Association between tea consumption and colorectal cancer: a systematic review and meta-analysis of a population-based study
Abstract Purpose A meta-analysis study was performed to systematically assess the association between tea consumption and CRC risk. Methods Cochrane Library, Embase, PubMed, and Web of Science were retrieved to collect articles in English since 24 July 2023. Databases were searched and evaluated by...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | BMC Gastroenterology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12876-023-02928-8 |
| _version_ | 1797559363580198912 |
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| author | Yu Huang Qiang Chen Yating Liu Ruoxi Tian Xu Yin Yaoguang Hao Yang Yang Jian Yang Zongxuan Li Suyang Yu Hongyan Li Guiying Wang |
| author_facet | Yu Huang Qiang Chen Yating Liu Ruoxi Tian Xu Yin Yaoguang Hao Yang Yang Jian Yang Zongxuan Li Suyang Yu Hongyan Li Guiying Wang |
| author_sort | Yu Huang |
| collection | DOAJ |
| description | Abstract Purpose A meta-analysis study was performed to systematically assess the association between tea consumption and CRC risk. Methods Cochrane Library, Embase, PubMed, and Web of Science were retrieved to collect articles in English since 24 July 2023. Databases were searched and evaluated by two reviewers independently.We screened the literature based on inclusion and exclusion criteria. After determining the random effect model or fixed utility model based on a heterogeneity test, odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Results We included fourteen articles in this meta-analysis. We analyzed the data using a random effect model to explore the association between tea consumption and CRC because of apparent heterogeneity (P < 0.001, I2 = 99.5%). The combined results of all tests showed that there is no statistically significant association between tea consumption and CRC risk (OR = 0.756, 95%CI = 0.470–1.215, P = 0.247). Subsequently, subgroup analysis and sensitivity analysis were performed. Excluding any single study, the overall results ranged from 0.73 (95%CI = 0.44–1.20) to 0.86 (95%CI = 0.53–1.40). It was determined that there was no significant publication bias between tea consumption and CRC risk (P = 0.064) by Egger's tests. Conclusions The results indicated that tea consumption may not be significantly associated with the development of CRC. Implications of key findings Tea reduces colon cancer risk by 24%, but the estimate is uncertain. The actual effect on risk can range from a reduction of 51% to an increase of 18%, but regional and population differences may cause differences. |
| first_indexed | 2024-03-10T17:44:18Z |
| format | Article |
| id | doaj.art-d879817f388d48eea4dba8e52e305cf4 |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-03-10T17:44:18Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-d879817f388d48eea4dba8e52e305cf42023-11-20T09:36:30ZengBMCBMC Gastroenterology1471-230X2023-08-0123111010.1186/s12876-023-02928-8Association between tea consumption and colorectal cancer: a systematic review and meta-analysis of a population-based studyYu Huang0Qiang Chen1Yating Liu2Ruoxi Tian3Xu Yin4Yaoguang Hao5Yang Yang6Jian Yang7Zongxuan Li8Suyang Yu9Hongyan Li10Guiying Wang11Department of Gastrointestinal Surgery, The Third Hospital of Hebei Medical UniversityDepartment of Gastrointestinal Surgery, The Third Hospital of Hebei Medical UniversityDepartment of Gastrointestinal Surgery, The Third Hospital of Hebei Medical UniversityDepartment of Clinical Medical College, Tianjin Medical UniversityDepartment of Gastrointestinal Surgery, The Third Hospital of Hebei Medical UniversityDepartment of Gastrointestinal Surgery, The Third Hospital of Hebei Medical UniversityDepartment of Gastrointestinal Surgery, The Third Hospital of Hebei Medical UniversityDepartment of Thoracic Surgery Gastrointestinal Surgery, the Third Hospital of Hebei Medical UniversityDepartment of Vascular Surgery Gastrointestinal Surgery, the Third Hospital of Hebei Medical UniversityDepartment of Gastrointestinal Surgery, The Third Hospital of Hebei Medical UniversityDepartment of Gastrointestinal Surgery, The Third Hospital of Hebei Medical UniversityDepartment of Gastrointestinal Surgery, The Third Hospital of Hebei Medical UniversityAbstract Purpose A meta-analysis study was performed to systematically assess the association between tea consumption and CRC risk. Methods Cochrane Library, Embase, PubMed, and Web of Science were retrieved to collect articles in English since 24 July 2023. Databases were searched and evaluated by two reviewers independently.We screened the literature based on inclusion and exclusion criteria. After determining the random effect model or fixed utility model based on a heterogeneity test, odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Results We included fourteen articles in this meta-analysis. We analyzed the data using a random effect model to explore the association between tea consumption and CRC because of apparent heterogeneity (P < 0.001, I2 = 99.5%). The combined results of all tests showed that there is no statistically significant association between tea consumption and CRC risk (OR = 0.756, 95%CI = 0.470–1.215, P = 0.247). Subsequently, subgroup analysis and sensitivity analysis were performed. Excluding any single study, the overall results ranged from 0.73 (95%CI = 0.44–1.20) to 0.86 (95%CI = 0.53–1.40). It was determined that there was no significant publication bias between tea consumption and CRC risk (P = 0.064) by Egger's tests. Conclusions The results indicated that tea consumption may not be significantly associated with the development of CRC. Implications of key findings Tea reduces colon cancer risk by 24%, but the estimate is uncertain. The actual effect on risk can range from a reduction of 51% to an increase of 18%, but regional and population differences may cause differences.https://doi.org/10.1186/s12876-023-02928-8Tea consumptionCRCPopulation-based studyMeta-analysisSystematic review |
| spellingShingle | Yu Huang Qiang Chen Yating Liu Ruoxi Tian Xu Yin Yaoguang Hao Yang Yang Jian Yang Zongxuan Li Suyang Yu Hongyan Li Guiying Wang Association between tea consumption and colorectal cancer: a systematic review and meta-analysis of a population-based study BMC Gastroenterology Tea consumption CRC Population-based study Meta-analysis Systematic review |
| title | Association between tea consumption and colorectal cancer: a systematic review and meta-analysis of a population-based study |
| title_full | Association between tea consumption and colorectal cancer: a systematic review and meta-analysis of a population-based study |
| title_fullStr | Association between tea consumption and colorectal cancer: a systematic review and meta-analysis of a population-based study |
| title_full_unstemmed | Association between tea consumption and colorectal cancer: a systematic review and meta-analysis of a population-based study |
| title_short | Association between tea consumption and colorectal cancer: a systematic review and meta-analysis of a population-based study |
| title_sort | association between tea consumption and colorectal cancer a systematic review and meta analysis of a population based study |
| topic | Tea consumption CRC Population-based study Meta-analysis Systematic review |
| url | https://doi.org/10.1186/s12876-023-02928-8 |
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