High rate of completion for weekly rifapentine plus isoniazid treatment in Chinese children with latent tuberculosis infection-A single center study.
Three months of weekly rifapentine plus isoniazid (3HP) is a short course regimen for latent tuberculosis infection treatment with satisfied safety and efficacy. However, research on its use in children is limited. In this study, we evaluated the completion rate and safety of the 3HP regimen among c...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2021-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0253159&type=printable |
| _version_ | 1826554636768641024 |
|---|---|
| author | Heng Yang Yang Yang Zhi-Dong Hu Lu Xia Xu-Hui Liu Xin Yu Jia-Ye Ma Tao Li Shui-Hua Lu |
| author_facet | Heng Yang Yang Yang Zhi-Dong Hu Lu Xia Xu-Hui Liu Xin Yu Jia-Ye Ma Tao Li Shui-Hua Lu |
| author_sort | Heng Yang |
| collection | DOAJ |
| description | Three months of weekly rifapentine plus isoniazid (3HP) is a short course regimen for latent tuberculosis infection treatment with satisfied safety and efficacy. However, research on its use in children is limited. In this study, we evaluated the completion rate and safety of the 3HP regimen among children in China. Participants aged 1-14 years receiving 3HP for TB prevention at Shanghai Public Health Clinical Center were followed from December 2019 to November 2020 to evaluate the safety and completion rate of the treatment. Thirty-one children were eligible for inclusion, but five were excluded from the analysis (three were treated with a lower than recommended dose, and two were lost to follow-up). Of the 26 children included in the analysis, the treatment completion rate was 100%. Adverse drug reactions (ADRs) were reported in 38.5% (10/26) of the patients. The most common ADRs were gastrointestinal symptoms (19.2%,5/26), and all ADRs were rated as Grade 1. The 3HP regimen has a high completion rate, and it seems well tolerated in our study population. However, further randomized controlled clinical trial with larger sample size are warranted. |
| first_indexed | 2024-12-14T07:54:52Z |
| format | Article |
| id | doaj.art-d870e0a6b3914df782c79e3639dbd6f6 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2025-03-14T07:44:04Z |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-d870e0a6b3914df782c79e3639dbd6f62025-03-03T05:33:39ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-01166e025315910.1371/journal.pone.0253159High rate of completion for weekly rifapentine plus isoniazid treatment in Chinese children with latent tuberculosis infection-A single center study.Heng YangYang YangZhi-Dong HuLu XiaXu-Hui LiuXin YuJia-Ye MaTao LiShui-Hua LuThree months of weekly rifapentine plus isoniazid (3HP) is a short course regimen for latent tuberculosis infection treatment with satisfied safety and efficacy. However, research on its use in children is limited. In this study, we evaluated the completion rate and safety of the 3HP regimen among children in China. Participants aged 1-14 years receiving 3HP for TB prevention at Shanghai Public Health Clinical Center were followed from December 2019 to November 2020 to evaluate the safety and completion rate of the treatment. Thirty-one children were eligible for inclusion, but five were excluded from the analysis (three were treated with a lower than recommended dose, and two were lost to follow-up). Of the 26 children included in the analysis, the treatment completion rate was 100%. Adverse drug reactions (ADRs) were reported in 38.5% (10/26) of the patients. The most common ADRs were gastrointestinal symptoms (19.2%,5/26), and all ADRs were rated as Grade 1. The 3HP regimen has a high completion rate, and it seems well tolerated in our study population. However, further randomized controlled clinical trial with larger sample size are warranted.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0253159&type=printable |
| spellingShingle | Heng Yang Yang Yang Zhi-Dong Hu Lu Xia Xu-Hui Liu Xin Yu Jia-Ye Ma Tao Li Shui-Hua Lu High rate of completion for weekly rifapentine plus isoniazid treatment in Chinese children with latent tuberculosis infection-A single center study. PLoS ONE |
| title | High rate of completion for weekly rifapentine plus isoniazid treatment in Chinese children with latent tuberculosis infection-A single center study. |
| title_full | High rate of completion for weekly rifapentine plus isoniazid treatment in Chinese children with latent tuberculosis infection-A single center study. |
| title_fullStr | High rate of completion for weekly rifapentine plus isoniazid treatment in Chinese children with latent tuberculosis infection-A single center study. |
| title_full_unstemmed | High rate of completion for weekly rifapentine plus isoniazid treatment in Chinese children with latent tuberculosis infection-A single center study. |
| title_short | High rate of completion for weekly rifapentine plus isoniazid treatment in Chinese children with latent tuberculosis infection-A single center study. |
| title_sort | high rate of completion for weekly rifapentine plus isoniazid treatment in chinese children with latent tuberculosis infection a single center study |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0253159&type=printable |
| work_keys_str_mv | AT hengyang highrateofcompletionforweeklyrifapentineplusisoniazidtreatmentinchinesechildrenwithlatenttuberculosisinfectionasinglecenterstudy AT yangyang highrateofcompletionforweeklyrifapentineplusisoniazidtreatmentinchinesechildrenwithlatenttuberculosisinfectionasinglecenterstudy AT zhidonghu highrateofcompletionforweeklyrifapentineplusisoniazidtreatmentinchinesechildrenwithlatenttuberculosisinfectionasinglecenterstudy AT luxia highrateofcompletionforweeklyrifapentineplusisoniazidtreatmentinchinesechildrenwithlatenttuberculosisinfectionasinglecenterstudy AT xuhuiliu highrateofcompletionforweeklyrifapentineplusisoniazidtreatmentinchinesechildrenwithlatenttuberculosisinfectionasinglecenterstudy AT xinyu highrateofcompletionforweeklyrifapentineplusisoniazidtreatmentinchinesechildrenwithlatenttuberculosisinfectionasinglecenterstudy AT jiayema highrateofcompletionforweeklyrifapentineplusisoniazidtreatmentinchinesechildrenwithlatenttuberculosisinfectionasinglecenterstudy AT taoli highrateofcompletionforweeklyrifapentineplusisoniazidtreatmentinchinesechildrenwithlatenttuberculosisinfectionasinglecenterstudy AT shuihualu highrateofcompletionforweeklyrifapentineplusisoniazidtreatmentinchinesechildrenwithlatenttuberculosisinfectionasinglecenterstudy |