Asthma, Airflow Obstruction, and Eosinophilic Airway Inflammation Prevalence in Western Kenya: A Population-Based Cross-Sectional Study
Objectives: Determine the prevalence of airway disease (e.g., asthma, airflow obstruction, and eosinophilic airway inflammation) in Kenya, as well as related correlates of airway disease and health-related quality of life.Methods: A three-stage, cluster-randomized cross-sectional study in Uasin Gish...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-08-01
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| Series: | International Journal of Public Health |
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| Online Access: | https://www.ssph-journal.org/articles/10.3389/ijph.2023.1606030/full |
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| author | Neelima Navuluri Neelima Navuluri David Lagat Joseph R. Egger Elcy Birgen Lameck Diero David M. Murdoch Nathan Thielman Nathan Thielman Peter S. Kussin Peter S. Kussin Loretta G. Que Devon Paul Devon Paul |
| author_facet | Neelima Navuluri Neelima Navuluri David Lagat Joseph R. Egger Elcy Birgen Lameck Diero David M. Murdoch Nathan Thielman Nathan Thielman Peter S. Kussin Peter S. Kussin Loretta G. Que Devon Paul Devon Paul |
| author_sort | Neelima Navuluri |
| collection | DOAJ |
| description | Objectives: Determine the prevalence of airway disease (e.g., asthma, airflow obstruction, and eosinophilic airway inflammation) in Kenya, as well as related correlates of airway disease and health-related quality of life.Methods: A three-stage, cluster-randomized cross-sectional study in Uasin Gishu County, Kenya was conducted. Individuals 12 years and older completed questionnaires (including St. George’s Respiratory Questionnaire for COPD, SGRQ-C), spirometry, and fractional exhaled nitric oxide (FeNO) testing. Prevalence ratios with 95% confidence intervals (CIs) were calculated. Multivariable models were used to assess correlates of airflow obstruction and high FeNO.Results: Three hundred ninety-two participants completed questionnaires, 369 completed FeNO testing, and 305 completed spirometry. Mean age was 37.5 years; 64% were women. The prevalence of asthma, airflow obstruction on spirometry, and eosinophilic airway inflammation was 21.7%, 12.3% and 15.7% respectively in the population. Women had significantly higher SGRQ-C scores compared to men (15.0 vs. 7.7). Wheezing or whistling in the last year and SGRQ-C scores were strongly associated with FeNO levels >50 ppb after adjusting for age, gender, BMI, and tobacco use.Conclusion: Airway disease is a significant health problem in Kenya affecting a young population who lack a significant tobacco use history. |
| first_indexed | 2024-03-12T14:37:35Z |
| format | Article |
| id | doaj.art-d878a7b0061f4c11ab2b96a8dc67b5d9 |
| institution | Directory Open Access Journal |
| issn | 1661-8564 |
| language | English |
| last_indexed | 2024-03-12T14:37:35Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | International Journal of Public Health |
| spelling | doaj.art-d878a7b0061f4c11ab2b96a8dc67b5d92023-08-17T04:10:56ZengFrontiers Media S.A.International Journal of Public Health1661-85642023-08-016810.3389/ijph.2023.16060301606030Asthma, Airflow Obstruction, and Eosinophilic Airway Inflammation Prevalence in Western Kenya: A Population-Based Cross-Sectional StudyNeelima Navuluri0Neelima Navuluri1David Lagat2Joseph R. Egger3Elcy Birgen4Lameck Diero5David M. Murdoch6Nathan Thielman7Nathan Thielman8Peter S. Kussin9Peter S. Kussin10Loretta G. Que11Devon Paul12Devon Paul13Division of Pulmonary, Allergy and Critical Care, Duke University School of Medicine, Durham, NC, United StatesDuke Global Health Institute, Duke University, Durham, NC, United StatesDepartment of Medicine, Moi University School of Medicine, Eldoret, KenyaDuke Global Health Institute, Duke University, Durham, NC, United StatesDuke Global Health Institute, Duke University, Durham, NC, United StatesDepartment of Medicine, Moi University