Antibacterial Activity of Some 3-(Arylideneamino)-2-phenylquinazoline-4(3H)-ones: Synthesis and Preliminary QSAR Studies
Synthesis of ten 3-(arylideneamino)-2-phenylquinazoline-4(3H)-ones is reported. All the compounds contained a common phenyl group at the 2-position, while the substituents on the arylideneamino group were varied. The compounds were investigated for their antimicrobial activity against both Gram-posi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2007-10-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/12/10/2413/ |
| _version_ | 1818205645846872064 |
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| author | Ranadhir Chakraborty Subarna Ganguli Ashis Kumar Nanda |
| author_facet | Ranadhir Chakraborty Subarna Ganguli Ashis Kumar Nanda |
| author_sort | Ranadhir Chakraborty |
| collection | DOAJ |
| description | Synthesis of ten 3-(arylideneamino)-2-phenylquinazoline-4(3H)-ones is reported. All the compounds contained a common phenyl group at the 2-position, while the substituents on the arylideneamino group were varied. The compounds were investigated for their antimicrobial activity against both Gram-positive (Staphylococcus aureus 6571 and Bacillus subtilis) and Gram-negative bacteria (Escherichia coli K12 and Shigella dysenteriae 6) using a turbidometric assay method. It was found that the incorporation of the 3-arylideneamino substituent enhanced the anti-bacterial activity of the quinazolone system. The preliminary QSAR studies were done using some computer derived property descriptors, calculated values of partition coefficients as well as usual Hammett’s sigma constants and the substituent’s molar refractivity. |
| first_indexed | 2024-12-12T04:00:26Z |
| format | Article |
| id | doaj.art-d86b6a055f094bc6b9053edb1dd9db90 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-12T04:00:26Z |
| publishDate | 2007-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-d86b6a055f094bc6b9053edb1dd9db902022-12-22T00:39:05ZengMDPI AGMolecules1420-30492007-10-0112102413242610.3390/12102413Antibacterial Activity of Some 3-(Arylideneamino)-2-phenylquinazoline-4(3H)-ones: Synthesis and Preliminary QSAR StudiesRanadhir ChakrabortySubarna GanguliAshis Kumar NandaSynthesis of ten 3-(arylideneamino)-2-phenylquinazoline-4(3H)-ones is reported. All the compounds contained a common phenyl group at the 2-position, while the substituents on the arylideneamino group were varied. The compounds were investigated for their antimicrobial activity against both Gram-positive (Staphylococcus aureus 6571 and Bacillus subtilis) and Gram-negative bacteria (Escherichia coli K12 and Shigella dysenteriae 6) using a turbidometric assay method. It was found that the incorporation of the 3-arylideneamino substituent enhanced the anti-bacterial activity of the quinazolone system. The preliminary QSAR studies were done using some computer derived property descriptors, calculated values of partition coefficients as well as usual Hammett’s sigma constants and the substituent’s molar refractivity.http://www.mdpi.com/1420-3049/12/10/2413/2-Phenylquinazoline-4(3H)-oneantibacterial activitiesQSARquinazolones. |
| spellingShingle | Ranadhir Chakraborty Subarna Ganguli Ashis Kumar Nanda Antibacterial Activity of Some 3-(Arylideneamino)-2-phenylquinazoline-4(3H)-ones: Synthesis and Preliminary QSAR Studies Molecules 2-Phenylquinazoline-4(3H)-one antibacterial activities QSAR quinazolones. |
| title | Antibacterial Activity of Some 3-(Arylideneamino)-2-phenylquinazoline-4(3H)-ones: Synthesis and Preliminary QSAR Studies |
| title_full | Antibacterial Activity of Some 3-(Arylideneamino)-2-phenylquinazoline-4(3H)-ones: Synthesis and Preliminary QSAR Studies |
| title_fullStr | Antibacterial Activity of Some 3-(Arylideneamino)-2-phenylquinazoline-4(3H)-ones: Synthesis and Preliminary QSAR Studies |
| title_full_unstemmed | Antibacterial Activity of Some 3-(Arylideneamino)-2-phenylquinazoline-4(3H)-ones: Synthesis and Preliminary QSAR Studies |
| title_short | Antibacterial Activity of Some 3-(Arylideneamino)-2-phenylquinazoline-4(3H)-ones: Synthesis and Preliminary QSAR Studies |
| title_sort | antibacterial activity of some 3 arylideneamino 2 phenylquinazoline 4 3h ones synthesis and preliminary qsar studies |
| topic | 2-Phenylquinazoline-4(3H)-one antibacterial activities QSAR quinazolones. |
| url | http://www.mdpi.com/1420-3049/12/10/2413/ |
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