Male Breast Carcinoma Metastatic to the Choroid: A Case Report and Opinions of Management
Weida Fu,* Shurong Zheng,* Jieyu Zhou, Kangkang Lu, Yiqiao Lu, Guilong Guo Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Gu...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-02-01
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| Series: | Cancer Management and Research |
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| Online Access: | https://www.dovepress.com/male-breast-carcinoma-metastatic-to-the-choroid-a-case-report-and-opin-peer-reviewed-fulltext-article-CMAR |
| _version_ | 1831568249785942016 |
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| author | Fu W Zheng S Zhou J Lu K Lu Y Guo G |
| author_facet | Fu W Zheng S Zhou J Lu K Lu Y Guo G |
| author_sort | Fu W |
| collection | DOAJ |
| description | Weida Fu,* Shurong Zheng,* Jieyu Zhou, Kangkang Lu, Yiqiao Lu, Guilong Guo Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Guilong Guo, Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China, Tel/Fax +86-13867709361, Email guoguilong@sina.comAbstract: Male breast carcinoma metastatic to the choroid is very rare and often related to poor prognosis. Herein, we report the findings in a Chinese male breast cancer patient who developed choroidal metastasis, and give opinions on systemic treatments. A 45-year-old Chinese male represented with difficulty breathing and visual impairment in the left eye 6 years after his breast cancer surgery and postoperative adjuvant treatment. PET/CT revealed multi-organs metastasis of the patient. The IHC indicated the lung lesion to be originated from the breast (ER+/PR+/HER2-). Eye examination provided evidence for breast cancer choroidal metastasis. Two cycles of TX (docetaxel + capecitabine) followed by two courses of GP (gemcitabine + cis-platinum) were applied as salvage chemotherapy. Metastases in his lung and bone remained stable. As for choroidal metastasis, a regimen of CDK4/6 inhibitor (Palbociclib) plus fulvestrant was recommended to the patient, which led to a good response. Notably, CDK4/6 inhibitor combined with endocrine therapy may be considered as an effective treatment for hormonal receptor-positive breast cancer patients with choroidal metastasis. We recommend that eye examination should not be neglected in breast cancer patients.Keywords: choroidal metastasis, male breast cancer, systemic therapy, CDK4/6 inhibitor, case report |
| first_indexed | 2024-12-17T12:12:44Z |
| format | Article |
| id | doaj.art-d87fc6a63531430db9627b66654cf617 |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-12-17T12:12:44Z |
| publishDate | 2022-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-d87fc6a63531430db9627b66654cf6172022-12-21T21:49:19ZengDove Medical PressCancer Management and Research1179-13222022-02-01Volume 1452553472805Male Breast Carcinoma Metastatic to the Choroid: A Case Report and Opinions of ManagementFu WZheng SZhou JLu KLu YGuo GWeida Fu,* Shurong Zheng,* Jieyu Zhou, Kangkang Lu, Yiqiao Lu, Guilong Guo Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Guilong Guo, Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China, Tel/Fax +86-13867709361, Email guoguilong@sina.comAbstract: Male breast carcinoma metastatic to the choroid is very rare and often related to poor prognosis. Herein, we report the findings in a Chinese male breast cancer patient who developed choroidal metastasis, and give opinions on systemic treatments. A 45-year-old Chinese male represented with difficulty breathing and visual impairment in the left eye 6 years after his breast cancer surgery and postoperative adjuvant treatment. PET/CT revealed multi-organs metastasis of the patient. The IHC indicated the lung lesion to be originated from the breast (ER+/PR+/HER2-). Eye examination provided evidence for breast cancer choroidal metastasis. Two cycles of TX (docetaxel + capecitabine) followed by two courses of GP (gemcitabine + cis-platinum) were applied as salvage chemotherapy. Metastases in his lung and bone remained stable. As for choroidal metastasis, a regimen of CDK4/6 inhibitor (Palbociclib) plus fulvestrant was recommended to the patient, which led to a good response. Notably, CDK4/6 inhibitor combined with endocrine therapy may be considered as an effective treatment for hormonal receptor-positive breast cancer patients with choroidal metastasis. We recommend that eye examination should not be neglected in breast cancer patients.Keywords: choroidal metastasis, male breast cancer, systemic therapy, CDK4/6 inhibitor, case reporthttps://www.dovepress.com/male-breast-carcinoma-metastatic-to-the-choroid-a-case-report-and-opin-peer-reviewed-fulltext-article-CMARchoroidal metastasismale breast cancersystemic therapycdk4/6 inhibitorcase report |
| spellingShingle | Fu W Zheng S Zhou J Lu K Lu Y Guo G Male Breast Carcinoma Metastatic to the Choroid: A Case Report and Opinions of Management Cancer Management and Research choroidal metastasis male breast cancer systemic therapy cdk4/6 inhibitor case report |
| title | Male Breast Carcinoma Metastatic to the Choroid: A Case Report and Opinions of Management |
| title_full | Male Breast Carcinoma Metastatic to the Choroid: A Case Report and Opinions of Management |
| title_fullStr | Male Breast Carcinoma Metastatic to the Choroid: A Case Report and Opinions of Management |
| title_full_unstemmed | Male Breast Carcinoma Metastatic to the Choroid: A Case Report and Opinions of Management |
| title_short | Male Breast Carcinoma Metastatic to the Choroid: A Case Report and Opinions of Management |
| title_sort | male breast carcinoma metastatic to the choroid a case report and opinions of management |
| topic | choroidal metastasis male breast cancer systemic therapy cdk4/6 inhibitor case report |
| url | https://www.dovepress.com/male-breast-carcinoma-metastatic-to-the-choroid-a-case-report-and-opin-peer-reviewed-fulltext-article-CMAR |
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