Drosulfakinin signaling modulates female sexual receptivity in Drosophila
Female sexual behavior as an innate behavior is of prominent biological importance for survival and reproduction. However, molecular and circuit mechanisms underlying female sexual behavior is not well understood. Here, we identify the Cholecystokinin-like peptide Drosulfakinin (DSK) to promote fema...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2022-04-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/76025 |
| _version_ | 1797998271027740672 |
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| author | Tao Wang Biyang Jing Bowen Deng Kai Shi Jing Li Baoxu Ma Fengming Wu Chuan Zhou |
| author_facet | Tao Wang Biyang Jing Bowen Deng Kai Shi Jing Li Baoxu Ma Fengming Wu Chuan Zhou |
| author_sort | Tao Wang |
| collection | DOAJ |
| description | Female sexual behavior as an innate behavior is of prominent biological importance for survival and reproduction. However, molecular and circuit mechanisms underlying female sexual behavior is not well understood. Here, we identify the Cholecystokinin-like peptide Drosulfakinin (DSK) to promote female sexual behavior in Drosophila. Loss of DSK function reduces female receptivity while overexpressing DSK enhances female receptivity. We identify two pairs of Dsk-expressing neurons in the central brain to promote female receptivity. We find that the DSK peptide acts through one of its receptors, CCKLR-17D3, to modulate female receptivity. Manipulation of CCKLR-17D3 and its expressing neurons alters female receptivity. We further reveal that the two pairs of Dsk-expressing neurons receive input signal from pC1 neurons that integrate sex-related cues and mating status. These results demonstrate how a neuropeptide pathway interacts with a central neural node in the female sex circuitry to modulate sexual receptivity. |
| first_indexed | 2024-04-11T10:46:01Z |
| format | Article |
| id | doaj.art-d871bca06bfa4f82b4999117d5a2bfc7 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-11T10:46:01Z |
| publishDate | 2022-04-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-d871bca06bfa4f82b4999117d5a2bfc72022-12-22T04:29:04ZengeLife Sciences Publications LtdeLife2050-084X2022-04-011110.7554/eLife.76025Drosulfakinin signaling modulates female sexual receptivity in DrosophilaTao Wang0Biyang Jing1Bowen Deng2Kai Shi3Jing Li4Baoxu Ma5Fengming Wu6Chuan Zhou7https://orcid.org/0000-0001-7952-7048School of Life Sciences, University of Science and Technology of China, Hefei, China; State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of Zoology, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, ChinaState Key Laboratory of Membrane Biology, College of Life Sciences, IDG/McGovern Institute for Brain Research, Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, ChinaChinese Institute for Brain Research, Peking-Tsinghua Center for Life Sciences, Zhongguangcun Life Sciences Park, Beijing, ChinaState Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of Zoology, Chinese Academy of Sciences, Beijing, ChinaInstitute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen, ChinaState Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of Zoology, Chinese Academy of Sciences, Beijing, ChinaState Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of Zoology, Chinese Academy of Sciences, Beijing, ChinaState Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of Zoology, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China; Institute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen, ChinaFemale sexual behavior as an innate behavior is of prominent biological importance for survival and reproduction. However, molecular and circuit mechanisms underlying female sexual behavior is not well understood. Here, we identify the Cholecystokinin-like peptide Drosulfakinin (DSK) to promote female sexual behavior in Drosophila. Loss of DSK function reduces female receptivity while overexpressing DSK enhances female receptivity. We identify two pairs of Dsk-expressing neurons in the central brain to promote female receptivity. We find that the DSK peptide acts through one of its receptors, CCKLR-17D3, to modulate female receptivity. Manipulation of CCKLR-17D3 and its expressing neurons alters female receptivity. We further reveal that the two pairs of Dsk-expressing neurons receive input signal from pC1 neurons that integrate sex-related cues and mating status. These results demonstrate how a neuropeptide pathway interacts with a central neural node in the female sex circuitry to modulate sexual receptivity.https://elifesciences.org/articles/76025sexual behaviorDrosulfakininneural circuit |
| spellingShingle | Tao Wang Biyang Jing Bowen Deng Kai Shi Jing Li Baoxu Ma Fengming Wu Chuan Zhou Drosulfakinin signaling modulates female sexual receptivity in Drosophila eLife sexual behavior Drosulfakinin neural circuit |
| title | Drosulfakinin signaling modulates female sexual receptivity in Drosophila |
| title_full | Drosulfakinin signaling modulates female sexual receptivity in Drosophila |
| title_fullStr | Drosulfakinin signaling modulates female sexual receptivity in Drosophila |
| title_full_unstemmed | Drosulfakinin signaling modulates female sexual receptivity in Drosophila |
| title_short | Drosulfakinin signaling modulates female sexual receptivity in Drosophila |
| title_sort | drosulfakinin signaling modulates female sexual receptivity in drosophila |
| topic | sexual behavior Drosulfakinin neural circuit |
| url | https://elifesciences.org/articles/76025 |
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