Plasma Calcium Level and C-Reactive Protein Albumin Ratio Affect Severe Bleeding After Coronary Artery Bypass Grafting
ABSTRACT Objective: In this study, we aimed to determine whether plasma calcium level and C-reactive protein albumin ratio (CAR) as well as other demographic and hematological markers are related in predicting severe bleeding after coronary artery bypass grafting (CABG). Methods: A total of 227 ad...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Cirurgia Cardiovascular
2023-07-01
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| Series: | Brazilian Journal of Cardiovascular Surgery |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382023000400206&tlng=en |
| _version_ | 1797783336926576640 |
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| author | Serdar Badem Ahmet Yuksel Ali Onder Kilic Atilla Pekcolaklar Nofel Ahmet Binicier Demir Cetintas Mehmet Coskun Haluk Mevre Ozgoz Yusuf Velioglu |
| author_facet | Serdar Badem Ahmet Yuksel Ali Onder Kilic Atilla Pekcolaklar Nofel Ahmet Binicier Demir Cetintas Mehmet Coskun Haluk Mevre Ozgoz Yusuf Velioglu |
| author_sort | Serdar Badem |
| collection | DOAJ |
| description | ABSTRACT Objective: In this study, we aimed to determine whether plasma calcium level and C-reactive protein albumin ratio (CAR) as well as other demographic and hematological markers are related in predicting severe bleeding after coronary artery bypass grafting (CABG). Methods: A total of 227 adult patients who underwent CABG at our hospital between December 2021 and June 2022 were prospectively studied. Total amount of chest tube drainage was evaluated within the first 24 hours postoperatively or until the patient was re-explored for bleeding. The patients were divided into two groups - Group 1, patients with low amount of bleeding (n=174), and Group 2, patients with severe bleeding (n=53). Univariate and multivariate regression analyzes were performed to determine independent parameters related to severe bleeding within the first 24 hours after surgery. Results: When the groups were compared in terms of demographic, clinical, and preoperative blood parameters; cardiopulmonary bypass time and serum C-reactive protein (CRP) levels were found to be significantly higher in Group 2 compared to the low bleeding group. In addition, lymphocytes, hemoglobin, calcium, albumin, and CAR were found to be significantly lower in Group 2. In multivariate analysis, calcium, albumin, CRP, and CAR were found to be independent predictors of significant association with excessive bleeding. A cut-off value of 8.7 (94.3% sensitivity and 94.8% specificity) for calcium and 0.155 (75.4% sensitivity and 80.4% specificity) for CAR predicted excessive bleeding. Conclusion: Plasma calcium level, CRP, albumin, and CAR can be used to predict severe bleeding after CABG. |
| first_indexed | 2024-03-13T00:24:36Z |
| format | Article |
| id | doaj.art-d8637f7713204a1b97f4d18eeae5f09f |
| institution | Directory Open Access Journal |
| issn | 1678-9741 |
| language | English |
| last_indexed | 2024-03-13T00:24:36Z |
| publishDate | 2023-07-01 |
| publisher | Sociedade Brasileira de Cirurgia Cardiovascular |
| record_format | Article |
| series | Brazilian Journal of Cardiovascular Surgery |
| spelling | doaj.art-d8637f7713204a1b97f4d18eeae5f09f2023-07-11T07:51:02ZengSociedade Brasileira de Cirurgia CardiovascularBrazilian Journal of Cardiovascular Surgery1678-97412023-07-0138410.21470/1678-9741-2022-0378Plasma Calcium Level and C-Reactive Protein Albumin Ratio Affect Severe Bleeding After Coronary Artery Bypass GraftingSerdar BademAhmet YukselAli Onder KilicAtilla PekcolaklarNofel Ahmet BinicierDemir CetintasMehmet CoskunHaluk Mevre OzgozYusuf VeliogluABSTRACT Objective: In this study, we aimed to determine whether plasma calcium level and C-reactive protein albumin ratio (CAR) as well as other demographic and hematological markers are related in predicting severe bleeding after coronary artery bypass grafting (CABG). Methods: A total of 227 adult patients who underwent CABG at our hospital between December 2021 and June 2022 were prospectively studied. Total amount of chest tube drainage was evaluated within the first 24 hours postoperatively or until the patient was re-explored for bleeding. The patients were divided into two groups - Group 1, patients with low amount of bleeding (n=174), and Group 2, patients with severe bleeding (n=53). Univariate and multivariate regression analyzes were performed to determine independent parameters related to severe bleeding within the first 24 hours after surgery. Results: When the groups were compared in terms of demographic, clinical, and preoperative blood parameters; cardiopulmonary bypass time and serum C-reactive protein (CRP) levels were found to be significantly higher in Group 2 compared to the low bleeding group. In addition, lymphocytes, hemoglobin, calcium, albumin, and CAR were found to be significantly lower in Group 2. In multivariate analysis, calcium, albumin, CRP, and CAR were found to be independent predictors of significant association with excessive bleeding. A cut-off value of 8.7 (94.3% sensitivity and 94.8% specificity) for calcium and 0.155 (75.4% sensitivity and 80.4% specificity) for CAR predicted excessive bleeding. Conclusion: Plasma calcium level, CRP, albumin, and CAR can be used to predict severe bleeding after CABG.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382023000400206&tlng=enCalciumCoronary Artery BypassChest TubesAlbuminsDrainageHematologic DiseasesC-Reactive Protein |
| spellingShingle | Serdar Badem Ahmet Yuksel Ali Onder Kilic Atilla Pekcolaklar Nofel Ahmet Binicier Demir Cetintas Mehmet Coskun Haluk Mevre Ozgoz Yusuf Velioglu Plasma Calcium Level and C-Reactive Protein Albumin Ratio Affect Severe Bleeding After Coronary Artery Bypass Grafting Brazilian Journal of Cardiovascular Surgery Calcium Coronary Artery Bypass Chest Tubes Albumins Drainage Hematologic Diseases C-Reactive Protein |
| title | Plasma Calcium Level and C-Reactive Protein Albumin Ratio Affect Severe Bleeding After Coronary Artery Bypass Grafting |
| title_full | Plasma Calcium Level and C-Reactive Protein Albumin Ratio Affect Severe Bleeding After Coronary Artery Bypass Grafting |
| title_fullStr | Plasma Calcium Level and C-Reactive Protein Albumin Ratio Affect Severe Bleeding After Coronary Artery Bypass Grafting |
| title_full_unstemmed | Plasma Calcium Level and C-Reactive Protein Albumin Ratio Affect Severe Bleeding After Coronary Artery Bypass Grafting |
| title_short | Plasma Calcium Level and C-Reactive Protein Albumin Ratio Affect Severe Bleeding After Coronary Artery Bypass Grafting |
| title_sort | plasma calcium level and c reactive protein albumin ratio affect severe bleeding after coronary artery bypass grafting |
| topic | Calcium Coronary Artery Bypass Chest Tubes Albumins Drainage Hematologic Diseases C-Reactive Protein |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382023000400206&tlng=en |
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