In vitro and in vivo evaluation of nanoliposomes loading quercetin and 3-bromopyruvate against glioma
Abstract Background Diffuse astrocytoma (a type of glioma) and its prevalence are matters of concern worldwide. Patients with this type of tumour have a poor prognosis because after surgical treatment, radiotherapy and/or chemotherapy, these tumours eventually regrow or progress. To date, there is n...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2024-01-01
|
| Series: | Future Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43094-023-00575-0 |
| _version_ | 1797355951554035712 |
|---|---|
| author | Marvin Antonio Soriano-Ursúa Angélica Vega-García Vinnitsa Buzoianu-Anguiano Ana Lilia Ocampo-Nestor Joaquín Manjarrez-Marmolejo Iris Angélica Feria-Romero |
| author_facet | Marvin Antonio Soriano-Ursúa Angélica Vega-García Vinnitsa Buzoianu-Anguiano Ana Lilia Ocampo-Nestor Joaquín Manjarrez-Marmolejo Iris Angélica Feria-Romero |
| author_sort | Marvin Antonio Soriano-Ursúa |
| collection | DOAJ |
| description | Abstract Background Diffuse astrocytoma (a type of glioma) and its prevalence are matters of concern worldwide. Patients with this type of tumour have a poor prognosis because after surgical treatment, radiotherapy and/or chemotherapy, these tumours eventually regrow or progress. To date, there is no effective treatment that can cure affected patients. Quercetin and 3-bromopyruvate are chemical compounds that have been proven to have antitumour effects alone or in combination with other compounds. Nevertheless, combination treatments including these agents are not used for treating diffuse astrocytoma. Methods The use of nanoliposomes loaded with quercetin and 3-bromopyruvate as combination therapy was evaluated by treating C6 cells in vitro and in vivo (in Sprague–Dawley rat brain). Results The 0.5 mg/mL quercetin + 0.75 mg/mL 3-bromopyruvate combination treatment decreased the expression of the biomarkers Annexin V and Caspase-3 and inhibited tumour growth; this was consistent with the in vivo results that revealed the administration of this treatment resulted in improved animal survival. Conclusions The observations in the present study support the further exploration of this combination of active agents in the treatment of high-grade diffuse astrocytoma, especially in cases for which wide resection is possible. |
| first_indexed | 2024-03-08T14:18:35Z |
| format | Article |
| id | doaj.art-d885003c7b224ecd84b6e16d8e60033a |
| institution | Directory Open Access Journal |
| issn | 2314-7253 |
| language | English |
| last_indexed | 2024-03-08T14:18:35Z |
| publishDate | 2024-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Future Journal of Pharmaceutical Sciences |
| spelling | doaj.art-d885003c7b224ecd84b6e16d8e60033a2024-01-14T12:14:53ZengSpringerOpenFuture Journal of Pharmaceutical Sciences2314-72532024-01-0110111310.1186/s43094-023-00575-0In vitro and in vivo evaluation of nanoliposomes loading quercetin and 3-bromopyruvate against gliomaMarvin Antonio Soriano-Ursúa0Angélica Vega-García1Vinnitsa Buzoianu-Anguiano2Ana Lilia Ocampo-Nestor3Joaquín Manjarrez-Marmolejo4Iris Angélica Feria-Romero5Academia de Fisiología Humana, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, Col. Casco de Santo TomásUnidad de Investigación Médica en Enfermedades Neurológicas, Hospital de Especialidades Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social. Av. CuauhtémocUnidad de Investigación Médica en Enfermedades Neurológicas, Hospital de Especialidades Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social. Av. CuauhtémocAcademia de Fisiología Humana, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, Col. Casco de Santo TomásLaboratorio de Fisiología de La Formación Reticular, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco SuárezUnidad de Investigación Médica en Enfermedades Neurológicas, Hospital de Especialidades Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social. Av. CuauhtémocAbstract Background Diffuse astrocytoma (a type of glioma) and its prevalence are matters of concern worldwide. Patients with this type of tumour have a poor prognosis because after surgical treatment, radiotherapy and/or chemotherapy, these tumours eventually regrow or progress. To date, there is no effective treatment that can cure affected patients. Quercetin and 3-bromopyruvate are chemical compounds that have been proven to have antitumour effects alone or in combination with other compounds. Nevertheless, combination treatments including these agents are not used for treating diffuse astrocytoma. Methods The use of nanoliposomes loaded with quercetin and 3-bromopyruvate as combination therapy was evaluated by treating C6 cells in vitro and in vivo (in Sprague–Dawley rat brain). Results The 0.5 mg/mL quercetin + 0.75 mg/mL 3-bromopyruvate combination treatment decreased the expression of the biomarkers Annexin V and Caspase-3 and inhibited tumour growth; this was consistent with the in vivo results that revealed the administration of this treatment resulted in improved animal survival. Conclusions The observations in the present study support the further exploration of this combination of active agents in the treatment of high-grade diffuse astrocytoma, especially in cases for which wide resection is possible.https://doi.org/10.1186/s43094-023-00575-0High-grade diffuse gliomaLoaded liposomesApoptosisTumour volume |
| spellingShingle | Marvin Antonio Soriano-Ursúa Angélica Vega-García Vinnitsa Buzoianu-Anguiano Ana Lilia Ocampo-Nestor Joaquín Manjarrez-Marmolejo Iris Angélica Feria-Romero In vitro and in vivo evaluation of nanoliposomes loading quercetin and 3-bromopyruvate against glioma Future Journal of Pharmaceutical Sciences High-grade diffuse glioma Loaded liposomes Apoptosis Tumour volume |
| title | In vitro and in vivo evaluation of nanoliposomes loading quercetin and 3-bromopyruvate against glioma |
| title_full | In vitro and in vivo evaluation of nanoliposomes loading quercetin and 3-bromopyruvate against glioma |
| title_fullStr | In vitro and in vivo evaluation of nanoliposomes loading quercetin and 3-bromopyruvate against glioma |
| title_full_unstemmed | In vitro and in vivo evaluation of nanoliposomes loading quercetin and 3-bromopyruvate against glioma |
| title_short | In vitro and in vivo evaluation of nanoliposomes loading quercetin and 3-bromopyruvate against glioma |
| title_sort | in vitro and in vivo evaluation of nanoliposomes loading quercetin and 3 bromopyruvate against glioma |
| topic | High-grade diffuse glioma Loaded liposomes Apoptosis Tumour volume |
| url | https://doi.org/10.1186/s43094-023-00575-0 |
| work_keys_str_mv | AT marvinantoniosorianoursua invitroandinvivoevaluationofnanoliposomesloadingquercetinand3bromopyruvateagainstglioma AT angelicavegagarcia invitroandinvivoevaluationofnanoliposomesloadingquercetinand3bromopyruvateagainstglioma AT vinnitsabuzoianuanguiano invitroandinvivoevaluationofnanoliposomesloadingquercetinand3bromopyruvateagainstglioma AT analiliaocamponestor invitroandinvivoevaluationofnanoliposomesloadingquercetinand3bromopyruvateagainstglioma AT joaquinmanjarrezmarmolejo invitroandinvivoevaluationofnanoliposomesloadingquercetinand3bromopyruvateagainstglioma AT irisangelicaferiaromero invitroandinvivoevaluationofnanoliposomesloadingquercetinand3bromopyruvateagainstglioma |