Granisetron was more Effective than Ondansetron as Antiemetic in Ovarian Cancer Patients: a Randomized Controlled Trial
Objective: To determine the effectiveness of intravenous injection of granisetron compared to ondansetron in preventing nausea and vomiting, we used the MASCC Antiemesis Tool (MAT) in ovarian cancer patients undergoing paclitaxel-carboplatin chemotherapy Methods: This study was conducted as a double...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Indonesian Society of Obstetrics and Gynecology
2023-07-01
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| Series: | Indonesian Journal of Obstetrics and Gynecology |
| Online Access: | https://inajog.com/index.php/journal/article/view/1877 |
| _version_ | 1797731049150611456 |
|---|---|
| author | Hanif Reza Shinta Prawitasari Ardhanu Kusumanto |
| author_facet | Hanif Reza Shinta Prawitasari Ardhanu Kusumanto |
| author_sort | Hanif Reza |
| collection | DOAJ |
| description | Objective: To determine the effectiveness of intravenous
injection of granisetron compared to ondansetron in
preventing nausea and vomiting, we used the MASCC
Antiemesis Tool (MAT) in ovarian cancer patients undergoing
paclitaxel-carboplatin chemotherapy
Methods: This study was conducted as a double-blind,
randomized controlled trial. The treatment group received
1 mg of granisetron, whereas the control group received
8 mg of ondansetron intravenously. Nausea and vomiting
were assessed using the MAT scale at 12 hours, 24 hours,
and 48 hours after chemotherapy. The differences in MAT
scores between the groups were analyzed using the Mann-
Whitney test.
Results: A total of 60 participants were enrolled in this
study. The results indicated that the MAT score at the 12-
hour mark significantly differed from the 24-hour and 48-
hour MAT scores (p = 0.00, p = 0.00). The MAT scores in the
granisetron group at 12 hours, 24 hours, and 48 hours were
statistically lower compared to the ondansetron group (p =
0.00, p = 0.00, p = 0.00).
Conclusions: In conclusion, intravenous granisetron proved
to be more effective than intravenous ondansetron in
preventing nausea and vomiting among patients with ovarian
cancer undergoing paclitaxel-carboplatin chemotherapy.
Keywords: chemotherapy, granisetron, MAT score,
ondansetron, ovarian cancer.
Abstrak
Tujuan: Mengetahui efektivitas perbandingan pemberian
injeksi intravena antara granisetron dan ondansetron
dalam mencegah mual dan muntah dengan menggunakan
MAT pada pasien dengan kanker ovarium yang mendapat
kemoterapi dengan regimen paclitaxel-carboplatin.
Metode: Penelitian ini merupakan double blind randomized
controlled trial dengan kelompok perlakuan diberikan
granisetron 1 mg dan kelompok kontrol yang diberikan
injeksi ondansetron 8mg. Kemudian dilakukan penilaian
terhadap mual dan muntah dengan menggunakan skor
MAT pada 12 jam, 24 jam, dan 48 jam setelah diberikan
kemoterapi dengan menggunakan Mann-Whitney test
karena distribusi data tidak normal.
Hasil: Total sampel pada penelitian ini adalah 60 subjek.
Hasil skor MAT pada 12 jam berbeda bermakna dengan skor
MAT 24 jam dan skor MAT 48 jam (p= 0,00, p= 0,00. Terdapat
perbedaan bermakna secara statistik pada pengaruh terapi
granisetron dan ondansetron terhadap skor MAT 12 jam, 24
jam, dan 48 jam (p= 0,00, p= 0,00, p= 0,00).
Kesimpulan: Pemberian injeksi granisetron intravena lebih
efektif mencegah mual dan muntah dengan menggunakan
MAT dibandingkan dengan injeksi ondansetron intravena
pada pasien dengan kanker ovarium yang mendapat
kemoterapi paclitaxel-carboplatin.
