Multiple cerebral melanoma metastases with unknown primary tumor location: A case report
Introduction. Diagnostic and therapeutic approach of multiple cerebral lesions is often challenging. Case report. A 66-year-old man with unremarkable medical history was admitted to our hospital for recent inability and stereotyped movements of the left upper limb. Brain MRI identified eight tumor...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Amaltea Medical Publishing House
2017-12-01
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| Series: | Romanian Journal of Neurology |
| Subjects: | |
| Online Access: | https://rjn.com.ro/articles/2017.4/RJN_2017_4_Art-09.pdf |
| _version_ | 1798000281472991232 |
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| author | Liviu Cozma Delia Tulba Maria Barsevschi Cristina Mitu Laura Dumitrescu Radu Tanasescu Bogdan Ovidiu Popescu |
| author_facet | Liviu Cozma Delia Tulba Maria Barsevschi Cristina Mitu Laura Dumitrescu Radu Tanasescu Bogdan Ovidiu Popescu |
| author_sort | Liviu Cozma |
| collection | DOAJ |
| description | Introduction. Diagnostic and therapeutic approach of multiple cerebral lesions is often challenging.
Case report. A 66-year-old man with unremarkable medical history was admitted to our hospital for recent inability and stereotyped movements of the left upper limb. Brain MRI identified eight tumoral masses with contrast enhancement and marked SWI signal loss that displayed increased metabolic activity on 18F-FDG PET/CT scan. Cerebral biopsy led to the diagnosis of melanoma with BRAF V600E mutation. Stereotactic radiosurgery and molecular therapy were planned afterwards.
Conclusion. Brain MRI is a useful tool in guiding diagnosis of cerebral metastases of unknown origin. |
| first_indexed | 2024-04-11T11:17:43Z |
| format | Article |
| id | doaj.art-d87eb211c4094629920990f0268fc29b |
| institution | Directory Open Access Journal |
| issn | 1843-8148 2069-6094 |
| language | English |
| last_indexed | 2024-04-11T11:17:43Z |
| publishDate | 2017-12-01 |
| publisher | Amaltea Medical Publishing House |
| record_format | Article |
| series | Romanian Journal of Neurology |
| spelling | doaj.art-d87eb211c4094629920990f0268fc29b2022-12-22T04:27:09ZengAmaltea Medical Publishing HouseRomanian Journal of Neurology1843-81482069-60942017-12-0116417517810.37897/RJN.2017.4.9Multiple cerebral melanoma metastases with unknown primary tumor location: A case reportLiviu Cozma0Delia Tulba1Maria Barsevschi2Cristina Mitu3Laura Dumitrescu4Radu Tanasescu5Bogdan Ovidiu Popescu6Department of Neurology, Colentina Clinical Hospital, Bucharest, RomaniaDepartment of Neurology, Colentina Clinical Hospital, Bucharest, RomaniaDepartment of Neurology, Colentina Clinical Hospital, Bucharest, RomaniaDepartment of Neurology, Colentina Clinical Hospital, Bucharest, RomaniaDepartment of Neurology, Colentina Clinical Hospital, Bucharest, Romania; “Carol Davila” University of Medicine and Pharmacy, Bucharest, RomaniaDepartment of Neurology, Colentina Clinical Hospital, Bucharest, Romania; “Carol Davila” University of Medicine and Pharmacy, Bucharest, RomaniaDepartment of Neurology, Colentina Clinical Hospital, Bucharest, Romania; “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania; Department of Molecular Medicine, “Victor Babes” National Institute of Pathology, Bucharest, RomaniaIntroduction. Diagnostic and therapeutic approach of multiple cerebral lesions is often challenging. Case report. A 66-year-old man with unremarkable medical history was admitted to our hospital for recent inability and stereotyped movements of the left upper limb. Brain MRI identified eight tumoral masses with contrast enhancement and marked SWI signal loss that displayed increased metabolic activity on 18F-FDG PET/CT scan. Cerebral biopsy led to the diagnosis of melanoma with BRAF V600E mutation. Stereotactic radiosurgery and molecular therapy were planned afterwards. Conclusion. Brain MRI is a useful tool in guiding diagnosis of cerebral metastases of unknown origin.https://rjn.com.ro/articles/2017.4/RJN_2017_4_Art-09.pdfcerebral metastasesunknown primary tumormelanomabraf mutationswi hypointensityfluid-blood level |
| spellingShingle | Liviu Cozma Delia Tulba Maria Barsevschi Cristina Mitu Laura Dumitrescu Radu Tanasescu Bogdan Ovidiu Popescu Multiple cerebral melanoma metastases with unknown primary tumor location: A case report Romanian Journal of Neurology cerebral metastases unknown primary tumor melanoma braf mutation swi hypointensity fluid-blood level |
| title | Multiple cerebral melanoma metastases with unknown primary tumor location: A case report |
| title_full | Multiple cerebral melanoma metastases with unknown primary tumor location: A case report |
| title_fullStr | Multiple cerebral melanoma metastases with unknown primary tumor location: A case report |
| title_full_unstemmed | Multiple cerebral melanoma metastases with unknown primary tumor location: A case report |
| title_short | Multiple cerebral melanoma metastases with unknown primary tumor location: A case report |
| title_sort | multiple cerebral melanoma metastases with unknown primary tumor location a case report |
| topic | cerebral metastases unknown primary tumor melanoma braf mutation swi hypointensity fluid-blood level |
| url | https://rjn.com.ro/articles/2017.4/RJN_2017_4_Art-09.pdf |
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