Halogenated Diterpenes with In Vitro Antitumor Activity from the Red Alga <i>Sphaerococcus coronopifolius</i>
Eight new (<b>1</b>−<b>8</b>) structurally diverse diterpenes featuring five different carbocycles were isolated from the organic extracts of the red alga <i>Sphaerococcus coronopifolius</i> collected from the coastline of the Ionian Sea in Greece. The s...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-12-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/18/1/29 |
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| author | Vangelis Smyrniotopoulos Anna Cláudia de Andrade Tomaz Maria de Fátima Vanderlei de Souza Emídio Vasconcelos Leitão da Cunha Robert Kiss Véronique Mathieu Efstathia Ioannou Vassilios Roussis |
| author_facet | Vangelis Smyrniotopoulos Anna Cláudia de Andrade Tomaz Maria de Fátima Vanderlei de Souza Emídio Vasconcelos Leitão da Cunha Robert Kiss Véronique Mathieu Efstathia Ioannou Vassilios Roussis |
| author_sort | Vangelis Smyrniotopoulos |
| collection | DOAJ |
| description | Eight new (<b>1</b>−<b>8</b>) structurally diverse diterpenes featuring five different carbocycles were isolated from the organic extracts of the red alga <i>Sphaerococcus coronopifolius</i> collected from the coastline of the Ionian Sea in Greece. The structures of the new natural products, seven of which were halogenated, and the relative configuration of their stereocenters were determined on the basis of comprehensive spectroscopic analyses, including NMR and HRMS data. Compounds <b>5</b> and <b>8</b> were found to possess in vitro antitumor activity against one murine and five human cancer cell lines with mean IC<sub>50</sub> values 15 and 16 μM, respectively. |
| first_indexed | 2024-12-10T06:29:43Z |
| format | Article |
| id | doaj.art-d877a786724b4f9bbfcf5605d0edbee7 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-12-10T06:29:43Z |
| publishDate | 2019-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-d877a786724b4f9bbfcf5605d0edbee72022-12-22T01:59:07ZengMDPI AGMarine Drugs1660-33972019-12-011812910.3390/md18010029md18010029Halogenated Diterpenes with In Vitro Antitumor Activity from the Red Alga <i>Sphaerococcus coronopifolius</i>Vangelis Smyrniotopoulos0Anna Cláudia de Andrade Tomaz1Maria de Fátima Vanderlei de Souza2Emídio Vasconcelos Leitão da Cunha3Robert Kiss4Véronique Mathieu5Efstathia Ioannou6Vassilios Roussis7Section of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, GreeceSection of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, GreecePostgraduate Program in Bioactive Natural and Synthetic Products, Health Sciences Center, Federal University of Paraíba, João Pessoa 58051-970, PB, BrazilPostgraduate Program in Bioactive Natural and Synthetic Products, Health Sciences Center, Federal University of Paraíba, João Pessoa 58051-970, PB, BrazilFonds National de la Recherche Scientifique, 1050 Bruxelles, BelgiumDepartment of Pharmacotherapy and Pharmaceutics, Université Libre de Bruxelles, Boulevard du Triomphe, 1050 Brussels, BelgiumSection of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, GreeceSection of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, GreeceEight new (<b>1</b>−<b>8</b>) structurally diverse diterpenes featuring five different carbocycles were isolated from the organic extracts of the red alga <i>Sphaerococcus coronopifolius</i> collected from the coastline of the Ionian Sea in Greece. The structures of the new natural products, seven of which were halogenated, and the relative configuration of their stereocenters were determined on the basis of comprehensive spectroscopic analyses, including NMR and HRMS data. Compounds <b>5</b> and <b>8</b> were found to possess in vitro antitumor activity against one murine and five human cancer cell lines with mean IC<sub>50</sub> values 15 and 16 μM, respectively.https://www.mdpi.com/1660-3397/18/1/29<i>sphaerococcus coronopifolius</i>red algaehalogenated diterpenesstructure elucidationantitumor activity |
| spellingShingle | Vangelis Smyrniotopoulos Anna Cláudia de Andrade Tomaz Maria de Fátima Vanderlei de Souza Emídio Vasconcelos Leitão da Cunha Robert Kiss Véronique Mathieu Efstathia Ioannou Vassilios Roussis Halogenated Diterpenes with In Vitro Antitumor Activity from the Red Alga <i>Sphaerococcus coronopifolius</i> Marine Drugs <i>sphaerococcus coronopifolius</i> red algae halogenated diterpenes structure elucidation antitumor activity |
| title | Halogenated Diterpenes with In Vitro Antitumor Activity from the Red Alga <i>Sphaerococcus coronopifolius</i> |
| title_full | Halogenated Diterpenes with In Vitro Antitumor Activity from the Red Alga <i>Sphaerococcus coronopifolius</i> |
| title_fullStr | Halogenated Diterpenes with In Vitro Antitumor Activity from the Red Alga <i>Sphaerococcus coronopifolius</i> |
| title_full_unstemmed | Halogenated Diterpenes with In Vitro Antitumor Activity from the Red Alga <i>Sphaerococcus coronopifolius</i> |
| title_short | Halogenated Diterpenes with In Vitro Antitumor Activity from the Red Alga <i>Sphaerococcus coronopifolius</i> |
| title_sort | halogenated diterpenes with in vitro antitumor activity from the red alga i sphaerococcus coronopifolius i |
| topic | <i>sphaerococcus coronopifolius</i> red algae halogenated diterpenes structure elucidation antitumor activity |
| url | https://www.mdpi.com/1660-3397/18/1/29 |
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