BRD2 induces drug resistance through activation of the RasGRP1/Ras/ERK signaling pathway in adult T‐cell lymphoblastic lymphoma

BRD2 induces drug resistance through activation of the RasGRP1/Ras/ERK signaling pathway in adult T‐cell lymphoblastic lymphoma

Abstract Background Adult patients with T‐cell lymphoblastic lymphoma (T‐LBL) are treated with high‐intensity chemotherapy regimens, but the response rate is still unsatisfactory because of frequent drug resistance. We aimed to investigate the potential mechanisms of drug resistance in adults with T...

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Main Authors: Xiao‐Peng Tian, Jun Cai, Shu‐Yun Ma, Yu Fang, Hui‐Qiang Huang, Tong‐Yu Lin, Hui‐Lan Rao, Mei Li, Zhong‐Jun Xia, Tie‐Bang Kang, Dan Xie, Qing‐Qing Cai
Format: Article
Language:English
Published: Wiley 2020-06-01
Series:Cancer Communications
Subjects:
T‐cell Lymphoblastic Lymphoma
drug resistance
BRD2
MEK
ERK
c‐Myc
Online Access:https://doi.org/10.1002/cac2.12039

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