Identification of cuproptosis-associated IncRNAs signature and establishment of a novel nomogram for prognosis of stomach adenocarcinoma
Purpose: Stomach adenocarcinoma (STAD) is one of the common cancers globally. Cuproptosis is a newly identified cell death pattern. The role of cuproptosis-associated lncRNAs in STAD is unknown.Methods: STAD patient data from TCGA were used to identify prognostic lncRNAs by Cox regression and LASSO....
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2022.982888/full |
| _version_ | 1828177568450215936 |
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| author | Wei Yu Hongqi Huo Zhixin You Rong Lu Tianci Yao Jing Huang |
| author_facet | Wei Yu Hongqi Huo Zhixin You Rong Lu Tianci Yao Jing Huang |
| author_sort | Wei Yu |
| collection | DOAJ |
| description | Purpose: Stomach adenocarcinoma (STAD) is one of the common cancers globally. Cuproptosis is a newly identified cell death pattern. The role of cuproptosis-associated lncRNAs in STAD is unknown.Methods: STAD patient data from TCGA were used to identify prognostic lncRNAs by Cox regression and LASSO. A nomogram was constructed to predict patient survival. The biological profiles were evaluated through GO and KEGG.Results: We identified 298 cuproptosis-related lncRNAs and 13 survival-related lncRNAs. Patients could be categorized into either high risk group or low risk group with 9-lncRNA risk model with significantly different survival time (p < 0.001). ROC curve and nomogram confirmed the 9-lncRNA risk mode had good prediction capability. Patients in the lower risk score had high gene mutation burden. We also found that patients in the two groups might respond differently to immune checkpoint inhibitors and some anti-tumor compounds.Conclusion: The nomogram with 9-lncRNA may help guide treatment of STAD. Future clinical studies are necessary to verify the nomogram. |
| first_indexed | 2024-04-12T05:00:43Z |
| format | Article |
| id | doaj.art-d883e3fb24714cf6803b79c22f2d348d |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-04-12T05:00:43Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-d883e3fb24714cf6803b79c22f2d348d2022-12-22T03:47:01ZengFrontiers Media S.A.Frontiers in Genetics1664-80212022-09-011310.3389/fgene.2022.982888982888Identification of cuproptosis-associated IncRNAs signature and establishment of a novel nomogram for prognosis of stomach adenocarcinomaWei Yu0Hongqi Huo1Zhixin You2Rong Lu3Tianci Yao4Jing Huang5Department of Pharmacy, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, ChinaNuclear Medicine Department, HanDan Central Hospital, Handan, ChinaNuclear Medicine Department, HanDan Central Hospital, Handan, ChinaDepartment of Laboratory Medicine, The First Affiliated Hospital of Xiamen University, Xiamen Key Laboratory of Genetic Testing, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Pharmacy, The First Affiliated Hospital of Xiamen University, Xiamen, ChinaDepartment of Pharmacy, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, ChinaPurpose: Stomach adenocarcinoma (STAD) is one of the common cancers globally. Cuproptosis is a newly identified cell death pattern. The role of cuproptosis-associated lncRNAs in STAD is unknown.Methods: STAD patient data from TCGA were used to identify prognostic lncRNAs by Cox regression and LASSO. A nomogram was constructed to predict patient survival. The biological profiles were evaluated through GO and KEGG.Results: We identified 298 cuproptosis-related lncRNAs and 13 survival-related lncRNAs. Patients could be categorized into either high risk group or low risk group with 9-lncRNA risk model with significantly different survival time (p < 0.001). ROC curve and nomogram confirmed the 9-lncRNA risk mode had good prediction capability. Patients in the lower risk score had high gene mutation burden. We also found that patients in the two groups might respond differently to immune checkpoint inhibitors and some anti-tumor compounds.Conclusion: The nomogram with 9-lncRNA may help guide treatment of STAD. Future clinical studies are necessary to verify the nomogram.https://www.frontiersin.org/articles/10.3389/fgene.2022.982888/fullrisk scoreprognosiscuproptosisimmunetumor |
| spellingShingle | Wei Yu Hongqi Huo Zhixin You Rong Lu Tianci Yao Jing Huang Identification of cuproptosis-associated IncRNAs signature and establishment of a novel nomogram for prognosis of stomach adenocarcinoma Frontiers in Genetics risk score prognosis cuproptosis immune tumor |
| title | Identification of cuproptosis-associated IncRNAs signature and establishment of a novel nomogram for prognosis of stomach adenocarcinoma |
| title_full | Identification of cuproptosis-associated IncRNAs signature and establishment of a novel nomogram for prognosis of stomach adenocarcinoma |
| title_fullStr | Identification of cuproptosis-associated IncRNAs signature and establishment of a novel nomogram for prognosis of stomach adenocarcinoma |
| title_full_unstemmed | Identification of cuproptosis-associated IncRNAs signature and establishment of a novel nomogram for prognosis of stomach adenocarcinoma |
| title_short | Identification of cuproptosis-associated IncRNAs signature and establishment of a novel nomogram for prognosis of stomach adenocarcinoma |
| title_sort | identification of cuproptosis associated incrnas signature and establishment of a novel nomogram for prognosis of stomach adenocarcinoma |
| topic | risk score prognosis cuproptosis immune tumor |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2022.982888/full |
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