Kata kunci: kemoterapi, granisetron, kanker ovarium,
ondansetron, skor MAT. |
| first_indexed | 2024-03-12T11:52:43Z |
| format | Article |
| id | doaj.art-d86b31b71f884a91be2fea90ef71608d |
| institution | Directory Open Access Journal |
| issn | 2338-6401 2338-7335 |
| language | English |
| last_indexed | 2024-03-12T11:52:43Z |
| publishDate | 2023-07-01 |
| publisher | Indonesian Society of Obstetrics and Gynecology |
| record_format | Article |
| series | Indonesian Journal of Obstetrics and Gynecology |
| spelling | doaj.art-d86b31b71f884a91be2fea90ef71608d2023-08-31T05:12:25ZengIndonesian Society of Obstetrics and GynecologyIndonesian Journal of Obstetrics and Gynecology2338-64012338-73352023-07-0114815210.32771/inajog.v11i3.18771877Granisetron was more Effective than Ondansetron as Antiemetic in Ovarian Cancer Patients: a Randomized Controlled TrialHanif Reza0Shinta Prawitasari1Ardhanu Kusumanto2Department of Obstetrics and Gynecology Sultan Agung Islamic UniversityDepartment of Obstetrics and Gynaecology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr Sardjito Hospital, Yogyakarta, IndonesiaDepartment of Obstetrics and Gynaecology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr Sardjito Hospital, Yogyakarta, IndonesiaObjective: To determine the effectiveness of intravenous injection of granisetron compared to ondansetron in preventing nausea and vomiting, we used the MASCC Antiemesis Tool (MAT) in ovarian cancer patients undergoing paclitaxel-carboplatin chemotherapy Methods: This study was conducted as a double-blind, randomized controlled trial. The treatment group received 1 mg of granisetron, whereas the control group received 8 mg of ondansetron intravenously. Nausea and vomiting were assessed using the MAT scale at 12 hours, 24 hours, and 48 hours after chemotherapy. The differences in MAT scores between the groups were analyzed using the Mann- Whitney test. Results: A total of 60 participants were enrolled in this study. The results indicated that the MAT score at the 12- hour mark significantly differed from the 24-hour and 48- hour MAT scores (p = 0.00, p = 0.00). The MAT scores in the granisetron group at 12 hours, 24 hours, and 48 hours were statistically lower compared to the ondansetron group (p = 0.00, p = 0.00, p = 0.00). Conclusions: In conclusion, intravenous granisetron proved to be more effective than intravenous ondansetron in preventing nausea and vomiting among patients with ovarian cancer undergoing paclitaxel-carboplatin chemotherapy. Keywords: chemotherapy, granisetron, MAT score, ondansetron, ovarian cancer. Abstrak Tujuan: Mengetahui efektivitas perbandingan pemberian injeksi intravena antara granisetron dan ondansetron dalam mencegah mual dan muntah dengan menggunakan MAT pada pasien dengan kanker ovarium yang mendapat kemoterapi dengan regimen paclitaxel-carboplatin. Metode: Penelitian ini merupakan double blind randomized controlled trial dengan kelompok perlakuan diberikan granisetron 1 mg dan kelompok kontrol yang diberikan injeksi ondansetron 8mg. Kemudian dilakukan penilaian terhadap mual dan muntah dengan menggunakan skor MAT pada 12 jam, 24 jam, dan 48 jam setelah diberikan kemoterapi dengan menggunakan Mann-Whitney test karena distribusi data tidak normal. Hasil: Total sampel pada penelitian ini adalah 60 subjek. Hasil skor MAT pada 12 jam berbeda bermakna dengan skor MAT 24 jam dan skor MAT 48 jam (p= 0,00, p= 0,00. Terdapat perbedaan bermakna secara statistik pada pengaruh terapi granisetron dan ondansetron terhadap skor MAT 12 jam, 24 jam, dan 48 jam (p= 0,00, p= 0,00, p= 0,00). Kesimpulan: Pemberian injeksi granisetron intravena lebih efektif mencegah mual dan muntah dengan menggunakan MAT dibandingkan dengan injeksi ondansetron intravena pada pasien dengan kanker ovarium yang mendapat kemoterapi paclitaxel-carboplatin. Kata kunci: kemoterapi, granisetron, kanker ovarium, ondansetron, skor MAT.https://inajog.com/index.php/journal/article/view/1877 |
| spellingShingle | Hanif Reza Shinta Prawitasari Ardhanu Kusumanto Granisetron was more Effective than Ondansetron as Antiemetic in Ovarian Cancer Patients: a Randomized Controlled Trial Indonesian Journal of Obstetrics and Gynecology |
| title | Granisetron was more Effective than Ondansetron as Antiemetic in Ovarian Cancer Patients: a Randomized Controlled Trial |
| title_full | Granisetron was more Effective than Ondansetron as Antiemetic in Ovarian Cancer Patients: a Randomized Controlled Trial |
| title_fullStr | Granisetron was more Effective than Ondansetron as Antiemetic in Ovarian Cancer Patients: a Randomized Controlled Trial |
| title_full_unstemmed | Granisetron was more Effective than Ondansetron as Antiemetic in Ovarian Cancer Patients: a Randomized Controlled Trial |
| title_short | Granisetron was more Effective than Ondansetron as Antiemetic in Ovarian Cancer Patients: a Randomized Controlled Trial |
| title_sort | granisetron was more effective than ondansetron as antiemetic in ovarian cancer patients a randomized controlled trial |
| url | https://inajog.com/index.php/journal/article/view/1877 |
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