Anti-inflammatory effect of gold nanoparticles supported on metal oxides
Abstract Gold (Au) can be deposited as nanoparticles (NPs) smaller than 10 nm in diameter on a variety of metal oxide (MOx) NPs. Au/MOx have high catalytic performance and selective oxidation capacity which could have implications in terms of biological activity, and more specifically in modulation...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-02419-4 |
| _version_ | 1818404171071619072 |
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| author | Takashi Fujita Maeva Zysman Dan Elgrabli Toru Murayama Masatake Haruta Sophie Lanone Tamao Ishida Jorge Boczkowski |
| author_facet | Takashi Fujita Maeva Zysman Dan Elgrabli Toru Murayama Masatake Haruta Sophie Lanone Tamao Ishida Jorge Boczkowski |
| author_sort | Takashi Fujita |
| collection | DOAJ |
| description | Abstract Gold (Au) can be deposited as nanoparticles (NPs) smaller than 10 nm in diameter on a variety of metal oxide (MOx) NPs. Au/MOx have high catalytic performance and selective oxidation capacity which could have implications in terms of biological activity, and more specifically in modulation of the inflammatory reaction. Therefore, the aim of this study was to examine the effect of Au/TiO2, Au/ZrO2 and Au/CeO2 on viability, phagocytic capacity and inflammatory profile (TNF-α and IL-1β secretion) of murine macrophages. The most important result of this study is an anti-inflammatory effect of Au/MOx depending on the MOx nature with particle internalization and no alteration of cell viability and phagocytosis. The effect was dependent on the MOx NPs chemical nature (Au/TiO2 > Au/ZrO2 > Au/CeO2 if we consider the number of cytokines whose concentration was reduced by the NPs), and on the inflammatory mediator considered. The effect of Au/TiO2 NPs was not related to Au NPs size (at least in the case of Au/TiO2 NPs in the range of 3–8 nm). To the best of our knowledge, this is the first demonstration of an anti-inflammatory effect of Au/MOx. |
| first_indexed | 2024-12-14T08:35:54Z |
| format | Article |
| id | doaj.art-d88168994f274626b60d9f985c2624b7 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-14T08:35:54Z |
| publishDate | 2021-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-d88168994f274626b60d9f985c2624b72022-12-21T23:09:25ZengNature PortfolioScientific Reports2045-23222021-11-0111111010.1038/s41598-021-02419-4Anti-inflammatory effect of gold nanoparticles supported on metal oxidesTakashi Fujita0Maeva Zysman1Dan Elgrabli2Toru Murayama3Masatake Haruta4Sophie Lanone5Tamao Ishida6Jorge Boczkowski7Department of Applied Chemistry for Environment, Graduate School of Urban Environmental Sciences, Tokyo Metropolitan UniversityUniv Paris est Creteil, INSERM, IMRBUniv Paris est Creteil, INSERM, IMRBDepartment of Applied Chemistry for Environment, Graduate School of Urban Environmental Sciences, Tokyo Metropolitan UniversityDepartment of Applied Chemistry for Environment, Graduate School of Urban Environmental Sciences, Tokyo Metropolitan UniversityUniv Paris est Creteil, INSERM, IMRBDepartment of Applied Chemistry for Environment, Graduate School of Urban Environmental Sciences, Tokyo Metropolitan UniversityUniv Paris est Creteil, INSERM, IMRBAbstract Gold (Au) can be deposited as nanoparticles (NPs) smaller than 10 nm in diameter on a variety of metal oxide (MOx) NPs. Au/MOx have high catalytic performance and selective oxidation capacity which could have implications in terms of biological activity, and more specifically in modulation of the inflammatory reaction. Therefore, the aim of this study was to examine the effect of Au/TiO2, Au/ZrO2 and Au/CeO2 on viability, phagocytic capacity and inflammatory profile (TNF-α and IL-1β secretion) of murine macrophages. The most important result of this study is an anti-inflammatory effect of Au/MOx depending on the MOx nature with particle internalization and no alteration of cell viability and phagocytosis. The effect was dependent on the MOx NPs chemical nature (Au/TiO2 > Au/ZrO2 > Au/CeO2 if we consider the number of cytokines whose concentration was reduced by the NPs), and on the inflammatory mediator considered. The effect of Au/TiO2 NPs was not related to Au NPs size (at least in the case of Au/TiO2 NPs in the range of 3–8 nm). To the best of our knowledge, this is the first demonstration of an anti-inflammatory effect of Au/MOx.https://doi.org/10.1038/s41598-021-02419-4 |
| spellingShingle | Takashi Fujita Maeva Zysman Dan Elgrabli Toru Murayama Masatake Haruta Sophie Lanone Tamao Ishida Jorge Boczkowski Anti-inflammatory effect of gold nanoparticles supported on metal oxides Scientific Reports |
| title | Anti-inflammatory effect of gold nanoparticles supported on metal oxides |
| title_full | Anti-inflammatory effect of gold nanoparticles supported on metal oxides |
| title_fullStr | Anti-inflammatory effect of gold nanoparticles supported on metal oxides |
| title_full_unstemmed | Anti-inflammatory effect of gold nanoparticles supported on metal oxides |
| title_short | Anti-inflammatory effect of gold nanoparticles supported on metal oxides |
| title_sort | anti inflammatory effect of gold nanoparticles supported on metal oxides |
| url | https://doi.org/10.1038/s41598-021-02419-4 |
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