THE INTENSITY OF SYSTEMIC INFLAMMATION RESPONSE IN THOSE SUFFERING FROM HIV-ASSOCIATED TUBERCULOSIS
238 tuberculosis cases with concurrent HIV infection were examined. The age of patients varied from 24 to 57 years old. Men made 189 (79.4%), and women 49 (20.6%). The CD4 count in the examined patients varied from 0 to 1.216 × 109/L. The intensity of systematic inflammatory response was evaluated ...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2017-06-01
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| Series: | Туберкулез и болезни лёгких |
| Subjects: | |
| Online Access: | https://www.tibl-journal.com/jour/article/view/1011 |
| _version_ | 1797700231981170688 |
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| author | R. Yu. Аbdullаev O. G. Komissаrovа L. N. Gerаsimov |
| author_facet | R. Yu. Аbdullаev O. G. Komissаrovа L. N. Gerаsimov |
| author_sort | R. Yu. Аbdullаev |
| collection | DOAJ |
| description | 238 tuberculosis cases with concurrent HIV infection were examined. The age of patients varied from 24 to 57 years old. Men made 189 (79.4%), and women 49 (20.6%). The CD4 count in the examined patients varied from 0 to 1.216 × 109/L. The intensity of systematic inflammatory response was evaluated as per the rates of acute phase reactants: С-reactive protein (СRP), α1-antitrypsin (α1-АТ), haptoglobin (HG) and fibrinogen (F). It was found out that tuberculosis patients with concurrent HIV infection demonstrated confidently increased levels of C-reactive protein, α1-antitrypsin, and haptoglobin, which was the evidence of systemic inflammatory response. However, the increase of fibrinogen level was not typical of tuberculosis patients with concurrent HIV infection. The comparative analysis proved that the intensity of systemic inflammatory response was increasing simultaneously with the severity of the immune deficiency, and the growth of acute phase reactants' level with a parallel reduction of CD4 count was the evidence of the above. C-reactive protein and α1-antitrypsin were the most informative markers of systemic inflammatory response intensity in tuberculosis patients with concurrent HIV infection. |
| first_indexed | 2024-03-12T04:19:25Z |
| format | Article |
| id | doaj.art-d864737ff22c48a7804029a61a2c8e42 |
| institution | Directory Open Access Journal |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| last_indexed | 2024-03-12T04:19:25Z |
| publishDate | 2017-06-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj.art-d864737ff22c48a7804029a61a2c8e422023-09-03T10:34:26ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062017-06-01956364010.21292/2075-1230-2017-95-6-36-401011THE INTENSITY OF SYSTEMIC INFLAMMATION RESPONSE IN THOSE SUFFERING FROM HIV-ASSOCIATED TUBERCULOSISR. Yu. Аbdullаev0O. G. Komissаrovа1L. N. Gerаsimov2ФГБНУ «Центральный научно-исследовательский институт туберкулеза»ФГБНУ «Центральный научно-исследовательский институт туберкулеза»; Российский национальный исследовательский медицинский университет им. Н.И. ПироговаФГБНУ «Центральный научно-исследовательский институт туберкулеза»; Туберкулезная больница им. А.Е. Рабухина238 tuberculosis cases with concurrent HIV infection were examined. The age of patients varied from 24 to 57 years old. Men made 189 (79.4%), and women 49 (20.6%). The CD4 count in the examined patients varied from 0 to 1.216 × 109/L. The intensity of systematic inflammatory response was evaluated as per the rates of acute phase reactants: С-reactive protein (СRP), α1-antitrypsin (α1-АТ), haptoglobin (HG) and fibrinogen (F). It was found out that tuberculosis patients with concurrent HIV infection demonstrated confidently increased levels of C-reactive protein, α1-antitrypsin, and haptoglobin, which was the evidence of systemic inflammatory response. However, the increase of fibrinogen level was not typical of tuberculosis patients with concurrent HIV infection. The comparative analysis proved that the intensity of systemic inflammatory response was increasing simultaneously with the severity of the immune deficiency, and the growth of acute phase reactants' level with a parallel reduction of CD4 count was the evidence of the above. C-reactive protein and α1-antitrypsin were the most informative markers of systemic inflammatory response intensity in tuberculosis patients with concurrent HIV infection.https://www.tibl-journal.com/jour/article/view/1011туберкулезвич-инфекциябелки острой фазысистемный воспалительный ответ |
| spellingShingle | R. Yu. Аbdullаev O. G. Komissаrovа L. N. Gerаsimov THE INTENSITY OF SYSTEMIC INFLAMMATION RESPONSE IN THOSE SUFFERING FROM HIV-ASSOCIATED TUBERCULOSIS Туберкулез и болезни лёгких туберкулез вич-инфекция белки острой фазы системный воспалительный ответ |
| title | THE INTENSITY OF SYSTEMIC INFLAMMATION RESPONSE IN THOSE SUFFERING FROM HIV-ASSOCIATED TUBERCULOSIS |
| title_full | THE INTENSITY OF SYSTEMIC INFLAMMATION RESPONSE IN THOSE SUFFERING FROM HIV-ASSOCIATED TUBERCULOSIS |
| title_fullStr | THE INTENSITY OF SYSTEMIC INFLAMMATION RESPONSE IN THOSE SUFFERING FROM HIV-ASSOCIATED TUBERCULOSIS |
| title_full_unstemmed | THE INTENSITY OF SYSTEMIC INFLAMMATION RESPONSE IN THOSE SUFFERING FROM HIV-ASSOCIATED TUBERCULOSIS |
| title_short | THE INTENSITY OF SYSTEMIC INFLAMMATION RESPONSE IN THOSE SUFFERING FROM HIV-ASSOCIATED TUBERCULOSIS |
| title_sort | intensity of systemic inflammation response in those suffering from hiv associated tuberculosis |
| topic | туберкулез вич-инфекция белки острой фазы системный воспалительный ответ |
| url | https://www.tibl-journal.com/jour/article/view/1011 |
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