| Summary: | Objective: Large arteries stiffness is a feature of arterial aging and a predictor of cardiovascular diseases. The length of telomere (TL) in leukocytes is widely considered as a biomarker for cellular aging, cardiovascular aging and cardiovascular diseases. High concentrations of urea is known to increase oxidative stress. The aim of our study was to determine whether the indicators of renal function are associated with TL and arterial stiffness, evaluated by measuring aortic pulse wave velocity (PWV).
Methods: The study group included 150 subjects free of known cardiovascular diseases, kidney diseases, anti-diabetes, antihypertensive and lipid lowering medications. PWV was measured with the help of SphygmoCor (AtCor Medical). Telomere length has been determined by quantitative polymerase chain reaction. Renal function was assessed by creatinine clearance calculated with the MDRD formula . Microalbuminuria (MAU) and urea levels were determined using routine laboratory methods.
Results: Pearson’s correlations are demonstrated in the table 1 and table 2.
TL
Age
r= −0,2860
p= 0,0003
Creatinine clearance (ml/min)
r= −0,4267
p= 0,0167
MAU (mg/l)
r= −0,2718
p= 0,0175
Urea (mmol/l)
r= −0,2521
p= 0,0098
PWV
Age
r= 0,5223
p= 0,0001
TL
r= −0,2657
p= 0,0096
Creatinine clearance (ml/min)
r= 0,1964
p= 0,2814
MAU (mg/l)
r= 0,0186
p= 0,8544
Urea (mmol/l)
r= 0,1784
p= 0,0384
In conclusion, even physiological concentrations of plasma urea contribute to cellular and vascular aging. TL may play a role in kidney function. The relationship between TL and kidney repair and regeneration needs increasing studies.
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