Risk Factors and Prognostic Predictors of Ventilator Associated Pneumonia in a Tertiary Care Hospital
Introduction: It was aimed to evaluate the risk factors for the development of ventilator-associated pneumonia (VAP) and clinical outcomes and prognostic predictors of VAP. Materials and Methods: This retrospective and single-center study included patients aged ≥18 years who were diagnosed with VA...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Bilimsel Tip Yayinevi
2022-03-01
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| Series: | Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi |
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| Online Access: | http://floradergisi.org/managete/fu_folder/2022-01/55-64%20Betul%20Copur.pdf |
| _version_ | 1797910869679538176 |
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| author | Betül ÇOPUR Seniha BAŞARAN Günseli ORHUN Serap ŞİMŞEK YAVUZ Atahan ÇAĞATAY Oral ÖNCÜL Halit ÖZSÜT Haluk ERAKSOY |
| author_facet | Betül ÇOPUR Seniha BAŞARAN Günseli ORHUN Serap ŞİMŞEK YAVUZ Atahan ÇAĞATAY Oral ÖNCÜL Halit ÖZSÜT Haluk ERAKSOY |
| author_sort | Betül ÇOPUR |
| collection | DOAJ |
| description | Introduction: It was aimed to evaluate the risk factors for the development of ventilator-associated pneumonia (VAP) and clinical
outcomes and prognostic predictors of VAP.
Materials and Methods: This retrospective and single-center study included patients aged ≥18 years who were diagnosed with VAP
in the ICU. Patients were divided into two groups with VAP or without VAP. Univariable and multivariable analyses were used to assess
risk factors and prognostic predictors of VAP.
Results: A total of 177 patients were evaluated. Mean length of intensive care unit (ICU) stay and the duration of mechanical ventilation was longer in patients with VAP than in patients without VAP [29 (3-107) vs. 12 (3-70) days, 22 (3-90) vs. 10 (3-45) days; p<
0.001]. Rectal colonization with carbapenem-resistant Klebsiella pneumoniae (CRKp) was found to be higher in the VAP group compared to the non-VAP group (n= 41, 58% vs. n= 25, 24%, p< 0.001). Ventilation period (OR= 1.07; 95% CI 1.02-1.12, p= 0.003),
smoking (OR= 3.89; 95% CI 1.68-8.9, p= 0.001), and rectal colonization with CRKp (OR= 4.93; 95% CI 2.09-11.64, p< 0.001)
were detected as independent risk factors for the development of VAP. Age (OR= 1.15; 95% CI 1.03-1.28, p= 0.01), SOFA score (OR=
1.60; 95% CI 1.05-2.43, p= 0.02) and rectal colonization with CRKp (OR= 15.2; 95% CI 2.33-99.01, p= 0.004) were detected as
independent risk factors for mortality in patients with VAP.
Conclusion: In conclusion, decreasing the patient-related and hospital environment related risk factors, routine screening of rectal colonizations with CRKp, and continuous practicing of the universal infection control measures may significantly decrease the prevalence
of ventilator-associated pneumonia |
| first_indexed | 2024-04-10T11:31:25Z |
| format | Article |
| id | doaj.art-d881f73cbc2545c88577dbc7683b34bb |
| institution | Directory Open Access Journal |
| issn | 1300-932X 1308-5115 |
| language | English |
| last_indexed | 2024-04-10T11:31:25Z |
| publishDate | 2022-03-01 |
| publisher | Bilimsel Tip Yayinevi |
| record_format | Article |
| series | Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi |
| spelling | doaj.art-d881f73cbc2545c88577dbc7683b34bb2023-02-15T16:18:05ZengBilimsel Tip YayineviFlora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi1300-932X1308-51152022-03-01271556410.5578/flora.20229906Risk Factors and Prognostic Predictors of Ventilator Associated Pneumonia in a Tertiary Care HospitalBetül ÇOPUR0https://orcid.org/0000-0001-5534-1388Seniha BAŞARAN1https://orcid.org/0000-0002-3402-2510Günseli ORHUN2https://orcid.org/0000-0003-0173-3604Serap ŞİMŞEK YAVUZ3https://orcid.org/0000-0002-4675-169XAtahan ÇAĞATAY4https://orcid.org/0000-0002-3051-8199Oral ÖNCÜL5https://orcid.org/0000-0002-1681-1866Halit ÖZSÜT6https://orcid.org/0000-0002-5222-9320Haluk ERAKSOY7https://orcid.org/0000-0002-5790-0806Clinic of Infectious Diseases and Clinical Microbiology, İstanbul Haseki Research and