Relationship Between 25-Hydroxyvitamin D, Renin, and Collagen Remodeling Biomarkers in Atrial Fibrillation
The interplay between vitamin D, the renin–angiotensin system (RAS), and collagen remodeling has been implicated in the pathogenesis of various cardiovascular diseases. This study sought to explore this relationship in atrial fibrillation (AF) by profiling plasma levels of 25-hydroxyvitamin D, RAS b...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2020-02-01
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| Series: | Clinical and Applied Thrombosis/Hemostasis |
| Online Access: | https://doi.org/10.1177/1076029619899702 |
| _version_ | 1819007513935216640 |
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| author | Dimpi Patel BA Aleksander Druck BS Debra Hoppensteadt PhD Vinod Bansal MD Yevgeniy Brailovsky DO Mushabbar Syed MD Jawed Fareed PhD |
| author_facet | Dimpi Patel BA Aleksander Druck BS Debra Hoppensteadt PhD Vinod Bansal MD Yevgeniy Brailovsky DO Mushabbar Syed MD Jawed Fareed PhD |
| author_sort | Dimpi Patel BA |
| collection | DOAJ |
| description | The interplay between vitamin D, the renin–angiotensin system (RAS), and collagen remodeling has been implicated in the pathogenesis of various cardiovascular diseases. This study sought to explore this relationship in atrial fibrillation (AF) by profiling plasma levels of 25-hydroxyvitamin D, RAS biomarkers, and collagen remodeling biomarkers using the enzyme-linked immunosorbent assay method. We hypothesized that 25-hydroxyvitamin D levels would inversely correlate with RAS biomarkers and that levels of RAS and collagen remodeling biomarkers would positively correlate with each other. Although our AF cohort (n = 37) did not exhibit decreased 25-hydroxyvitamin D levels compared to normal controls (n = 26), these levels inversely correlated with renin (Spearman r = −0.57, P = 0.005). Renin levels were elevated in patients with AF compared to normal controls (1233 ± 238 ng/mL vs 401 ± 27 ng/mL, P = 0.0002) and positively correlated with levels of matrix metalloproteinase 1 (MMP-1; Spearman r = 0.89, P = 0.01) and MMP-2 (Spearman r = 0.82, P = 0.03). These data suggest that 25-hydroxyvitamin D may influence RAS activation, and renin may help mediate the collagen remodeling process in AF. Understanding mediators of RAS dysregulation in AF may elucidate targets for therapeutic intervention to prevent collagen remodeling. |
| first_indexed | 2024-12-21T00:25:47Z |
| format | Article |
| id | doaj.art-d874116a00864eab902e702a35381759 |
| institution | Directory Open Access Journal |
| issn | 1938-2723 |
| language | English |
| last_indexed | 2024-12-21T00:25:47Z |
| publishDate | 2020-02-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical and Applied Thrombosis/Hemostasis |
| spelling | doaj.art-d874116a00864eab902e702a353817592022-12-21T19:22:00ZengSAGE PublishingClinical and Applied Thrombosis/Hemostasis1938-27232020-02-012610.1177/1076029619899702Relationship Between 25-Hydroxyvitamin D, Renin, and Collagen Remodeling Biomarkers in Atrial FibrillationDimpi Patel BA0Aleksander Druck BS1Debra Hoppensteadt PhD2Vinod Bansal MD3Yevgeniy Brailovsky DO4Mushabbar Syed MD5Jawed Fareed PhD6 Hemostasis and Thrombosis Laboratories, Center of Translational Research and Education, Maywood, IL, USA Loyola University of Chicago, Stritch School of Medicine, Maywood, IL, USA Hemostasis and Thrombosis Laboratories, Center of Translational Research and Education, Maywood, IL, USA Loyola University Medical Center, Maywood, IL, USA Center for Advanced Cardiac Care, Columbia University Medical Center, New York, NY, USA Loyola University Medical Center, Maywood, IL, USA Hemostasis and Thrombosis Laboratories, Center of Translational Research and Education, Maywood, IL, USAThe interplay between vitamin D, the renin–angiotensin system (RAS), and collagen remodeling has been implicated in the pathogenesis of various cardiovascular diseases. This study sought to explore this relationship in atrial fibrillation (AF) by profiling plasma levels of 25-hydroxyvitamin D, RAS biomarkers, and collagen remodeling biomarkers using the enzyme-linked immunosorbent assay method. We hypothesized that 25-hydroxyvitamin D levels would inversely correlate with RAS biomarkers and that levels of RAS and collagen remodeling biomarkers would positively correlate with each other. Although our AF cohort (n = 37) did not exhibit decreased 25-hydroxyvitamin D levels compared to normal controls (n = 26), these levels inversely correlated with renin (Spearman r = −0.57, P = 0.005). Renin levels were elevated in patients with AF compared to normal controls (1233 ± 238 ng/mL vs 401 ± 27 ng/mL, P = 0.0002) and positively correlated with levels of matrix metalloproteinase 1 (MMP-1; Spearman r = 0.89, P = 0.01) and MMP-2 (Spearman r = 0.82, P = 0.03). These data suggest that 25-hydroxyvitamin D may influence RAS activation, and renin may help mediate the collagen remodeling process in AF. Understanding mediators of RAS dysregulation in AF may elucidate targets for therapeutic intervention to prevent collagen remodeling.https://doi.org/10.1177/1076029619899702 |
| spellingShingle | Dimpi Patel BA Aleksander Druck BS Debra Hoppensteadt PhD Vinod Bansal MD Yevgeniy Brailovsky DO Mushabbar Syed MD Jawed Fareed PhD Relationship Between 25-Hydroxyvitamin D, Renin, and Collagen Remodeling Biomarkers in Atrial Fibrillation Clinical and Applied Thrombosis/Hemostasis |
| title | Relationship Between 25-Hydroxyvitamin D, Renin, and Collagen Remodeling Biomarkers in Atrial Fibrillation |
| title_full | Relationship Between 25-Hydroxyvitamin D, Renin, and Collagen Remodeling Biomarkers in Atrial Fibrillation |
| title_fullStr | Relationship Between 25-Hydroxyvitamin D, Renin, and Collagen Remodeling Biomarkers in Atrial Fibrillation |
| title_full_unstemmed | Relationship Between 25-Hydroxyvitamin D, Renin, and Collagen Remodeling Biomarkers in Atrial Fibrillation |
| title_short | Relationship Between 25-Hydroxyvitamin D, Renin, and Collagen Remodeling Biomarkers in Atrial Fibrillation |
| title_sort | relationship between 25 hydroxyvitamin d renin and collagen remodeling biomarkers in atrial fibrillation |
| url | https://doi.org/10.1177/1076029619899702 |
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