Genome-wide association study of relative telomere length.
Telomere function is essential to maintaining the physical integrity of linear chromosomes and healthy human aging. The probability of forming proper telomere structures depends on the length of the telomeric DNA tract. We attempted to identify common genetic variants associated with log relative te...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2011-05-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3091863?pdf=render |
| _version_ | 1818313691196555264 |
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| author | Jennifer Prescott Peter Kraft Daniel I Chasman Sharon A Savage Lisa Mirabello Sonja I Berndt Joel L Weissfeld Jiali Han Richard B Hayes Stephen J Chanock David J Hunter Immaculata De Vivo |
| author_facet | Jennifer Prescott Peter Kraft Daniel I Chasman Sharon A Savage Lisa Mirabello Sonja I Berndt Joel L Weissfeld Jiali Han Richard B Hayes Stephen J Chanock David J Hunter Immaculata De Vivo |
| author_sort | Jennifer Prescott |
| collection | DOAJ |
| description | Telomere function is essential to maintaining the physical integrity of linear chromosomes and healthy human aging. The probability of forming proper telomere structures depends on the length of the telomeric DNA tract. We attempted to identify common genetic variants associated with log relative telomere length using genome-wide genotyping data on 3,554 individuals from the Nurses' Health Study and the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial that took part in the National Cancer Institute Cancer Genetic Markers of Susceptibility initiative for breast and prostate cancer. After genotyping 64 independent SNPs selected for replication in additional Nurses' Health Study and Women's Genome Health Study participants, we did not identify genome-wide significant loci; however, we replicated the inverse association of log relative telomere length with the minor allele variant [C] of rs16847897 at the TERC locus (per allele β = -0.03, P = 0.003) identified by a previous genome-wide association study. We did not find evidence for an association with variants at the OBFC1 locus or other loci reported to be associated with telomere length. With this sample size we had >80% power to detect β estimates as small as ±0.10 for SNPs with minor allele frequencies of ≥0.15 at genome-wide significance. However, power is greatly reduced for β estimates smaller than ±0.10, such as those for variants at the TERC locus. In general, common genetic variants associated with telomere length homeostasis have been difficult to detect. Potential biological and technical issues are discussed. |
| first_indexed | 2024-12-13T08:37:46Z |
| format | Article |
| id | doaj.art-d87b6564a2b64686a51dcd113fc321cc |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T08:37:46Z |
| publishDate | 2011-05-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-d87b6564a2b64686a51dcd113fc321cc2022-12-21T23:53:37ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-05-0165e1963510.1371/journal.pone.0019635Genome-wide association study of relative telomere length.Jennifer PrescottPeter KraftDaniel I ChasmanSharon A SavageLisa MirabelloSonja I BerndtJoel L WeissfeldJiali HanRichard B HayesStephen J ChanockDavid J HunterImmaculata De VivoTelomere function is essential to maintaining the physical integrity of linear chromosomes and healthy human aging. The probability of forming proper telomere structures depends on the length of the telomeric DNA tract. We attempted to identify common genetic variants associated with log relative telomere length using genome-wide genotyping data on 3,554 individuals from the Nurses' Health Study and the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial that took part in the National Cancer Institute Cancer Genetic Markers of Susceptibility initiative for breast and prostate cancer. After genotyping 64 independent SNPs selected for replication in additional Nurses' Health Study and Women's Genome Health Study participants, we did not identify genome-wide significant loci; however, we replicated the inverse association of log relative telomere length with the minor allele variant [C] of rs16847897 at the TERC locus (per allele β = -0.03, P = 0.003) identified by a previous genome-wide association study. We did not find evidence for an association with variants at the OBFC1 locus or other loci reported to be associated with telomere length. With this sample size we had >80% power to detect β estimates as small as ±0.10 for SNPs with minor allele frequencies of ≥0.15 at genome-wide significance. However, power is greatly reduced for β estimates smaller than ±0.10, such as those for variants at the TERC locus. In general, common genetic variants associated with telomere length homeostasis have been difficult to detect. Potential biological and technical issues are discussed.http://europepmc.org/articles/PMC3091863?pdf=render |
| spellingShingle | Jennifer Prescott Peter Kraft Daniel I Chasman Sharon A Savage Lisa Mirabello Sonja I Berndt Joel L Weissfeld Jiali Han Richard B Hayes Stephen J Chanock David J Hunter Immaculata De Vivo Genome-wide association study of relative telomere length. PLoS ONE |
| title | Genome-wide association study of relative telomere length. |
| title_full | Genome-wide association study of relative telomere length. |
| title_fullStr | Genome-wide association study of relative telomere length. |
| title_full_unstemmed | Genome-wide association study of relative telomere length. |
| title_short | Genome-wide association study of relative telomere length. |
| title_sort | genome wide association study of relative telomere length |
| url | http://europepmc.org/articles/PMC3091863?pdf=render |
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