Curative Effects of Pomegranate and Ginger on Hepatic and Renal Functions of Indomethacin-Induced Peptic Ulcers in Albino Rats
A peptic ulcer is one of the more severe diseases and most classic treatment protocol produce adverse drug reactions. Therefore, this study aimed to examine the therapeutic effects of two natural extracts, namely Pomegranate and Ginger, on indomethacin-induced gastric ulcer in rats. Animals were div...
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| Format: | Article |
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University of Zakho
2017-03-01
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| Series: | Science Journal of University of Zakho |
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| Online Access: | https://sjuoz.uoz.edu.krd/index.php/sjuoz/article/view/461 |
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| author | Mudhir S. Shekha Muhsin J. Abdulwahid Peshraw S. Hamadamin Trifa F. Ismail Saman R. Hamad Bakir Laween M. Ibrahim Lana M. Ahmed |
| author_facet | Mudhir S. Shekha Muhsin J. Abdulwahid Peshraw S. Hamadamin Trifa F. Ismail Saman R. Hamad Bakir Laween M. Ibrahim Lana M. Ahmed |
| author_sort | Mudhir S. Shekha |
| collection | DOAJ |
| description | A peptic ulcer is one of the more severe diseases and most classic treatment protocol produce adverse drug reactions. Therefore, this study aimed to examine the therapeutic effects of two natural extracts, namely Pomegranate and Ginger, on indomethacin-induced gastric ulcer in rats. Animals were divided into five groups; 1. Normal control group, 2. An ulcer control group Indomethacin (0.3 mg /rats), 3. Omeprazole (3 mg /rats), a4. Pomegranate (40 mg /rats), 5. Ginger (20 mg /rats). The ulcers were induced made from groups 2 - 5 by oral administration of Indomethacin. Rats subjected to indomethacin administration showed significant ulceration in the glandular area of their stomachs compared to normal control rats. In addition, significant elevations S.GPT, S.GOT, S. creatinine and S. Urea (P< 0.05) were observed. Alternatively, pretreatment with pomegranate and ginger significantly corrected macroscopic and biochemical parameters. These results demonstrate that administration of either pomegranate and ginger supplementation have an essential role in the prevention of ulceration induced by NSAIDs. Furthermore improved liver and kidney functions and reduced hepatoto and nephrotoxicities. |
| first_indexed | 2024-12-11T12:08:23Z |
| format | Article |
| id | doaj.art-d86677e3166646f48647334b0c0854d1 |
| institution | Directory Open Access Journal |
| issn | 2663-628X 2663-6298 |
| language | English |
| last_indexed | 2024-12-11T12:08:23Z |
| publishDate | 2017-03-01 |
| publisher | University of Zakho |
| record_format | Article |
| series | Science Journal of University of Zakho |
| spelling | doaj.art-d86677e3166646f48647334b0c0854d12022-12-22T01:07:52ZengUniversity of ZakhoScience Journal of University of Zakho2663-628X2663-62982017-03-0151485210.25271/2017.5.1.300461Curative Effects of Pomegranate and Ginger on Hepatic and Renal Functions of Indomethacin-Induced Peptic Ulcers in Albino RatsMudhir S. Shekha0Muhsin J. Abdulwahid1Peshraw S. Hamadamin2Trifa F. Ismail3Saman R. Hamad Bakir4Laween M. Ibrahim5Lana M. Ahmed6Salahaddin UniversitySalahaddin UniversitySalahaddin UniversitySalahaddin UniversityErbil Directorate General of Health, Ministry of Health.Erbil Directorate General of Health, Ministry of HealthSalahaddin UniversityA peptic ulcer is one of the more severe diseases and most classic treatment protocol produce adverse drug reactions. Therefore, this study aimed to examine the therapeutic effects of two natural extracts, namely Pomegranate and Ginger, on indomethacin-induced gastric ulcer in rats. Animals were divided into five groups; 1. Normal control group, 2. An ulcer control group Indomethacin (0.3 mg /rats), 3. Omeprazole (3 mg /rats), a4. Pomegranate (40 mg /rats), 5. Ginger (20 mg /rats). The ulcers were induced made from groups 2 - 5 by oral administration of Indomethacin. Rats subjected to indomethacin administration showed significant ulceration in the glandular area of their stomachs compared to normal control rats. In addition, significant elevations S.GPT, S.GOT, S. creatinine and S. Urea (P< 0.05) were observed. Alternatively, pretreatment with pomegranate and ginger significantly corrected macroscopic and biochemical parameters. These results demonstrate that administration of either pomegranate and ginger supplementation have an essential role in the prevention of ulceration induced by NSAIDs. Furthermore improved liver and kidney functions and reduced hepatoto and nephrotoxicities.https://sjuoz.uoz.edu.krd/index.php/sjuoz/article/view/461Peptic ulcerGingerindomethacinhepatic and renal functionsrats |
| spellingShingle | Mudhir S. Shekha Muhsin J. Abdulwahid Peshraw S. Hamadamin Trifa F. Ismail Saman R. Hamad Bakir Laween M. Ibrahim Lana M. Ahmed Curative Effects of Pomegranate and Ginger on Hepatic and Renal Functions of Indomethacin-Induced Peptic Ulcers in Albino Rats Science Journal of University of Zakho Peptic ulcer Ginger indomethacin hepatic and renal functions rats |
| title | Curative Effects of Pomegranate and Ginger on Hepatic and Renal Functions of Indomethacin-Induced Peptic Ulcers in Albino Rats |
| title_full | Curative Effects of Pomegranate and Ginger on Hepatic and Renal Functions of Indomethacin-Induced Peptic Ulcers in Albino Rats |
| title_fullStr | Curative Effects of Pomegranate and Ginger on Hepatic and Renal Functions of Indomethacin-Induced Peptic Ulcers in Albino Rats |
| title_full_unstemmed | Curative Effects of Pomegranate and Ginger on Hepatic and Renal Functions of Indomethacin-Induced Peptic Ulcers in Albino Rats |
| title_short | Curative Effects of Pomegranate and Ginger on Hepatic and Renal Functions of Indomethacin-Induced Peptic Ulcers in Albino Rats |
| title_sort | curative effects of pomegranate and ginger on hepatic and renal functions of indomethacin induced peptic ulcers in albino rats |
| topic | Peptic ulcer Ginger indomethacin hepatic and renal functions rats |
| url | https://sjuoz.uoz.edu.krd/index.php/sjuoz/article/view/461 |
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