School of Medicine, Eldoret, KenyaDivision of Pulmonary, Allergy and Critical Care, Duke University School of Medicine, Durham, NC, United StatesDuke Global Health Institute, Duke University, Durham, NC, United StatesDivision of Infectious Disease, Duke University School of Medicine, Durham, NC, United StatesDivision of Pulmonary, Allergy and Critical Care, Duke University School of Medicine, Durham, NC, United StatesDuke Global Health Institute, Duke University, Durham, NC, United StatesDivision of Pulmonary, Allergy and Critical Care, Duke University School of Medicine, Durham, NC, United StatesDivision of Pulmonary and Critical Care, Mt. Sinai Hospital Medical Center, Chicago, IL, United StatesDepartment of Medicine, Rosalind Franklin School of Medicine, North Chicago, IL, United StatesObjectives: Determine the prevalence of airway disease (e.g., asthma, airflow obstruction, and eosinophilic airway inflammation) in Kenya, as well as related correlates of airway disease and health-related quality of life.Methods: A three-stage, cluster-randomized cross-sectional study in Uasin Gishu County, Kenya was conducted. Individuals 12 years and older completed questionnaires (including St. George’s Respiratory Questionnaire for COPD, SGRQ-C), spirometry, and fractional exhaled nitric oxide (FeNO) testing. Prevalence ratios with 95% confidence intervals (CIs) were calculated. Multivariable models were used to assess correlates of airflow obstruction and high FeNO.Results: Three hundred ninety-two participants completed questionnaires, 369 completed FeNO testing, and 305 completed spirometry. Mean age was 37.5 years; 64% were women. The prevalence of asthma, airflow obstruction on spirometry, and eosinophilic airway inflammation was 21.7%, 12.3% and 15.7% respectively in the population. Women had significantly higher SGRQ-C scores compared to men (15.0 vs. 7.7). Wheezing or whistling in the last year and SGRQ-C scores were strongly associated with FeNO levels >50 ppb after adjusting for age, gender, BMI, and tobacco use.Conclusion: Airway disease is a significant health problem in Kenya affecting a young population who lack a significant tobacco use history.https://www.ssph-journal.org/articles/10.3389/ijph.2023.1606030/fullasthmachronic obstructive pulmonary diseaseKenyaspirometrycross-sectional studyepidemiology |
| spellingShingle | Neelima Navuluri Neelima Navuluri David Lagat Joseph R. Egger Elcy Birgen Lameck Diero David M. Murdoch Nathan Thielman Nathan Thielman Peter S. Kussin Peter S. Kussin Loretta G. Que Devon Paul Devon Paul Asthma, Airflow Obstruction, and Eosinophilic Airway Inflammation Prevalence in Western Kenya: A Population-Based Cross-Sectional Study International Journal of Public Health asthma chronic obstructive pulmonary disease Kenya spirometry cross-sectional study epidemiology |
| title | Asthma, Airflow Obstruction, and Eosinophilic Airway Inflammation Prevalence in Western Kenya: A Population-Based Cross-Sectional Study |
| title_full | Asthma, Airflow Obstruction, and Eosinophilic Airway Inflammation Prevalence in Western Kenya: A Population-Based Cross-Sectional Study |
| title_fullStr | Asthma, Airflow Obstruction, and Eosinophilic Airway Inflammation Prevalence in Western Kenya: A Population-Based Cross-Sectional Study |
| title_full_unstemmed | Asthma, Airflow Obstruction, and Eosinophilic Airway Inflammation Prevalence in Western Kenya: A Population-Based Cross-Sectional Study |
| title_short | Asthma, Airflow Obstruction, and Eosinophilic Airway Inflammation Prevalence in Western Kenya: A Population-Based Cross-Sectional Study |
| title_sort | asthma airflow obstruction and eosinophilic airway inflammation prevalence in western kenya a population based cross sectional study |
| topic | asthma chronic obstructive pulmonary disease Kenya spirometry cross-sectional study epidemiology |
| url | https://www.ssph-journal.org/articles/10.3389/ijph.2023.1606030/full |
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