Training Hospital, İstanbul, TurkeyDepartment of Infectious Diseases and Clinical Microbiology, İstanbul University Faculty of Medicine, İstanbul, TurkeyDepartment of Anesthesiology and Reanimation, İstanbul University Faculty of Medicine, İstanbul, TurkeyDepartment of Infectious Diseases and Clinical Microbiology, İstanbul University Faculty of Medicine, İstanbul, TurkeyDepartment of Infectious Diseases and Clinical Microbiology, İstanbul University Faculty of Medicine, İstanbul, TurkeyDepartment of Infectious Diseases and Clinical Microbiology, İstanbul University Faculty of Medicine, İstanbul, TurkeyDepartment of Infectious Diseases and Clinical Microbiology, İstanbul University Faculty of Medicine, İstanbul, TurkeyDepartment of Infectious Diseases and Clinical Microbiology, İstanbul University Faculty of Medicine, İstanbul, TurkeyIntroduction: It was aimed to evaluate the risk factors for the development of ventilator-associated pneumonia (VAP) and clinical outcomes and prognostic predictors of VAP. Materials and Methods: This retrospective and single-center study included patients aged ≥18 years who were diagnosed with VAP in the ICU. Patients were divided into two groups with VAP or without VAP. Univariable and multivariable analyses were used to assess risk factors and prognostic predictors of VAP. Results: A total of 177 patients were evaluated. Mean length of intensive care unit (ICU) stay and the duration of mechanical ventilation was longer in patients with VAP than in patients without VAP [29 (3-107) vs. 12 (3-70) days, 22 (3-90) vs. 10 (3-45) days; p< 0.001]. Rectal colonization with carbapenem-resistant Klebsiella pneumoniae (CRKp) was found to be higher in the VAP group compared to the non-VAP group (n= 41, 58% vs. n= 25, 24%, p< 0.001). Ventilation period (OR= 1.07; 95% CI 1.02-1.12, p= 0.003), smoking (OR= 3.89; 95% CI 1.68-8.9, p= 0.001), and rectal colonization with CRKp (OR= 4.93; 95% CI 2.09-11.64, p< 0.001) were detected as independent risk factors for the development of VAP. Age (OR= 1.15; 95% CI 1.03-1.28, p= 0.01), SOFA score (OR= 1.60; 95% CI 1.05-2.43, p= 0.02) and rectal colonization with CRKp (OR= 15.2; 95% CI 2.33-99.01, p= 0.004) were detected as independent risk factors for mortality in patients with VAP. Conclusion: In conclusion, decreasing the patient-related and hospital environment related risk factors, routine screening of rectal colonizations with CRKp, and continuous practicing of the universal infection control measures may significantly decrease the prevalence of ventilator-associated pneumoniahttp://floradergisi.org/managete/fu_folder/2022-01/55-64%20Betul%20Copur.pdfventilator-associated pneumoniacarbapenem resistant klebsiella pneumoniaerectal colonizationmortality |
| spellingShingle | Betül ÇOPUR Seniha BAŞARAN Günseli ORHUN Serap ŞİMŞEK YAVUZ Atahan ÇAĞATAY Oral ÖNCÜL Halit ÖZSÜT Haluk ERAKSOY Risk Factors and Prognostic Predictors of Ventilator Associated Pneumonia in a Tertiary Care Hospital Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi ventilator-associated pneumonia carbapenem resistant klebsiella pneumoniae rectal colonization mortality |
| title | Risk Factors and Prognostic Predictors of Ventilator Associated Pneumonia in a Tertiary Care Hospital |
| title_full | Risk Factors and Prognostic Predictors of Ventilator Associated Pneumonia in a Tertiary Care Hospital |
| title_fullStr | Risk Factors and Prognostic Predictors of Ventilator Associated Pneumonia in a Tertiary Care Hospital |
| title_full_unstemmed | Risk Factors and Prognostic Predictors of Ventilator Associated Pneumonia in a Tertiary Care Hospital |
| title_short | Risk Factors and Prognostic Predictors of Ventilator Associated Pneumonia in a Tertiary Care Hospital |
| title_sort | risk factors and prognostic predictors of ventilator associated pneumonia in a tertiary care hospital |
| topic | ventilator-associated pneumonia carbapenem resistant klebsiella pneumoniae rectal colonization mortality |
| url | http://floradergisi.org/managete/fu_folder/2022-01/55-64%20Betul%20Copur.pdf |
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