Objective assessment of a relative afferent pupillary defect by B-mode ultrasound.
PURPOSE:To evaluate B-mode ultrasound as a novel method for objective and quantitative assessment of a relative afferent pupillary defect (RAPD) in a prospective case-control study. METHODS:Seventeen patients with unilateral optic neuropathy and a clinically detectable RAPD and 17 age and sex matche...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC6110480?pdf=render |
| _version_ | 1819080556462211072 |
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| author | Felix A Schmidt Florian Connolly Matthew B Maas Ulrike Grittner Lutz Harms Alexander Brandt Friedemann Paul Stephan Schreiber Klemens Ruprecht |
| author_facet | Felix A Schmidt Florian Connolly Matthew B Maas Ulrike Grittner Lutz Harms Alexander Brandt Friedemann Paul Stephan Schreiber Klemens Ruprecht |
| author_sort | Felix A Schmidt |
| collection | DOAJ |
| description | PURPOSE:To evaluate B-mode ultrasound as a novel method for objective and quantitative assessment of a relative afferent pupillary defect (RAPD) in a prospective case-control study. METHODS:Seventeen patients with unilateral optic neuropathy and a clinically detectable RAPD and 17 age and sex matched healthy controls were examined with B-mode ultrasound using an Esaote-Mylab25 system according to current guidelines for orbital insonation. The swinging flashlight test was performed during ultrasound assessment with a standardized light stimulus using a penlight. RESULTS:B-mode ultrasound RAPD examination was doable in approximately 5 minutes only and was well tolerated by all participants. Compared to the unaffected contralateral eyes, eyes with RAPD showed lower absolute constriction amplitude of the pupillary diameter (mean [SD] 0.8 [0.4] vs. 2.1 [0.4] mm; p = 0.009) and a longer pupillary constriction time after ipsilateral light stimulus (mean [SD] 1240 [180] vs. 710 [200] ms; p = 0.008). In eyes affected by RAPD, visual acuity correlated with the absolute constriction amplitude (r = 0.75, p = 0.001). CONCLUSIONS:B-mode ultrasound enables fast, easy and objective quantification of a RAPD and can thus be applied in clinical practice to document a RAPD. |
| first_indexed | 2024-12-21T19:46:46Z |
| format | Article |
| id | doaj.art-d8835b48ab40463a90703d125ece0d25 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T19:46:46Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-d8835b48ab40463a90703d125ece0d252022-12-21T18:52:18ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01138e020277410.1371/journal.pone.0202774Objective assessment of a relative afferent pupillary defect by B-mode ultrasound.Felix A SchmidtFlorian ConnollyMatthew B MaasUlrike GrittnerLutz HarmsAlexander BrandtFriedemann PaulStephan SchreiberKlemens RuprechtPURPOSE:To evaluate B-mode ultrasound as a novel method for objective and quantitative assessment of a relative afferent pupillary defect (RAPD) in a prospective case-control study. METHODS:Seventeen patients with unilateral optic neuropathy and a clinically detectable RAPD and 17 age and sex matched healthy controls were examined with B-mode ultrasound using an Esaote-Mylab25 system according to current guidelines for orbital insonation. The swinging flashlight test was performed during ultrasound assessment with a standardized light stimulus using a penlight. RESULTS:B-mode ultrasound RAPD examination was doable in approximately 5 minutes only and was well tolerated by all participants. Compared to the unaffected contralateral eyes, eyes with RAPD showed lower absolute constriction amplitude of the pupillary diameter (mean [SD] 0.8 [0.4] vs. 2.1 [0.4] mm; p = 0.009) and a longer pupillary constriction time after ipsilateral light stimulus (mean [SD] 1240 [180] vs. 710 [200] ms; p = 0.008). In eyes affected by RAPD, visual acuity correlated with the absolute constriction amplitude (r = 0.75, p = 0.001). CONCLUSIONS:B-mode ultrasound enables fast, easy and objective quantification of a RAPD and can thus be applied in clinical practice to document a RAPD.http://europepmc.org/articles/PMC6110480?pdf=render |
| spellingShingle | Felix A Schmidt Florian Connolly Matthew B Maas Ulrike Grittner Lutz Harms Alexander Brandt Friedemann Paul Stephan Schreiber Klemens Ruprecht Objective assessment of a relative afferent pupillary defect by B-mode ultrasound. PLoS ONE |
| title | Objective assessment of a relative afferent pupillary defect by B-mode ultrasound. |
| title_full | Objective assessment of a relative afferent pupillary defect by B-mode ultrasound. |
| title_fullStr | Objective assessment of a relative afferent pupillary defect by B-mode ultrasound. |
| title_full_unstemmed | Objective assessment of a relative afferent pupillary defect by B-mode ultrasound. |
| title_short | Objective assessment of a relative afferent pupillary defect by B-mode ultrasound. |
| title_sort | objective assessment of a relative afferent pupillary defect by b mode ultrasound |
| url | http://europepmc.org/articles/PMC6110480?pdf=render |
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