RETRACTED ARTICLE: Systematic review and meta-analysis of the epidemiology of vancomycin-resistance Staphylococcus aureus isolates
Abstract Background Vancomycin‑resistant Staphylococcus aureus (VRSA) is a serious public health challenging concern worldwide. Objectives Therefore, the objective of present study of 62 published studies was to evaluate the prevalence of VRSA based on different years, areas, isolate source, antimic...
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| Format: | Article |
| Language: | English |
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BMC
2021-06-01
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| Series: | Antimicrobial Resistance and Infection Control |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13756-021-00967-y |
| _version_ | 1797636713500114944 |
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| author | Qianxing Wu Niloofar Sabokroo Yujie Wang Marzieh Hashemian Somayeh Karamollahi Ebrahim Kouhsari |
| author_facet | Qianxing Wu Niloofar Sabokroo Yujie Wang Marzieh Hashemian Somayeh Karamollahi Ebrahim Kouhsari |
| author_sort | Qianxing Wu |
| collection | DOAJ |
| description | Abstract Background Vancomycin‑resistant Staphylococcus aureus (VRSA) is a serious public health challenging concern worldwide. Objectives Therefore, the objective of present study of 62 published studies was to evaluate the prevalence of VRSA based on different years, areas, isolate source, antimicrobial susceptibility testing, and the genetic determinants. Methods We searched the relevant articles that focused on the prevalence rates of VRSA in PubMed, Scopus, Embase, and Web of Science from 2000 to 2019. Statistical analyses were conducted using STATA software (version 14.0). Results The prevalence of VRSA was 2% before 2006, 5% in 2006–2014, and 7% in 2015–2020 that showed a 3.5-fold increase in the frequency of VRSA between before 2006 and 2020 years. The prevalence of VRSA was 5% in Asia, 1% in Europe, 4% in America, 3% in South America, and 16% in Africa. The frequencies of VRSA isolated from clinical, non-clinical, and mixed samples were 6%, 7%, and 14%, respectively. The prevalence of VRSA was 12% using disk diffusion agar method, 7% using MIC-base methods, and 4% using mixed-methods. The prevalence of vanA, vanB, and vanC1 positive were 71%, 26%, and 4% among VRSA strains. The most prevalent genotype was staphylococcal cassette chromosomemec (SCCmec) II, which accounted for 57% of VRSA. The most prevalent staphylococcal protein A (spa) types were t002, t030, and t037. Conclusion The prevalence of VRSA has been increasing in recent years particularly in Africa/Asia than Europe/America. The most prevalent of genetic determinants associated with VRSA were vanA and SCCmec II. This study clarifies that the rigorous monitoring of definite antibiotic policy, regular surveillance/control of nosocomial-associated infections and intensive surveillance of vancomycin-resistance are required for preventing emergence and further spreading of VRSA. |
| first_indexed | 2024-03-11T12:38:03Z |
| format | Article |
| id | doaj.art-d88553042e044186bf9685a935cf992a |
| institution | Directory Open Access Journal |
| issn | 2047-2994 |
| language | English |
| last_indexed | 2024-03-11T12:38:03Z |
| publishDate | 2021-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Antimicrobial Resistance and Infection Control |
| spelling | doaj.art-d88553042e044186bf9685a935cf992a2023-11-05T12:29:53ZengBMCAntimicrobial Resistance and Infection Control2047-29942021-06-0110111310.1186/s13756-021-00967-yRETRACTED ARTICLE: Systematic review and meta-analysis of the epidemiology of vancomycin-resistance Staphylococcus aureus isolatesQianxing Wu0Niloofar Sabokroo1Yujie Wang2Marzieh Hashemian3Somayeh Karamollahi4Ebrahim Kouhsari5The Medical Lab of Hainan Cancer HospitalDepartment of Microbiology, School of Medicine, Shahid Sadoughi University of Medical SciencesSchool of International Pharmaceutical Business, China Pharmaceutical UniversityClinical Microbiology Research Center, Ilam University of Medical SciencesClinical Microbiology Research Center, Ilam University of Medical SciencesLaboratory Sciences Research Center, Golestan University of Medical SciencesAbstract Background Vancomycin‑resistant Staphylococcus aureus (VRSA) is a serious public health challenging concern worldwide. Objectives Therefore, the objective of present study of 62 published studies was to evaluate the prevalence of VRSA based on different years, areas, isolate source, antimicrobial susceptibility testing, and the genetic determinants. Methods We searched the relevant articles that focused on the prevalence rates of VRSA in PubMed, Scopus, Embase, and Web of Science from 2000 to 2019. Statistical analyses were conducted using STATA software (version 14.0). Results The prevalence of VRSA was 2% before 2006, 5% in 2006–2014, and 7% in 2015–2020 that showed a 3.5-fold increase in the frequency of VRSA between before 2006 and 2020 years. The prevalence of VRSA was 5% in Asia, 1% in Europe, 4% in America, 3% in South America, and 16% in Africa. The frequencies of VRSA isolated from clinical, non-clinical, and mixed samples were 6%, 7%, and 14%, respectively. The prevalence of VRSA was 12% using disk diffusion agar method, 7% using MIC-base methods, and 4% using mixed-methods. The prevalence of vanA, vanB, and vanC1 positive were 71%, 26%, and 4% among VRSA strains. The most prevalent genotype was staphylococcal cassette chromosomemec (SCCmec) II, which accounted for 57% of VRSA. The most prevalent staphylococcal protein A (spa) types were t002, t030, and t037. Conclusion The prevalence of VRSA has been increasing in recent years particularly in Africa/Asia than Europe/America. The most prevalent of genetic determinants associated with VRSA were vanA and SCCmec II. This study clarifies that the rigorous monitoring of definite antibiotic policy, regular surveillance/control of nosocomial-associated infections and intensive surveillance of vancomycin-resistance are required for preventing emergence and further spreading of VRSA.https://doi.org/10.1186/s13756-021-00967-yAntimicrobial resistanceVancomycin‑resistant Staphylococcus aureusSystematic review and meta-analysis |
| spellingShingle | Qianxing Wu Niloofar Sabokroo Yujie Wang Marzieh Hashemian Somayeh Karamollahi Ebrahim Kouhsari RETRACTED ARTICLE: Systematic review and meta-analysis of the epidemiology of vancomycin-resistance Staphylococcus aureus isolates Antimicrobial Resistance and Infection Control Antimicrobial resistance Vancomycin‑resistant Staphylococcus aureus Systematic review and meta-analysis |
| title | RETRACTED ARTICLE: Systematic review and meta-analysis of the epidemiology of vancomycin-resistance Staphylococcus aureus isolates |
| title_full | RETRACTED ARTICLE: Systematic review and meta-analysis of the epidemiology of vancomycin-resistance Staphylococcus aureus isolates |
| title_fullStr | RETRACTED ARTICLE: Systematic review and meta-analysis of the epidemiology of vancomycin-resistance Staphylococcus aureus isolates |
| title_full_unstemmed | RETRACTED ARTICLE: Systematic review and meta-analysis of the epidemiology of vancomycin-resistance Staphylococcus aureus isolates |
| title_short | RETRACTED ARTICLE: Systematic review and meta-analysis of the epidemiology of vancomycin-resistance Staphylococcus aureus isolates |
| title_sort | retracted article systematic review and meta analysis of the epidemiology of vancomycin resistance staphylococcus aureus isolates |
| topic | Antimicrobial resistance Vancomycin‑resistant Staphylococcus aureus Systematic review and meta-analysis |
| url | https://doi.org/10.1186/s13756-021-00967-y |
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