Clinical significance of red blood cell distribution width in the prediction of mortality in patients on peritoneal dialysis
Background: In this study, we assessed whether red blood cell distribution width (RDW) was associated with all-cause mortality in patients on peritoneal dialysis (PD) and evaluated its prognostic value. Methods: This study included 136 patients who had RDW levels at PD initiation from January 2007 t...
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| Format: | Article |
| Language: | English |
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The Korean Society of Nephrology
2016-06-01
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| Series: | Kidney Research and Clinical Practice |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211913215300929 |
| _version_ | 1819130739190398976 |
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| author | In O. Sun Byung Ha Chung Hyun Ju Yoon Jeong Ho Kim Bum Soon Choi Cheol Whee Park Yong Soo Kim Chul Woo Yang Kwang Young Lee |
| author_facet | In O. Sun Byung Ha Chung Hyun Ju Yoon Jeong Ho Kim Bum Soon Choi Cheol Whee Park Yong Soo Kim Chul Woo Yang Kwang Young Lee |
| author_sort | In O. Sun |
| collection | DOAJ |
| description | Background: In this study, we assessed whether red blood cell distribution width (RDW) was associated with all-cause mortality in patients on peritoneal dialysis (PD) and evaluated its prognostic value.
Methods: This study included 136 patients who had RDW levels at PD initiation from January 2007 to January 2014 at the Presbyterian Medical Center and Seoul St. Mary's Hospital. We divided these patients into 2 groups (survivors vs. nonsurvivors), compared their clinical characteristics, and analyzed the predictors of survival.
Results: The study included 79 men and 57 women, with a mean age of 54 years (range, 15–85 years). The mean follow-up duration was 32 months (range, 1–80 months). Of 136 patients, 14 died during the follow-up period. When clinical characteristics of survivors (n = 122) and nonsurvivors (n = 14) were compared, no differences were identified, with the exception of serum albumin, total iron-binding capacity (TIBC), left ventricular ejection fraction, total leukocyte count, and RDW value. Survivors had higher serum albumin (3.4 ± 0.5 vs. 3.0 ± 0.5 g/dL, P < 0.001) and left ventricular ejection fraction (56.8 ± 9.8 vs. 48.7 ± 12.8, P = 0.040) and lower TIBC (213.4 ± 40.9 vs. 252.8 ± 65.6, P = 0.010), total leukocyte counts (6.9 × 103/μL vs. 8.6 × 103/μL, P = 0.009), and serum RDW values (13.9 ± 1.7 vs. 16.0 ± 1.8, P < 0.001). Patients with high RDW levels (≥ 14.8) showed significantly higher all-cause mortality than patients with low RDW levels (< 14.8, P < 0.001). In multivariate-adjusted Cox analysis, RDW and TIBC at the start of PD were independent risk predictors for all-cause mortality.
Conclusion: RDW could be an additive predictor for all-cause mortality in patients on PD. |
| first_indexed | 2024-12-22T09:04:24Z |
| format | Article |
| id | doaj.art-d86f1742ba6243f39c7859431ffae7eb |
| institution | Directory Open Access Journal |
| issn | 2211-9132 |
| language | English |
| last_indexed | 2024-12-22T09:04:24Z |
| publishDate | 2016-06-01 |
| publisher | The Korean Society of Nephrology |
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| series | Kidney Research and Clinical Practice |
| spelling | doaj.art-d86f1742ba6243f39c7859431ffae7eb2022-12-21T18:31:39ZengThe Korean Society of NephrologyKidney Research and Clinical Practice2211-91322016-06-0135211411810.1016/j.krcp.2016.03.003Clinical significance of red blood cell distribution width in the prediction of mortality in patients on peritoneal dialysisIn O. Sun0Byung Ha Chung1Hyun Ju Yoon2Jeong Ho Kim3Bum Soon Choi4Cheol Whee Park5Yong Soo Kim6Chul Woo Yang7Kwang Young Lee8Nephrology Division, Department of Internal Medicine, Presbyterian Medical Center, Jeonju, KoreaDivision of Nephrology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, KoreaNephrology Division, Department of Internal Medicine, Presbyterian Medical Center, Jeonju, KoreaDivision of Nephrology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, KoreaDivision of Nephrology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, KoreaDivision of Nephrology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, KoreaDivision of Nephrology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, KoreaDivision of Nephrology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, KoreaNephrology Division, Department of Internal Medicine, Presbyterian Medical Center, Jeonju, KoreaBackground: In this study, we assessed whether red blood cell distribution width (RDW) was associated with all-cause mortality in patients on peritoneal dialysis (PD) and evaluated its prognostic value. Methods: This study included 136 patients who had RDW levels at PD initiation from January 2007 to January 2014 at the Presbyterian Medical Center and Seoul St. Mary's Hospital. We divided these patients into 2 groups (survivors vs. nonsurvivors), compared their clinical characteristics, and analyzed the predictors of survival. Results: The study included 79 men and 57 women, with a mean age of 54 years (range, 15–85 years). The mean follow-up duration was 32 months (range, 1–80 months). Of 136 patients, 14 died during the follow-up period. When clinical characteristics of survivors (n = 122) and nonsurvivors (n = 14) were compared, no differences were identified, with the exception of serum albumin, total iron-binding capacity (TIBC), left ventricular ejection fraction, total leukocyte count, and RDW value. Survivors had higher serum albumin (3.4 ± 0.5 vs. 3.0 ± 0.5 g/dL, P < 0.001) and left ventricular ejection fraction (56.8 ± 9.8 vs. 48.7 ± 12.8, P = 0.040) and lower TIBC (213.4 ± 40.9 vs. 252.8 ± 65.6, P = 0.010), total leukocyte counts (6.9 × 103/μL vs. 8.6 × 103/μL, P = 0.009), and serum RDW values (13.9 ± 1.7 vs. 16.0 ± 1.8, P < 0.001). Patients with high RDW levels (≥ 14.8) showed significantly higher all-cause mortality than patients with low RDW levels (< 14.8, P < 0.001). In multivariate-adjusted Cox analysis, RDW and TIBC at the start of PD were independent risk predictors for all-cause mortality. Conclusion: RDW could be an additive predictor for all-cause mortality in patients on PD.http://www.sciencedirect.com/science/article/pii/S2211913215300929Erythrocyte indicesPeritoneal dialysisRed blood cell distribution width |
| spellingShingle | In O. Sun Byung Ha Chung Hyun Ju Yoon Jeong Ho Kim Bum Soon Choi Cheol Whee Park Yong Soo Kim Chul Woo Yang Kwang Young Lee Clinical significance of red blood cell distribution width in the prediction of mortality in patients on peritoneal dialysis Kidney Research and Clinical Practice Erythrocyte indices Peritoneal dialysis Red blood cell distribution width |
| title | Clinical significance of red blood cell distribution width in the prediction of mortality in patients on peritoneal dialysis |
| title_full | Clinical significance of red blood cell distribution width in the prediction of mortality in patients on peritoneal dialysis |
| title_fullStr | Clinical significance of red blood cell distribution width in the prediction of mortality in patients on peritoneal dialysis |
| title_full_unstemmed | Clinical significance of red blood cell distribution width in the prediction of mortality in patients on peritoneal dialysis |
| title_short | Clinical significance of red blood cell distribution width in the prediction of mortality in patients on peritoneal dialysis |
| title_sort | clinical significance of red blood cell distribution width in the prediction of mortality in patients on peritoneal dialysis |
| topic | Erythrocyte indices Peritoneal dialysis Red blood cell distribution width |
| url | http://www.sciencedirect.com/science/article/pii/S2211913215300929 |
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