Vascular and Neuronal Network Formation Regulated by Growth Factors and Guidance Cues
Blood vessels and nerves are distributed throughout the body and show a high degree of anatomical parallelism and functional crosstalk. These networks transport oxygen, nutrients, and information to maintain homeostasis. Thus, disruption of network formation can cause diseases. Nervous system develo...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/13/2/283 |
| _version_ | 1797619862043885568 |
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| author | Yuki Wakayama Satoru Yamagishi |
| author_facet | Yuki Wakayama Satoru Yamagishi |
| author_sort | Yuki Wakayama |
| collection | DOAJ |
| description | Blood vessels and nerves are distributed throughout the body and show a high degree of anatomical parallelism and functional crosstalk. These networks transport oxygen, nutrients, and information to maintain homeostasis. Thus, disruption of network formation can cause diseases. Nervous system development requires the navigation of the axons of neurons to their correct destination. Blood vessel formation occurs via vasculogenesis and angiogenesis. Vasculogenesis is the process of de novo blood vessel formation, and angiogenesis is the process whereby endothelial cells sprout from pre-existing vessels. Both developmental processes require guidance molecules to establish precise branching patterns of these systems in the vertebrate body. These network formations are regulated by growth factors, such as vascular endothelial growth factor; and guidance cues, such as ephrin, netrin, semaphorin, and slit. Neuronal and vascular structures extend lamellipodia and filopodia, which sense guidance cues that are mediated by the Rho family and actin cytosol rearrangement, to migrate to the goal during development. Furthermore, endothelial cells regulate neuronal development and vice versa. In this review, we describe the guidance molecules that regulate neuronal and vascular network formation. |
| first_indexed | 2024-03-11T08:34:02Z |
| format | Article |
| id | doaj.art-d8707f6fd8be4ebb91f0e97b5cf1ddaa |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-11T08:34:02Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-d8707f6fd8be4ebb91f0e97b5cf1ddaa2023-11-16T21:39:08ZengMDPI AGLife2075-17292023-01-0113228310.3390/life13020283Vascular and Neuronal Network Formation Regulated by Growth Factors and Guidance CuesYuki Wakayama0Satoru Yamagishi1Max Planck Institute for Molecular Biomedicine, Roentgenstrasse 20, 48149 Muenster, GermanyDepartment of Organ and Tissue Anatomy, Hamamatsu University School of Medicine, Hamamatsu 431-3192, JapanBlood vessels and nerves are distributed throughout the body and show a high degree of anatomical parallelism and functional crosstalk. These networks transport oxygen, nutrients, and information to maintain homeostasis. Thus, disruption of network formation can cause diseases. Nervous system development requires the navigation of the axons of neurons to their correct destination. Blood vessel formation occurs via vasculogenesis and angiogenesis. Vasculogenesis is the process of de novo blood vessel formation, and angiogenesis is the process whereby endothelial cells sprout from pre-existing vessels. Both developmental processes require guidance molecules to establish precise branching patterns of these systems in the vertebrate body. These network formations are regulated by growth factors, such as vascular endothelial growth factor; and guidance cues, such as ephrin, netrin, semaphorin, and slit. Neuronal and vascular structures extend lamellipodia and filopodia, which sense guidance cues that are mediated by the Rho family and actin cytosol rearrangement, to migrate to the goal during development. Furthermore, endothelial cells regulate neuronal development and vice versa. In this review, we describe the guidance molecules that regulate neuronal and vascular network formation.https://www.mdpi.com/2075-1729/13/2/283blood vessel formationneuronal formationguidance molecules |
| spellingShingle | Yuki Wakayama Satoru Yamagishi Vascular and Neuronal Network Formation Regulated by Growth Factors and Guidance Cues Life blood vessel formation neuronal formation guidance molecules |
| title | Vascular and Neuronal Network Formation Regulated by Growth Factors and Guidance Cues |
| title_full | Vascular and Neuronal Network Formation Regulated by Growth Factors and Guidance Cues |
| title_fullStr | Vascular and Neuronal Network Formation Regulated by Growth Factors and Guidance Cues |
| title_full_unstemmed | Vascular and Neuronal Network Formation Regulated by Growth Factors and Guidance Cues |
| title_short | Vascular and Neuronal Network Formation Regulated by Growth Factors and Guidance Cues |
| title_sort | vascular and neuronal network formation regulated by growth factors and guidance cues |
| topic | blood vessel formation neuronal formation guidance molecules |
| url | https://www.mdpi.com/2075-1729/13/2/283 |
| work_keys_str_mv | AT yukiwakayama vascularandneuronalnetworkformationregulatedbygrowthfactorsandguidancecues AT satoruyamagishi vascularandneuronalnetworkformationregulatedbygrowthfactorsandguidancecues |