necessary for producing learned song and exhibit precise sequent...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2019-06-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/43732 |
| _version_ | 1811180570427785216 |
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| author | Vamsi K Daliparthi Ryosuke O Tachibana Brenton G Cooper Richard HR Hahnloser Satoshi Kojima Samuel J Sober Todd F Roberts |
| author_facet | Vamsi K Daliparthi Ryosuke O Tachibana Brenton G Cooper Richard HR Hahnloser Satoshi Kojima Samuel J Sober Todd F Roberts |
| author_sort | Vamsi K Daliparthi |
| collection | DOAJ |
| description | Precise neural sequences are associated with the production of well-learned skilled behaviors. Yet, how neural sequences arise in the brain remains unclear. In songbirds, premotor projection neurons in the cortical song nucleus HVC are necessary for producing learned song and exhibit precise sequential activity during singing. Using cell-type specific calcium imaging we identify populations of HVC premotor neurons associated with the beginning and ending of singing-related neural sequences. We characterize neurons that bookend singing-related sequences and neuronal populations that transition from sparse preparatory activity prior to song to precise neural sequences during singing. Recordings from downstream premotor neurons or the respiratory system suggest that pre-song activity may be involved in motor preparation to sing. These findings reveal population mechanisms associated with moving from non-vocal to vocal behavioral states and suggest that precise neural sequences begin and end as part of orchestrated activity across functionally diverse populations of cortical premotor neurons. |
| first_indexed | 2024-04-11T09:04:17Z |
| format | Article |
| id | doaj.art-d85ca5c9feed486f83eca73d2f493af7 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-11T09:04:17Z |
| publishDate | 2019-06-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-d85ca5c9feed486f83eca73d2f493af72022-12-22T04:32:40ZengeLife Sciences Publications LtdeLife2050-084X2019-06-01810.7554/eLife.43732Transitioning between preparatory and precisely sequenced neuronal activity in production of a skilled behaviorVamsi K Daliparthi0https://orcid.org/0000-0001-6358-729XRyosuke O Tachibana1https://orcid.org/0000-0002-4766-4504Brenton G Cooper2https://orcid.org/0000-0002-3572-8822Richard HR Hahnloser3https://orcid.org/0000-0002-4039-7773Satoshi Kojima4https://orcid.org/0000-0002-0753-4238Samuel J Sober5https://orcid.org/0000-0002-1140-7469Todd F Roberts6https://orcid.org/0000-0002-0967-6598Department of Neuroscience, UT Southwestern Medical Center, Dallas, United StatesDepartment of Life Sciences, The University of Tokyo, Tokyo, Japan; Institute of Neuroinformatics, University of Zurich/ETH Zurich, Zurich, SwitzerlandDepartment of Psychology, Texas Christian University, Fort Worth, United StatesInstitute of Neuroinformatics, University of Zurich/ETH Zurich, Zurich, Switzerland; Neuroscience Center Zurich (ZNZ), Zurich, SwitzerlandDepartment of Structure and Function of Neural Network, Korea Brain Research Institute, Daegu, Republic of KoreaDepartment of Biology, Emory University, Atlanta, United StatesDepartment of Neuroscience, UT Southwestern Medical Center, Dallas, United StatesPrecise neural sequences are associated with the production of well-learned skilled behaviors. Yet, how neural sequences arise in the brain remains unclear. In songbirds, premotor projection neurons in the cortical song nucleus HVC are necessary for producing learned song and exhibit precise sequential activity during singing. Using cell-type specific calcium imaging we identify populations of HVC premotor neurons associated with the beginning and ending of singing-related neural sequences. We characterize neurons that bookend singing-related sequences and neuronal populations that transition from sparse preparatory activity prior to song to precise neural sequences during singing. Recordings from downstream premotor neurons or the respiratory system suggest that pre-song activity may be involved in motor preparation to sing. These findings reveal population mechanisms associated with moving from non-vocal to vocal behavioral states and suggest that precise neural sequences begin and end as part of orchestrated activity across functionally diverse populations of cortical premotor neurons.https://elifesciences.org/articles/43732songbirdHVCmotor planningneuronal sequencesmotor controlvocalization |
| spellingShingle | Vamsi K Daliparthi Ryosuke O Tachibana Brenton G Cooper Richard HR Hahnloser Satoshi Kojima Samuel J Sober Todd F Roberts Transitioning between preparatory and precisely sequenced neuronal activity in production of a skilled behavior eLife songbird HVC motor planning neuronal sequences motor control vocalization |
| title | Transitioning between preparatory and precisely sequenced neuronal activity in production of a skilled behavior |
| title_full | Transitioning between preparatory and precisely sequenced neuronal activity in production of a skilled behavior |
| title_fullStr | Transitioning between preparatory and precisely sequenced neuronal activity in production of a skilled behavior |
| title_full_unstemmed | Transitioning between preparatory and precisely sequenced neuronal activity in production of a skilled behavior |
| title_short | Transitioning between preparatory and precisely sequenced neuronal activity in production of a skilled behavior |
| title_sort | transitioning between preparatory and precisely sequenced neuronal activity in production of a skilled behavior |
| topic | songbird HVC motor planning neuronal sequences motor control vocalization |
| url | https://elifesciences.org/articles/43732 |
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