Pellagra: A forgotten entity
Background: Pellagra is due to deficiency of niacin or its precursor tryptophan and is characterized by four Ds: The Dermatitis, Dementia, Diarrhea, and eventually Death if it is untreated. Not long ago, the disease was endemic in several parts of the world; including India. Over the past two decade...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2019-01-01
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| Series: | Clinical Dermatology Review |
| Subjects: | |
| Online Access: | http://www.cdriadvlkn.org/article.asp?issn=2542-551X;year=2019;volume=3;issue=2;spage=126;epage=129;aulast=Brahmaiah |
| _version_ | 1818891064168153088 |
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| author | Upputuri Brahmaiah Amruth Rao Parveda R Hemalatha Avula Laxmaiah |
| author_facet | Upputuri Brahmaiah Amruth Rao Parveda R Hemalatha Avula Laxmaiah |
| author_sort | Upputuri Brahmaiah |
| collection | DOAJ |
| description | Background: Pellagra is due to deficiency of niacin or its precursor tryptophan and is characterized by four Ds: The Dermatitis, Dementia, Diarrhea, and eventually Death if it is untreated. Not long ago, the disease was endemic in several parts of the world; including India. Over the past two decades, only a few pellagra cases have been reported. By the year 2011, Pellagra had almost disappeared due to public distribution system but, the clinical features still prevail in the Indian subcontinent to some extent. Objective: The study was carried out to report our experience with pellagra in a tertiary care hospital. Materials and Methods: We undertook a retrospective study of 335 clinically diagnosed pellagra cases attending the Nutrition Unit of tertiary care hospital from 1992 to 2012. Results: In a total of 335 patients of pellagra studied, there were 316 males and 17 females. Majority of patients were in 30–40 years with mean age 42.76 ± 11.6 years. Chronic energy deficiency was seen in 63.8% of patients. Chronic alcoholism and tuberculosis were noted in 3.88% and 1.19% of patients, respectively. Conclusion: Pellagra is a complex and multisystem disease that occurs due to varied etiological factors. Of these, inadequate diet is the best-recognized cause in the developing countries like India. This study clearly recommends that general ration should be regularly distributed, especially in areas where maize and sorghum are cultivated and consumed. |
| first_indexed | 2024-12-19T17:34:52Z |
| format | Article |
| id | doaj.art-d866ad6aeddd4d2db783093f28c45234 |
| institution | Directory Open Access Journal |
| issn | 2542-551X 2542-5528 |
| language | English |
| last_indexed | 2024-12-19T17:34:52Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Clinical Dermatology Review |
| spelling | doaj.art-d866ad6aeddd4d2db783093f28c452342022-12-21T20:12:21ZengWolters Kluwer Medknow PublicationsClinical Dermatology Review2542-551X2542-55282019-01-013212612910.4103/CDR.CDR_23_18Pellagra: A forgotten entityUpputuri BrahmaiahAmruth Rao ParvedaR HemalathaAvula LaxmaiahBackground: Pellagra is due to deficiency of niacin or its precursor tryptophan and is characterized by four Ds: The Dermatitis, Dementia, Diarrhea, and eventually Death if it is untreated. Not long ago, the disease was endemic in several parts of the world; including India. Over the past two decades, only a few pellagra cases have been reported. By the year 2011, Pellagra had almost disappeared due to public distribution system but, the clinical features still prevail in the Indian subcontinent to some extent. Objective: The study was carried out to report our experience with pellagra in a tertiary care hospital. Materials and Methods: We undertook a retrospective study of 335 clinically diagnosed pellagra cases attending the Nutrition Unit of tertiary care hospital from 1992 to 2012. Results: In a total of 335 patients of pellagra studied, there were 316 males and 17 females. Majority of patients were in 30–40 years with mean age 42.76 ± 11.6 years. Chronic energy deficiency was seen in 63.8% of patients. Chronic alcoholism and tuberculosis were noted in 3.88% and 1.19% of patients, respectively. Conclusion: Pellagra is a complex and multisystem disease that occurs due to varied etiological factors. Of these, inadequate diet is the best-recognized cause in the developing countries like India. This study clearly recommends that general ration should be regularly distributed, especially in areas where maize and sorghum are cultivated and consumed.http://www.cdriadvlkn.org/article.asp?issn=2542-551X;year=2019;volume=3;issue=2;spage=126;epage=129;aulast=Brahmaiahdermatitisisoniazidniacinpellagra |
| spellingShingle | Upputuri Brahmaiah Amruth Rao Parveda R Hemalatha Avula Laxmaiah Pellagra: A forgotten entity Clinical Dermatology Review dermatitis isoniazid niacin pellagra |
| title | Pellagra: A forgotten entity |
| title_full | Pellagra: A forgotten entity |
| title_fullStr | Pellagra: A forgotten entity |
| title_full_unstemmed | Pellagra: A forgotten entity |
| title_short | Pellagra: A forgotten entity |
| title_sort | pellagra a forgotten entity |
| topic | dermatitis isoniazid niacin pellagra |
| url | http://www.cdriadvlkn.org/article.asp?issn=2542-551X;year=2019;volume=3;issue=2;spage=126;epage=129;aulast=Brahmaiah |
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