Exploring the Diverse Morphology of Porous Poly(Lactic Acid) Fibers for Developing Long-Term Controlled Antibiotic Delivery Systems
In this study, we aimed to explore the morphologies of porous poly(lactic acid) (PLA) fibers through liquid–liquid phase separation, and investigate the relationship among pore formation, physical properties, and antibacterial activities of the fibers for identifying their potential as drug delivery...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-06-01
|
| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/14/6/1272 |
| _version_ | 1797483294919491584 |
|---|---|
| author | Kwon Ho Seo Kyung Eun Lee Meltem Yanilmaz Juran Kim |
| author_facet | Kwon Ho Seo Kyung Eun Lee Meltem Yanilmaz Juran Kim |
| author_sort | Kwon Ho Seo |
| collection | DOAJ |
| description | In this study, we aimed to explore the morphologies of porous poly(lactic acid) (PLA) fibers through liquid–liquid phase separation, and investigate the relationship among pore formation, physical properties, and antibacterial activities of the fibers for identifying their potential as drug delivery carriers. Antibacterial activities of gentamicin-, kanamycin-, and amikacin-loaded PLA fibers against <i>E. coli</i> and <i>S. epidermidis</i> were evaluated. The antibacterial activity of drugs against <i>E. coli</i> showed the following profile: gentamicin > amikacin > kanamycin; however, <i>S. epidermidis</i> growth was almost completely inhibited immediately after the administration of all three drugs. The efficiency of gentamicin can be attributed to the electrostatic interactions between the positively and negatively charged antibiotic and bacterial cell membrane, respectively. Furthermore, gentamicin-loaded porous PLA fibers were evaluated as drug delivery systems. The cumulative amount of gentamicin in porous PLA nanofibers was considerably higher than that in other PLA fibers for 168 h, followed by 7:3 PLA > 6:4 PLA > 5:5 PLA > non-porous PLA. The 7:3 PLA fibers were projected to be ideal drug carrier candidates for controlled antibiotic release in delivery systems owing to their interconnected internal structure and the largest surface area (55.61 m<sup>2</sup> g<sup>−1</sup>), pore size (42.19 nm), and pore volume (12.78 cm<sup>3</sup> g<sup>−1</sup>). |
| first_indexed | 2024-03-09T22:44:57Z |
| format | Article |
| id | doaj.art-d866841ef94544f99283c39bf4b9e5b4 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T22:44:57Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-d866841ef94544f99283c39bf4b9e5b42023-11-23T18:31:03ZengMDPI AGPharmaceutics1999-49232022-06-01146127210.3390/pharmaceutics14061272Exploring the Diverse Morphology of Porous Poly(Lactic Acid) Fibers for Developing Long-Term Controlled Antibiotic Delivery SystemsKwon Ho Seo0Kyung Eun Lee1Meltem Yanilmaz2Juran Kim3Advanced Textile R&D Department, Korea Institute of Industrial Technology (KITECH), Ansan 15588, KoreaDepartment of Mechanical Engineering, Inha University, 100 Inharo, Incheon 22212, KoreaDepartment of Textile Engineering, Istanbul Technical University, Istanbul 34467, TurkeyAdvanced Textile R&D Department, Korea Institute of Industrial Technology (KITECH), Ansan 15588, KoreaIn this study, we aimed to explore the morphologies of porous poly(lactic acid) (PLA) fibers through liquid–liquid phase separation, and investigate the relationship among pore formation, physical properties, and antibacterial activities of the fibers for identifying their potential as drug delivery carriers. Antibacterial activities of gentamicin-, kanamycin-, and amikacin-loaded PLA fibers against <i>E. coli</i> and <i>S. epidermidis</i> were evaluated. The antibacterial activity of drugs against <i>E. coli</i> showed the following profile: gentamicin > amikacin > kanamycin; however, <i>S. epidermidis</i> growth was almost completely inhibited immediately after the administration of all three drugs. The efficiency of gentamicin can be attributed to the electrostatic interactions between the positively and negatively charged antibiotic and bacterial cell membrane, respectively. Furthermore, gentamicin-loaded porous PLA fibers were evaluated as drug delivery systems. The cumulative amount of gentamicin in porous PLA nanofibers was considerably higher than that in other PLA fibers for 168 h, followed by 7:3 PLA > 6:4 PLA > 5:5 PLA > non-porous PLA. The 7:3 PLA fibers were projected to be ideal drug carrier candidates for controlled antibiotic release in delivery systems owing to their interconnected internal structure and the largest surface area (55.61 m<sup>2</sup> g<sup>−1</sup>), pore size (42.19 nm), and pore volume (12.78 cm<sup>3</sup> g<sup>−1</sup>).https://www.mdpi.com/1999-4923/14/6/1272antibacterial assayporous poly(lactic acid) fiberssolvent-polymer systemaminoglycoside derivativescontrolled drug releasedrug delivery |
| spellingShingle | Kwon Ho Seo Kyung Eun Lee Meltem Yanilmaz Juran Kim Exploring the Diverse Morphology of Porous Poly(Lactic Acid) Fibers for Developing Long-Term Controlled Antibiotic Delivery Systems Pharmaceutics antibacterial assay porous poly(lactic acid) fibers solvent-polymer system aminoglycoside derivatives controlled drug release drug delivery |
| title | Exploring the Diverse Morphology of Porous Poly(Lactic Acid) Fibers for Developing Long-Term Controlled Antibiotic Delivery Systems |
| title_full | Exploring the Diverse Morphology of Porous Poly(Lactic Acid) Fibers for Developing Long-Term Controlled Antibiotic Delivery Systems |
| title_fullStr | Exploring the Diverse Morphology of Porous Poly(Lactic Acid) Fibers for Developing Long-Term Controlled Antibiotic Delivery Systems |
| title_full_unstemmed | Exploring the Diverse Morphology of Porous Poly(Lactic Acid) Fibers for Developing Long-Term Controlled Antibiotic Delivery Systems |
| title_short | Exploring the Diverse Morphology of Porous Poly(Lactic Acid) Fibers for Developing Long-Term Controlled Antibiotic Delivery Systems |
| title_sort | exploring the diverse morphology of porous poly lactic acid fibers for developing long term controlled antibiotic delivery systems |
| topic | antibacterial assay porous poly(lactic acid) fibers solvent-polymer system aminoglycoside derivatives controlled drug release drug delivery |
| url | https://www.mdpi.com/1999-4923/14/6/1272 |
| work_keys_str_mv | AT kwonhoseo exploringthediversemorphologyofporouspolylacticacidfibersfordevelopinglongtermcontrolledantibioticdeliverysystems AT kyungeunlee exploringthediversemorphologyofporouspolylacticacidfibersfordevelopinglongtermcontrolledantibioticdeliverysystems AT meltemyanilmaz exploringthediversemorphologyofporouspolylacticacidfibersfordevelopinglongtermcontrolledantibioticdeliverysystems AT jurankim exploringthediversemorphologyofporouspolylacticacidfibersfordevelopinglongtermcontrolledantibioticdeliverysystems |