AGR2 and FOXA1 as prognostic markers in ER-positive breast cancer
Abstract Background The prognostic role of either forkhead box A1 (FOXA1) or anterior gradient 2 (AGR2) in breast cancer has been found separately. Considering that there were interplays between them depending on ER status, we aimed to assess the statistical interaction between AGR2 and FOXA1 on bre...
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-023-10964-6 |
| _version_ | 1797559051256594432 |
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| author | Meng Zhou Xing-li Gan Yue-xiang Ren Qian-xin Chen Yuan-zhong Yang Zi-jin Weng Xiao-fang Zhang Jie-xia Guan Lu-ying Tang Ze-fang Ren |
| author_facet | Meng Zhou Xing-li Gan Yue-xiang Ren Qian-xin Chen Yuan-zhong Yang Zi-jin Weng Xiao-fang Zhang Jie-xia Guan Lu-ying Tang Ze-fang Ren |
| author_sort | Meng Zhou |
| collection | DOAJ |
| description | Abstract Background The prognostic role of either forkhead box A1 (FOXA1) or anterior gradient 2 (AGR2) in breast cancer has been found separately. Considering that there were interplays between them depending on ER status, we aimed to assess the statistical interaction between AGR2 and FOXA1 on breast cancer prognosis and examine the prognostic role of the combination of them by ER status. Methods AGR2 and FOXA1 expression in tumor tissues were evaluated with tissue microarrays by immunohistochemistry in 915 breast cancer patients with follow up data. The expression levels of these two markers were treated as binary variables, and many different cutoff values were tried for each marker. Survival and Cox proportional hazard analyses were used to evaluate the relationship between AGR2, FOXA1 and prognosis, and the statistical interaction between them on the prognosis was assessed on multiplicative scale. Results Statistical interaction between AGR2 and FOXA1 on the PFS was significant with all the cutoff points in ER-positive breast cancer patients but not ER-negative ones. Among ER-positive patients, the poor prognostic role of the high level of FOXA1 was significant only in patients with the low level of AGR2, and vice versa. When AGR2 and FOXA1 were considered together, patients with low levels of both markers had significantly longer PFS compared with all other groups. Conclusions There was a statistical interaction between AGR2 and FOXA1 on the prognosis of ER-positive breast cancer. The combination of AGR2 and FOXA1 was a more useful marker for the prognosis of ER-positive breast cancer patients. |
| first_indexed | 2024-03-10T17:40:14Z |
| format | Article |
| id | doaj.art-d86d0ca8b1ca4c66ae4f2beb866cd157 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-03-10T17:40:14Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-d86d0ca8b1ca4c66ae4f2beb866cd1572023-11-20T09:44:10ZengBMCBMC Cancer1471-24072023-08-0123111110.1186/s12885-023-10964-6AGR2 and FOXA1 as prognostic markers in ER-positive breast cancerMeng Zhou0Xing-li Gan1Yue-xiang Ren2Qian-xin Chen3Yuan-zhong Yang4Zi-jin Weng5Xiao-fang Zhang6Jie-xia Guan7Lu-ying Tang8Ze-fang Ren9School of Public Health, Sun Yat-Sen UniversitySchool of Public Health, Sun Yat-Sen UniversityThe Third Affiliated Hospital, Sun Yat-Sen UniversitySchool of Public Health, Sun Yat-Sen UniversityThe Sun Yat-sen University Cancer CenterThe Third Affiliated Hospital, Sun Yat-Sen UniversityThe Third Affiliated Hospital, Sun Yat-Sen UniversityThe Third Affiliated Hospital, Sun Yat-Sen UniversityThe Third Affiliated Hospital, Sun Yat-Sen UniversitySchool of Public Health, Sun Yat-Sen UniversityAbstract Background The prognostic role of either forkhead box A1 (FOXA1) or anterior gradient 2 (AGR2) in breast cancer has been found separately. Considering that there were interplays between them depending on ER status, we aimed to assess the statistical interaction between AGR2 and FOXA1 on breast cancer prognosis and examine the prognostic role of the combination of them by ER status. Methods AGR2 and FOXA1 expression in tumor tissues were evaluated with tissue microarrays by immunohistochemistry in 915 breast cancer patients with follow up data. The expression levels of these two markers were treated as binary variables, and many different cutoff values were tried for each marker. Survival and Cox proportional hazard analyses were used to evaluate the relationship between AGR2, FOXA1 and prognosis, and the statistical interaction between them on the prognosis was assessed on multiplicative scale. Results Statistical interaction between AGR2 and FOXA1 on the PFS was significant with all the cutoff points in ER-positive breast cancer patients but not ER-negative ones. Among ER-positive patients, the poor prognostic role of the high level of FOXA1 was significant only in patients with the low level of AGR2, and vice versa. When AGR2 and FOXA1 were considered together, patients with low levels of both markers had significantly longer PFS compared with all other groups. Conclusions There was a statistical interaction between AGR2 and FOXA1 on the prognosis of ER-positive breast cancer. The combination of AGR2 and FOXA1 was a more useful marker for the prognosis of ER-positive breast cancer patients.https://doi.org/10.1186/s12885-023-10964-6Breast cancerPrognosisAGR2FOXA1 |
| spellingShingle | Meng Zhou Xing-li Gan Yue-xiang Ren Qian-xin Chen Yuan-zhong Yang Zi-jin Weng Xiao-fang Zhang Jie-xia Guan Lu-ying Tang Ze-fang Ren AGR2 and FOXA1 as prognostic markers in ER-positive breast cancer BMC Cancer Breast cancer Prognosis AGR2 FOXA1 |
| title | AGR2 and FOXA1 as prognostic markers in ER-positive breast cancer |
| title_full | AGR2 and FOXA1 as prognostic markers in ER-positive breast cancer |
| title_fullStr | AGR2 and FOXA1 as prognostic markers in ER-positive breast cancer |
| title_full_unstemmed | AGR2 and FOXA1 as prognostic markers in ER-positive breast cancer |
| title_short | AGR2 and FOXA1 as prognostic markers in ER-positive breast cancer |
| title_sort | agr2 and foxa1 as prognostic markers in er positive breast cancer |
| topic | Breast cancer Prognosis AGR2 FOXA1 |
| url | https://doi.org/10.1186/s12885-023-10964-6 |
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