Adenovirus-mediated Sirt1 and Tgfbr2 gene therapy improves fertility in natural ovarian aging and doxorubicin-induced premature ovarian insufficiency mice

Adenovirus-mediated Sirt1 and Tgfbr2 gene therapy improves fertility in natural ovarian aging and doxorubicin-induced premature ovarian insufficiency mice

Premature ovarian insufficiency (POI) may lead to early menopause, fertility loss and birth defects without effective treatment. Here, we explored the efficacy and safety of gene therapy to rescue ovarian function in both natural ovarian aging and doxorubicin (Dox) induced POI mice. Sirt1 and Tgfbr2...

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Bibliographic Details
Main Authors: Lingwei Ma, Huan Lu, Xiaofan Gao, Yue Su, Yanzhi Feng, Qianyu Zhang, Peiya Fan, Qian Chen, Jingyi Wen, Tong Wu, Yan Zhang, Bo Wang, Xianan Tang, Yueyue Gao, Yan Li, Su Zhou, Meng Wu, Pengfei Cui, Jinjin Zhang, Shixuan Wang
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Materials & Design
Subjects:
Fertility
Gene therapy
Ovarian aging
Premature ovarian insufficiency
Online Access:http://www.sciencedirect.com/science/article/pii/S0264127524000650

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