Study on Adequacy of Sample for Histopathology of Intracranial Lesions Taken from Frame Based and Frameless Navigation Guided Biopsy
Introduction: Neuronavigation guided biopsy (Frameless and Framebased stereotactic) is a simplified procedure which helps the neurosurgeons to precisely obtain the biopsy of intracranial lesions to establish the complex histopathological diagnosis.These procedures are commonly performed at our cent...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Karnali Academy of Health Sciences
2022-08-01
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| Series: | Journal of Karnali Academy of Health Sciences |
| Subjects: | |
| Online Access: | http://jkahs.org.np/jkahs/index.php/jkahs/article/view/594 |
| Summary: | Introduction: Neuronavigation guided biopsy (Frameless and Framebased stereotactic) is a simplified procedure which helps the neurosurgeons to precisely obtain the biopsy of intracranial lesions to establish the complex histopathological diagnosis.These procedures are commonly performed at our centre. The small tissue sample acquired when viewed against the vast heterogenicity of lesions and the rapidly progressive nature of few tumours make the adequacy of sample, an important parameter in determining the effectiveness of the procedure, which also has profound financial and disease related impact on the patients’ life. The objective of this study was to determine the rate of adequate sample for histopathological examination from intracranial lesions.
Methods: A prospective observational study was done in 49 patients who underwent frameless and framebased biopsies at National Neurological Referral Centre,Bir Hospital in one year.
Results: A total of 36 (73.5%) patients underwent frameless biopsy and 13(23.5%) patients underwent frame based stereotactic biopsy of intracranial lesions.Overall diagnostic yield was 89.8% with Frameless procedure giving histopathological diagnostic yield of 91.66% and framebased procedure had diagnostic yield of 84.61%.Hematoma occurred in 2 patients and seizure occurred in one patient. Majority of histopathological diagnosis was Glioblastoma(44.9%).
Conclusion: Neuronavigation guided biopsy sample of intracranial lesions obtained for histopathological diagnosis is adequate in establishing the final histopathological diagnosis which helps in enhancing patient management and outcome.
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| ISSN: | 2616-0064 2676-1327 |