Unveiling the spatial metabolome and anti-atherosclerosis effects of Allium macrostemon Bunge and Allium chinense G. Don
Allium macrostemon Bunge (AMB) and Allium chinense G. Don (ACGD) are both the medicinal herbs of Allii Macrostemonis Bulbus (also named Xiebai in Chinese) for the treatment of coronary heart disease. However, the similarities and differences of anti-atherosclerosis effects and chemical profiles of A...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Arabian Journal of Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535223002344 |
| _version_ | 1797846385547018240 |
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| author | Songyang Li Pei Lin Han Xing Xinqiang Li Zhihong Yao Xiaojian Zhang Xinsheng Yao Jing Yang Zifei Qin |
| author_facet | Songyang Li Pei Lin Han Xing Xinqiang Li Zhihong Yao Xiaojian Zhang Xinsheng Yao Jing Yang Zifei Qin |
| author_sort | Songyang Li |
| collection | DOAJ |
| description | Allium macrostemon Bunge (AMB) and Allium chinense G. Don (ACGD) are both the medicinal herbs of Allii Macrostemonis Bulbus (also named Xiebai in Chinese) for the treatment of coronary heart disease. However, the similarities and differences of anti-atherosclerosis effects and chemical profiles of AMB and ACGD still remain unclear. Similarly, comparative analysis of the spatial metabolomes of AMB and ACGD has rarely been performed. First, biochemical and pathological results demonstrated that AMB and ACGD extracts exhibited similar and close lipid-lowering activity and anti-atherosclerosis effect. Further, a total of 693 metabolites were identified or tentatively characterized by UHPLC-MS/MS and UHPLC-TOF/MS. And 365 differential compounds were determined between AMB and ACGD involving in carbohydrate and aldarate metabolism, purine metabolism, linoleic acid metabolism, α-linoleic acid metabolism, phenylalanine and tyrosine metabolism. Moreover, MALDI-TOF IMS-mediated spatial metabolome given the biosynthesis pathways of steroidal saponins, flavonoids, lignans for the first time. These compounds were rich in AMB tunic and outside scales, whereas they were mainly distributed in ACGD tunic, whole leaf scales, and rarely in developing flower buds. Taken together, these findings provided abundant information about pharmacological effects, chemical profiling and visual spatial distribution of AMB and ACGD, and would benefit the application and promotion of their relative products on the market. |
| first_indexed | 2024-04-09T17:55:12Z |
| format | Article |
| id | doaj.art-d8799da38e0a40c58741cb49a0fd873a |
| institution | Directory Open Access Journal |
| issn | 1878-5352 |
| language | English |
| last_indexed | 2024-04-09T17:55:12Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arabian Journal of Chemistry |
| spelling | doaj.art-d8799da38e0a40c58741cb49a0fd873a2023-04-15T05:52:16ZengElsevierArabian Journal of Chemistry1878-53522023-06-01166104772Unveiling the spatial metabolome and anti-atherosclerosis effects of Allium macrostemon Bunge and Allium chinense G. DonSongyang Li0Pei Lin1Han Xing2Xinqiang Li3Zhihong Yao4Xiaojian Zhang5Xinsheng Yao6Jing Yang7Zifei Qin8Department of Pharmacy, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, ChinaCollege of Pharmacy, Jinan University, Guangzhou 510632, ChinaDepartment of Pharmacy, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Henan Engineering Research Center for Application & Translation of Precision Clinical Pharmacy, Zhengzhou University, Zhengzhou 450052, ChinaDepartment of Pathology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, ChinaCollege of Pharmacy, Jinan University, Guangzhou 510632, ChinaDepartment of Pharmacy, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Henan Engineering Research Center for Application & Translation of Precision Clinical Pharmacy, Zhengzhou University, Zhengzhou 450052, ChinaCollege of Pharmacy, Jinan University, Guangzhou 510632, ChinaDepartment of Pharmacy, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Henan Engineering Research Center for Application & Translation of Precision Clinical Pharmacy, Zhengzhou University, Zhengzhou 450052, China; Corresponding authors at: Department of Pharmacy, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.Department of Pharmacy, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Henan Engineering Research Center for Application & Translation of Precision Clinical Pharmacy, Zhengzhou University, Zhengzhou 450052, China; Corresponding authors at: Department of Pharmacy, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.Allium macrostemon Bunge (AMB) and Allium chinense G. Don (ACGD) are both the medicinal herbs of Allii Macrostemonis Bulbus (also named Xiebai in Chinese) for the treatment of coronary heart disease. However, the similarities and differences of anti-atherosclerosis effects and chemical profiles of AMB and ACGD still remain unclear. Similarly, comparative analysis of the spatial metabolomes of AMB and ACGD has rarely been performed. First, biochemical and pathological results demonstrated that AMB and ACGD extracts exhibited similar and close lipid-lowering activity and anti-atherosclerosis effect. Further, a total of 693 metabolites were identified or tentatively characterized by UHPLC-MS/MS and UHPLC-TOF/MS. And 365 differential compounds were determined between AMB and ACGD involving in carbohydrate and aldarate metabolism, purine metabolism, linoleic acid metabolism, α-linoleic acid metabolism, phenylalanine and tyrosine metabolism. Moreover, MALDI-TOF IMS-mediated spatial metabolome given the biosynthesis pathways of steroidal saponins, flavonoids, lignans for the first time. These compounds were rich in AMB tunic and outside scales, whereas they were mainly distributed in ACGD tunic, whole leaf scales, and rarely in developing flower buds. Taken together, these findings provided abundant information about pharmacological effects, chemical profiling and visual spatial distribution of AMB and ACGD, and would benefit the application and promotion of their relative products on the market.http://www.sciencedirect.com/science/article/pii/S1878535223002344Allium macrostemon BungeAllium chinense G. DonAnti-atherosclerosis effectsPrimary and secondary metabolitesSpatial distributionBiosynthesis pathway |
| spellingShingle | Songyang Li Pei Lin Han Xing Xinqiang Li Zhihong Yao Xiaojian Zhang Xinsheng Yao Jing Yang Zifei Qin Unveiling the spatial metabolome and anti-atherosclerosis effects of Allium macrostemon Bunge and Allium chinense G. Don Arabian Journal of Chemistry Allium macrostemon Bunge Allium chinense G. Don Anti-atherosclerosis effects Primary and secondary metabolites Spatial distribution Biosynthesis pathway |
| title | Unveiling the spatial metabolome and anti-atherosclerosis effects of Allium macrostemon Bunge and Allium chinense G. Don |
| title_full | Unveiling the spatial metabolome and anti-atherosclerosis effects of Allium macrostemon Bunge and Allium chinense G. Don |
| title_fullStr | Unveiling the spatial metabolome and anti-atherosclerosis effects of Allium macrostemon Bunge and Allium chinense G. Don |
| title_full_unstemmed | Unveiling the spatial metabolome and anti-atherosclerosis effects of Allium macrostemon Bunge and Allium chinense G. Don |
| title_short | Unveiling the spatial metabolome and anti-atherosclerosis effects of Allium macrostemon Bunge and Allium chinense G. Don |
| title_sort | unveiling the spatial metabolome and anti atherosclerosis effects of allium macrostemon bunge and allium chinense g don |
| topic | Allium macrostemon Bunge Allium chinense G. Don Anti-atherosclerosis effects Primary and secondary metabolites Spatial distribution Biosynthesis pathway |
| url | http://www.sciencedirect.com/science/article/pii/S1878535223002344 |
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